1I1R

CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005125	molecular_function	cytokine activity
B	0005138	molecular_function	interleukin-6 receptor binding
B	0005576	cellular_component	extracellular region
B	0006955	biological_process	immune response
B	0030154	biological_process	cell differentiation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	94
Details	Domain: {"description":"Ig-like C2-type"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	91
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	100
Details	Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V2A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V2A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36930708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39532904","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D85","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V29","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8V2A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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