1I7M
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COMPLEXED WITH 4-AMIDINOINDAN-1-ONE-2'-AMIDINOHYDRAZONE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
A | 0006597 | biological_process | spermine biosynthetic process |
A | 0008295 | biological_process | spermidine biosynthetic process |
B | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
B | 0008295 | biological_process | spermidine biosynthetic process |
C | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
C | 0006597 | biological_process | spermine biosynthetic process |
C | 0008295 | biological_process | spermidine biosynthetic process |
D | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
D | 0008295 | biological_process | spermidine biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PUT B 350 |
Chain | Residue |
A | PHE111 |
A | ASP174 |
A | THR176 |
A | TYR318 |
A | HOH1403 |
B | LEU13 |
B | GLU15 |
B | HOH1438 |
B | HOH1445 |
site_id | AC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PUT D 1350 |
Chain | Residue |
C | PHE1111 |
C | ASP1174 |
C | THR1176 |
C | PHE1285 |
C | TYR1318 |
C | HOH1401 |
D | LEU1013 |
D | GLU1015 |
D | HOH1419 |
D | HOH1447 |
site_id | AC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE CG A 375 |
Chain | Residue |
A | PYR68 |
A | PHE223 |
A | CYS226 |
A | SER229 |
A | HIS243 |
A | ILE244 |
A | GLU247 |
B | PHE7 |
B | LEU65 |
B | SER66 |
B | GLU67 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE CG D 1375 |
Chain | Residue |
C | PYR1068 |
C | PHE1223 |
C | CYS1226 |
C | SER1229 |
C | HIS1243 |
C | ILE1244 |
C | THR1245 |
C | GLU1247 |
D | LEU1065 |
D | SER1066 |
D | GLU1067 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Schiff-base intermediate with substrate; via pyruvic acid => ECO:0000269|PubMed:11583147 |
Chain | Residue | Details |
A | PYR68 | |
C | PYR1068 | |
D | GLU1008 | |
D | GLU1011 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor; for catalytic activity => ECO:0000269|PubMed:10029540, ECO:0000269|PubMed:11583147 |
Chain | Residue | Details |
A | CYS82 | |
C | CYS1082 | |
D | PHE1007 | |
D | GLU1067 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor; for processing activity => ECO:0000269|PubMed:11583147 |
Chain | Residue | Details |
A | SER229 | |
A | HIS243 | |
C | SER1229 | |
C | HIS1243 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11583147 |
Chain | Residue | Details |
A | PHE223 | |
A | GLU247 | |
C | PHE1223 | |
C | GLU1247 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Pyruvic acid (Ser); by autocatalysis => ECO:0000269|PubMed:2460457, ECO:0000269|PubMed:2687270 |
Chain | Residue | Details |
A | PYR68 | |
C | PYR1068 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
A | SER298 | |
C | SER1298 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 575 |
Chain | Residue | Details |
A | PYR68 | covalently attached, electron shuttle |
A | CYS82 | proton shuttle (general acid/base) |
A | SER229 | |
A | HIS243 |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 575 |
Chain | Residue | Details |
C | PYR1068 | covalently attached, electron shuttle |
C | CYS1082 | proton shuttle (general acid/base) |
C | SER1229 | |
C | HIS1243 |