1I7M
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COMPLEXED WITH 4-AMIDINOINDAN-1-ONE-2'-AMIDINOHYDRAZONE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| A | 0006597 | biological_process | spermine biosynthetic process |
| A | 0008295 | biological_process | spermidine biosynthetic process |
| B | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| B | 0008295 | biological_process | spermidine biosynthetic process |
| C | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| C | 0006597 | biological_process | spermine biosynthetic process |
| C | 0008295 | biological_process | spermidine biosynthetic process |
| D | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| D | 0008295 | biological_process | spermidine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PUT B 350 |
| Chain | Residue |
| A | PHE111 |
| A | ASP174 |
| A | THR176 |
| A | TYR318 |
| A | HOH1403 |
| B | LEU13 |
| B | GLU15 |
| B | HOH1438 |
| B | HOH1445 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PUT D 1350 |
| Chain | Residue |
| C | PHE1111 |
| C | ASP1174 |
| C | THR1176 |
| C | PHE1285 |
| C | TYR1318 |
| C | HOH1401 |
| D | LEU1013 |
| D | GLU1015 |
| D | HOH1419 |
| D | HOH1447 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CG A 375 |
| Chain | Residue |
| A | PYR68 |
| A | PHE223 |
| A | CYS226 |
| A | SER229 |
| A | HIS243 |
| A | ILE244 |
| A | GLU247 |
| B | PHE7 |
| B | LEU65 |
| B | SER66 |
| B | GLU67 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CG D 1375 |
| Chain | Residue |
| C | PYR1068 |
| C | PHE1223 |
| C | CYS1226 |
| C | SER1229 |
| C | HIS1243 |
| C | ILE1244 |
| C | THR1245 |
| C | GLU1247 |
| D | LEU1065 |
| D | SER1066 |
| D | GLU1067 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"1917972","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor; for catalytic activity","evidences":[{"source":"PubMed","id":"10029540","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor; for processing activity","evidences":[{"source":"PubMed","id":"11583147","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1jen |
| Chain | Residue | Details |
| A | HIS243 | |
| A | SER229 | |
| A | CYS82 | |
| B | GLU11 | |
| B | GLU67 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1jen |
| Chain | Residue | Details |
| C | SER1229 | |
| C | HIS1243 | |
| C | CYS1082 | |
| D | GLU1011 | |
| D | GLU1067 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 575 |
| Chain | Residue | Details |
| B | PRO23 | proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 575 |
| Chain | Residue | Details |
| D | PRO1023 | proton shuttle (general acid/base) |
