1I6L

1.7 HIGH RESOLUTION EXPERIMENTAL PHASES FOR TRYPTOPHANYL-TRNA SYNTHETASE COMPLEXED WITH TRYPTOPHANYL-5'AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004830	molecular_function	tryptophan-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006436	biological_process	tryptophanyl-tRNA aminoacylation
A	0016874	molecular_function	ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 360

Chain	Residue
A	TYR98
A	ARG160
A	LYS163
A	ARG164
A	HOH559
A	HOH625
A	HOH626

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 361

Chain	Residue
A	LYS269
A	THR222
A	TYR265

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 362

Chain	Residue
A	ARG55
A	GLN320
A	GOL373
A	HOH637

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 363

Chain	Residue
A	GLY264
A	TYR265
A	GLY266
A	HOH537

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 364

Chain	Residue
A	ARG182
A	MSE184
A	THR190
A	LYS232

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 365

Chain	Residue
A	LYS178
A	GLY180
A	ALA181
A	ARG182
A	TYR230
A	ASN243
A	HOH513

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 366

Chain	Residue
A	ARG60
A	TYR287
A	HOH549

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NH4 A 400

Chain	Residue
A	GLN30
A	TYR33
A	GLN74
A	HOH584
A	HOH588

---

site_id	AC9
Number of Residues	28
Details	BINDING SITE FOR RESIDUE TYM A 350

Chain	Residue
A	PHE5
A	SER6
A	GLY7
A	ILE8
A	GLN9
A	GLY17
A	ASN18
A	GLY21
A	ALA22
A	VAL40
A	HIS43
A	TYR125
A	MSE129
A	ASP132
A	ILE133
A	VAL143
A	GLY144
A	ASP146
A	GLN147
A	GLY180
A	ALA181
A	ARG182
A	ILE183
A	LYS192
A	MSE193
A	LYS195
A	HOH402
A	HOH574

---

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 370

Chain	Residue
A	ASN34
A	CYS35
A	TYR36
A	THR73
A	GLN74
A	ALA75
A	THR76
A	LYS215
A	LYS306
A	HOH477
A	HOH588

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 371

Chain	Residue
A	SER11
A	GLY12
A	ILE14
A	ASN57
A	ARG60
A	THR205
A	HOH434
A	HOH639
A	HOH674

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 372

Chain	Residue
A	LYS211
A	LYS215
A	LYS306
A	ARG309
A	GOL375
A	HOH485

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 373

Chain	Residue
A	HIS52
A	ARG55
A	GLN56
A	ARG59
A	SO4362
A	HOH461
A	HOH551

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 374

Chain	Residue
A	SER194
A	LYS195
A	SER196
A	LYS192

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 375

Chain	Residue
A	GLU214
A	LYS215
A	LYS218
A	GOL372
A	HOH521
A	HOH576

---

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	10
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..SGvITIGNY

Chain	Residue	Details
A	PRO10-TYR19

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00140, ECO:0000269|PubMed:26555258, ECO:0007744|PDB:5DK4

Chain	Residue	Details
A	GLN9
A	GLY17
A	ASP132
A	GLY144
A	ILE183
A	LYS192

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1d2r

Chain	Residue	Details
A	LYS195

---

site_id	MCSA1
Number of Residues	3
Details	M-CSA 481

Chain	Residue	Details
A	LEU123	electrostatic stabiliser
A	THR212	electrostatic stabiliser
A	SER219	electrostatic stabiliser

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