1HW1
THE FADR-DNA COMPLEX: TRANSCRIPTIONAL CONTROL OF FATTY ACID METABOLISM IN ESCHERICHIA COLI
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000062 | molecular_function | fatty-acyl-CoA binding |
| A | 0000987 | molecular_function | cis-regulatory region sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0019217 | biological_process | regulation of fatty acid metabolic process |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045723 | biological_process | positive regulation of fatty acid biosynthetic process |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0000062 | molecular_function | fatty-acyl-CoA binding |
| B | 0000987 | molecular_function | cis-regulatory region sequence-specific DNA binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0019217 | biological_process | regulation of fatty acid metabolic process |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0045723 | biological_process | positive regulation of fatty acid biosynthetic process |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 500 |
| Chain | Residue |
| B | SER7 |
| B | ALA9 |
| B | GLY10 |
| B | ARG54 |
| B | HOH663 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 501 |
| Chain | Residue |
| B | ARG174 |
| B | ARG177 |
| B | HIS178 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | GLY10 |
| A | ARG54 |
| A | HOH679 |
| A | SER7 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 503 |
| Chain | Residue |
| A | ARG177 |
| A | HIS178 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 504 |
| Chain | Residue |
| A | HIS205 |
| A | ASP206 |
| A | GLN207 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 505 |
| Chain | Residue |
| B | HIS205 |
| B | ASP206 |
| B | GLN207 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 506 |
| Chain | Residue |
| A | ASN81 |
| A | HOH625 |
| A | HOH626 |
| B | ASN81 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 136 |
| Details | Domain: {"description":"HTH gntR-type","evidences":[{"source":"HAMAP-Rule","id":"MF_00696","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 70 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PubMed","id":"11279025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11296236","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | Region: {"description":"Binds acyl-CoA","evidences":[{"source":"PubMed","id":"7836365","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11296236","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
