Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1I41

CYSTATHIONINE GAMMA-SYNTHASE IN COMPLEX WITH THE INHIBITOR APPA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003962	molecular_function	cystathionine gamma-synthase activity
A	0009086	biological_process	methionine biosynthetic process
A	0019346	biological_process	transsulfuration
A	0030170	molecular_function	pyridoxal phosphate binding
B	0003962	molecular_function	cystathionine gamma-synthase activity
B	0009086	biological_process	methionine biosynthetic process
B	0019346	biological_process	transsulfuration
B	0030170	molecular_function	pyridoxal phosphate binding
C	0003962	molecular_function	cystathionine gamma-synthase activity
C	0009086	biological_process	methionine biosynthetic process
C	0019346	biological_process	transsulfuration
C	0030170	molecular_function	pyridoxal phosphate binding
D	0003962	molecular_function	cystathionine gamma-synthase activity
D	0009086	biological_process	methionine biosynthetic process
D	0019346	biological_process	transsulfuration
D	0030170	molecular_function	pyridoxal phosphate binding
E	0003962	molecular_function	cystathionine gamma-synthase activity
E	0009086	biological_process	methionine biosynthetic process
E	0019346	biological_process	transsulfuration
E	0030170	molecular_function	pyridoxal phosphate binding
F	0003962	molecular_function	cystathionine gamma-synthase activity
F	0009086	biological_process	methionine biosynthetic process
F	0019346	biological_process	transsulfuration
F	0030170	molecular_function	pyridoxal phosphate binding
G	0003962	molecular_function	cystathionine gamma-synthase activity
G	0009086	biological_process	methionine biosynthetic process
G	0019346	biological_process	transsulfuration
G	0030170	molecular_function	pyridoxal phosphate binding
H	0003962	molecular_function	cystathionine gamma-synthase activity
H	0009086	biological_process	methionine biosynthetic process
H	0019346	biological_process	transsulfuration
H	0030170	molecular_function	pyridoxal phosphate binding
I	0003962	molecular_function	cystathionine gamma-synthase activity
I	0009086	biological_process	methionine biosynthetic process
I	0019346	biological_process	transsulfuration
I	0030170	molecular_function	pyridoxal phosphate binding
J	0003962	molecular_function	cystathionine gamma-synthase activity
J	0009086	biological_process	methionine biosynthetic process
J	0019346	biological_process	transsulfuration
J	0030170	molecular_function	pyridoxal phosphate binding
K	0003962	molecular_function	cystathionine gamma-synthase activity
K	0009086	biological_process	methionine biosynthetic process
K	0019346	biological_process	transsulfuration
K	0030170	molecular_function	pyridoxal phosphate binding
L	0003962	molecular_function	cystathionine gamma-synthase activity
L	0009086	biological_process	methionine biosynthetic process
L	0019346	biological_process	transsulfuration
L	0030170	molecular_function	pyridoxal phosphate binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEN A 500

Chain	Residue
A	SER137
A	THR260
A	LYS261
A	PRO387
A	SER388
A	SER403
A	ARG423
C	GLU107
C	TYR108
C	ARG110
C	TYR111
A	GLY138
A	MET139
A	TYR163
A	GLU207
A	ASN211
A	ASP236
A	THR238
A	SER258

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEN B 501

Chain	Residue
B	SER137
B	GLY138
B	MET139
B	TYR163
B	GLU207
B	ASN211
B	ASP236
B	THR238
B	SER258
B	THR260
B	LYS261
B	PRO387
B	SER388
B	PHE389
B	SER403
B	ARG423
D	GLU107
D	TYR108
D	ARG110
D	TYR111

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEN C 502

Chain	Residue
A	GLU107
A	TYR108
A	ARG110
A	TYR111
C	SER137
C	GLY138
C	MET139
C	TYR163
C	GLU207
C	ASP236
C	SER258
C	THR260
C	LYS261
C	SER388
C	PHE389
C	SER403
C	ARG423

site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEN D 503

Chain	Residue
B	GLU107
B	TYR108
B	ARG110
B	TYR111
D	SER137
D	GLY138
D	MET139
D	TYR163
D	GLU207
D	ASN211
D	ASP236
D	THR238
D	SER258
D	THR260
D	LYS261
D	PRO387
D	SER388
D	PHE389
D	SER403
D	ARG423

