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1I7M

HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COMPLEXED WITH 4-AMIDINOINDAN-1-ONE-2'-AMIDINOHYDRAZONE

Functional Information from GO Data
ChainGOidnamespacecontents
A0004014molecular_functionadenosylmethionine decarboxylase activity
A0006597biological_processspermine biosynthetic process
A0008295biological_processspermidine biosynthetic process
B0004014molecular_functionadenosylmethionine decarboxylase activity
B0008295biological_processspermidine biosynthetic process
C0004014molecular_functionadenosylmethionine decarboxylase activity
C0006597biological_processspermine biosynthetic process
C0008295biological_processspermidine biosynthetic process
D0004014molecular_functionadenosylmethionine decarboxylase activity
D0008295biological_processspermidine biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PUT B 350
ChainResidue
APHE111
AASP174
ATHR176
ATYR318
AHOH1403
BLEU13
BGLU15
BHOH1438
BHOH1445

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PUT D 1350
ChainResidue
CPHE1111
CASP1174
CTHR1176
CPHE1285
CTYR1318
CHOH1401
DLEU1013
DGLU1015
DHOH1419
DHOH1447

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE CG A 375
ChainResidue
APYR68
APHE223
ACYS226
ASER229
AHIS243
AILE244
AGLU247
BPHE7
BLEU65
BSER66
BGLU67

site_idAC4
Number of Residues11
DetailsBINDING SITE FOR RESIDUE CG D 1375
ChainResidue
CPYR1068
CPHE1223
CCYS1226
CSER1229
CHIS1243
CILE1244
CTHR1245
CGLU1247
DLEU1065
DSER1066
DGLU1067

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Schiff-base intermediate with substrate; via pyruvic acid => ECO:0000269|PubMed:11583147
ChainResidueDetails
APYR68
CPYR1068
DGLU1008
DGLU1011

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton donor; for catalytic activity => ECO:0000269|PubMed:10029540, ECO:0000269|PubMed:11583147
ChainResidueDetails
ACYS82
CCYS1082
DPHE1007
DGLU1067

site_idSWS_FT_FI3
Number of Residues4
DetailsACT_SITE: Proton acceptor; for processing activity => ECO:0000269|PubMed:11583147
ChainResidueDetails
ASER229
AHIS243
CSER1229
CHIS1243

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11583147
ChainResidueDetails
APHE223
AGLU247
CPHE1223
CGLU1247

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Pyruvic acid (Ser); by autocatalysis => ECO:0000269|PubMed:2460457, ECO:0000269|PubMed:2687270
ChainResidueDetails
APYR68
CPYR1068

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER298
CSER1298

Catalytic Information from CSA
site_idMCSA1
Number of Residues4
DetailsM-CSA 575
ChainResidueDetails
APYR68covalently attached, electron shuttle
ACYS82proton shuttle (general acid/base)
ASER229
AHIS243

site_idMCSA2
Number of Residues4
DetailsM-CSA 575
ChainResidueDetails
CPYR1068covalently attached, electron shuttle
CCYS1082proton shuttle (general acid/base)
CSER1229
CHIS1243

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PDB entries from 2024-03-27

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