1HVU
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE COMPLEXED WITH A 33-BASE NUCLEOTIDE RNA PSEUDOKNOT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| D | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| D | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| E | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| E | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| G | 0003676 | molecular_function | nucleic acid binding |
| G | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| G | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| G | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| H | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| H | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| J | 0003676 | molecular_function | nucleic acid binding |
| J | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| J | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| J | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| K | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| K | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
| site_id | PS2 |
| Number of Residues | 3 |
| Details |
| Chain | Residue |
| D | ASP110 |
| D | ASP185 |
| D | ASP186 |
| site_id | PS3 |
| Number of Residues | 3 |
| Details |
| Chain | Residue |
| G | ASP110 |
| G | ASP185 |
| G | ASP186 |
| site_id | PS4 |
| Number of Residues | 3 |
| Details |
| Chain | Residue |
| J | ASP110 |
| J | ASP185 |
| J | ASP186 |
| site_id | PSE |
| Number of Residues | 3 |
| Details |
| Chain | Residue |
| A | ASP110 |
| A | ASP185 |
| A | ASP186 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 760 |
| Details | Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Region: {"description":"RT 'primer grip'"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 128 |
| Details | Motif: {"description":"Tryptophan repeat motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | Site: {"description":"Essential for RT p66/p51 heterodimerization"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Site: {"description":"Cleavage; by viral protease; partial"} |
| Chain | Residue | Details |
