Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004830 | molecular_function | tryptophan-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006436 | biological_process | tryptophanyl-tRNA aminoacylation |
| A | 0016874 | molecular_function | ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 360 |
| Chain | Residue |
| A | TYR98 |
| A | ARG160 |
| A | LYS163 |
| A | ARG164 |
| A | HOH559 |
| A | HOH625 |
| A | HOH626 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 361 |
| Chain | Residue |
| A | LYS269 |
| A | THR222 |
| A | TYR265 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 362 |
| Chain | Residue |
| A | ARG55 |
| A | GLN320 |
| A | GOL373 |
| A | HOH637 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 363 |
| Chain | Residue |
| A | GLY264 |
| A | TYR265 |
| A | GLY266 |
| A | HOH537 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 364 |
| Chain | Residue |
| A | ARG182 |
| A | MSE184 |
| A | THR190 |
| A | LYS232 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 365 |
| Chain | Residue |
| A | LYS178 |
| A | GLY180 |
| A | ALA181 |
| A | ARG182 |
| A | TYR230 |
| A | ASN243 |
| A | HOH513 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 366 |
| Chain | Residue |
| A | ARG60 |
| A | TYR287 |
| A | HOH549 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NH4 A 400 |
| Chain | Residue |
| A | GLN30 |
| A | TYR33 |
| A | GLN74 |
| A | HOH584 |
| A | HOH588 |
| site_id | AC9 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE TYM A 350 |
| Chain | Residue |
| A | PHE5 |
| A | SER6 |
| A | GLY7 |
| A | ILE8 |
| A | GLN9 |
| A | GLY17 |
| A | ASN18 |
| A | GLY21 |
| A | ALA22 |
| A | VAL40 |
| A | HIS43 |
| A | TYR125 |
| A | MSE129 |
| A | ASP132 |
| A | ILE133 |
| A | VAL143 |
| A | GLY144 |
| A | ASP146 |
| A | GLN147 |
| A | GLY180 |
| A | ALA181 |
| A | ARG182 |
| A | ILE183 |
| A | LYS192 |
| A | MSE193 |
| A | LYS195 |
| A | HOH402 |
| A | HOH574 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 370 |
| Chain | Residue |
| A | ASN34 |
| A | CYS35 |
| A | TYR36 |
| A | THR73 |
| A | GLN74 |
| A | ALA75 |
| A | THR76 |
| A | LYS215 |
| A | LYS306 |
| A | HOH477 |
| A | HOH588 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 371 |
| Chain | Residue |
| A | SER11 |
| A | GLY12 |
| A | ILE14 |
| A | ASN57 |
| A | ARG60 |
| A | THR205 |
| A | HOH434 |
| A | HOH639 |
| A | HOH674 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 372 |
| Chain | Residue |
| A | LYS211 |
| A | LYS215 |
| A | LYS306 |
| A | ARG309 |
| A | GOL375 |
| A | HOH485 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 373 |
| Chain | Residue |
| A | HIS52 |
| A | ARG55 |
| A | GLN56 |
| A | ARG59 |
| A | SO4362 |
| A | HOH461 |
| A | HOH551 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 374 |
| Chain | Residue |
| A | SER194 |
| A | LYS195 |
| A | SER196 |
| A | LYS192 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 375 |
| Chain | Residue |
| A | GLU214 |
| A | LYS215 |
| A | LYS218 |
| A | GOL372 |
| A | HOH521 |
| A | HOH576 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 10 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..SGvITIGNY |
| Chain | Residue | Details |
| A | PRO10-TYR19 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"'HIGH' region","evidences":[{"source":"HAMAP-Rule","id":"MF_00140","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00140","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26555258","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DK4","evidenceCode":"ECO:0007744"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1d2r |
| Chain | Residue | Details |
| A | LYS195 | |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 481 |
| Chain | Residue | Details |
| A | LEU123 | electrostatic stabiliser |
| A | THR212 | electrostatic stabiliser |
| A | SER219 | electrostatic stabiliser |
