1I1I

NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0004222	molecular_function	metalloendopeptidase activity
P	0005758	cellular_component	mitochondrial intermembrane space
P	0005829	cellular_component	cytosol
P	0006508	biological_process	proteolysis
P	0008233	molecular_function	peptidase activity
P	0008237	molecular_function	metallopeptidase activity
P	0030163	biological_process	protein catabolic process
P	0043171	biological_process	peptide catabolic process
P	0070012	molecular_function	oligopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN P 701

Chain	Residue
P	HIS474
P	HIS478
P	GLU503
P	SER506
P	HOH703

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 702

Chain	Residue
P	HIS125
P	HIS160
P	GLU164
P	HOH817

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TYFHEFGHVM

Chain	Residue	Details
P	THR471-MET480

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9BYT8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 11248043

Chain	Residue	Details
P	TYR613
P	GLU503

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site_id	MCSA1
Number of Residues	5
Details	M-CSA 638

Chain

Residue

Details

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