1I1I

NEUROLYSIN (ENDOPEPTIDASE 24.16) CRYSTAL STRUCTURE

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0004222	molecular_function	metalloendopeptidase activity
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005758	cellular_component	mitochondrial intermembrane space
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0006111	biological_process	regulation of gluconeogenesis
P	0006508	biological_process	proteolysis
P	0006518	biological_process	peptide metabolic process
P	0008233	molecular_function	peptidase activity
P	0008237	molecular_function	metallopeptidase activity
P	0030163	biological_process	protein catabolic process
P	0042277	molecular_function	peptide binding
P	0043171	biological_process	peptide catabolic process
P	0046872	molecular_function	metal ion binding
P	0070012	molecular_function	oligopeptidase activity
P	1902809	biological_process	regulation of skeletal muscle fiber differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN P 701

Chain	Residue
P	HIS474
P	HIS478
P	GLU503
P	SER506
P	HOH703

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 702

Chain	Residue
P	HIS125
P	HIS160
P	GLU164
P	HOH817

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TYFHEFGHVM

Chain	Residue	Details
P	THR471-MET480

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
P	GLU475

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
P	HIS474
P	HIS478
P	HIS481

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9BYT8

Chain	Residue	Details
P	LYS641

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 11248043

Chain	Residue	Details
P	TYR613
P	GLU503

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site_id	MCSA1
Number of Residues	5
Details	M-CSA 638

Chain	Residue	Details
P	HIS474
P	GLU475
P	HIS478
P	GLU503	proton shuttle (general acid/base)
P	TYR613	electrostatic stabiliser

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