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEN E 504

Chain	Residue
E	SER137
E	GLY138
E	MET139
E	TYR163
E	LYS165
E	GLU207
E	ASP236
E	THR238
E	SER258
E	THR260
E	LYS261
E	SER388
E	PHE389
E	SER403
E	ARG423
G	GLU107
G	TYR108
G	ARG110
G	TYR111

site_id	AC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEN F 505

Chain	Residue
F	GLU207
F	ASN211
F	ASP236
F	SER258
F	THR260
F	LYS261
F	SER388
F	PHE389
F	SER403
F	ARG423
H	GLU107
H	TYR108
H	ARG110
H	TYR111
F	SER137
F	GLY138
F	MET139
F	TYR163

site_id	AC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEN G 506

Chain	Residue
E	GLU107
E	TYR108
E	ARG110
E	TYR111
G	SER137
G	GLY138
G	MET139
G	TYR163
G	GLU207
G	ASN211
G	ASP236
G	SER258
G	THR260
G	LYS261
G	PRO387
G	SER388
G	PHE389
G	SER403
G	ARG423

site_id	AC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEN H 507

Chain	Residue
F	GLU107
F	TYR108
F	ARG110
F	TYR111
H	SER137
H	GLY138
H	MET139
H	TYR163
H	GLU207
H	ASN211
H	ASP236
H	THR238
H	SER258
H	THR260
H	LYS261
H	PHE389
H	SER403
H	ARG423

site_id	AC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEN I 508

Chain	Residue
I	SER137
I	GLY138
I	MET139
I	TYR163
I	GLU207
I	ASN211
I	ASP236
I	THR238
I	SER258
I	THR260
I	LYS261
I	PRO387
I	SER388
I	PHE389
I	SER403
I	ARG423
K	GLU107
K	TYR108
K	ARG110
K	TYR111

site_id	BC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE HEN J 509

Chain	Residue
J	SER137
J	GLY138
J	MET139
J	TYR163
J	GLU207
J	ASP236
J	THR238
J	SER258
J	THR260
J	LYS261
J	SER388
J	PHE389
J	SER403
J	ARG423
L	GLU107
L	TYR108
L	ARG110
L	TYR111

site_id	BC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEN K 510

Chain	Residue
I	GLU107
I	TYR108
I	ARG110
I	TYR111
K	SER137
K	GLY138
K	MET139
K	TYR163
K	LYS165
K	ASP236
K	SER258
K	THR260
K	LYS261
K	SER388
K	PHE389
K	SER403
K	ARG423

site_id	BC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEN L 511

Chain	Residue
J	GLU107
J	TYR108
J	ARG110
J	TYR111
L	SER137
L	GLY138
L	MET139
L	TYR163
L	GLU207
L	ASN211
L	ASP236
L	THR238
L	SER258
L	THR260
L	LYS261
L	SER388
L	PHE389
L	SER403
L	ARG423

Functional Information from PROSITE/UniProt

site_id	PS00868
Number of Residues	15
Details	CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DLvlhSATKFLgGHN

Chain	Residue	Details
A	ASP253-ASN267

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10438597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11518531","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1I43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1I48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QGN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10438597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11518531","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1I48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QGN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"10438597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11518531","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1I43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1I48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QGN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
A	ASP236
A	LYS261
A	TYR163

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
J	ASP236
J	LYS261
J	TYR163

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
K	ASP236
K	LYS261
K	TYR163

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
L	ASP236
L	LYS261
L	TYR163

site_id	CSA13
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
A	ARG110
C	ASP236
C	TYR163

site_id	CSA14
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
D	ASP236
D	TYR163
B	ARG110

site_id	CSA15
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
A	ASP236
A	TYR163
C	ARG110

site_id	CSA16
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
D	ARG110
B	ASP236
B	TYR163

site_id	CSA17
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
G	ASP236
G	TYR163
E	ARG110

site_id	CSA18
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
F	ARG110
H	ASP236
H	TYR163

site_id	CSA19
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
G	ARG110
E	ASP236
E	TYR163

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
B	ASP236
B	LYS261
B	TYR163

site_id	CSA20
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
H	ARG110
F	ASP236
F	TYR163

site_id	CSA21
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
I	ARG110
K	ASP236
K	TYR163

site_id	CSA22
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
J	ARG110
L	ASP236
L	TYR163

site_id	CSA23
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
K	ARG110
I	ASP236
I	TYR163

site_id	CSA24
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
J	ASP236
J	TYR163
L	ARG110

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
C	ASP236
C	LYS261
C	TYR163

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
D	ASP236
D	LYS261
D	TYR163

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
E	ASP236
E	LYS261
E	TYR163

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
F	ASP236
F	LYS261
F	TYR163

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
G	ASP236
G	LYS261
G	TYR163

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
H	ASP236
H	LYS261
H	TYR163

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1b8g

Chain	Residue	Details
I	ASP236
I	LYS261
I	TYR163

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)