1HVU

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE COMPLEXED WITH A 33-BASE NUCLEOTIDE RNA PSEUDOKNOT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process
D	0003676	molecular_function	nucleic acid binding
D	0003964	molecular_function	RNA-directed DNA polymerase activity
D	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
D	0006278	biological_process	RNA-templated DNA biosynthetic process
E	0003964	molecular_function	RNA-directed DNA polymerase activity
E	0006278	biological_process	RNA-templated DNA biosynthetic process
G	0003676	molecular_function	nucleic acid binding
G	0003964	molecular_function	RNA-directed DNA polymerase activity
G	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
G	0006278	biological_process	RNA-templated DNA biosynthetic process
H	0003964	molecular_function	RNA-directed DNA polymerase activity
H	0006278	biological_process	RNA-templated DNA biosynthetic process
J	0003676	molecular_function	nucleic acid binding
J	0003964	molecular_function	RNA-directed DNA polymerase activity
J	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
J	0006278	biological_process	RNA-templated DNA biosynthetic process
K	0003964	molecular_function	RNA-directed DNA polymerase activity
K	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from PDB Data

site_id	PS2
Number of Residues	3
Details

Chain	Residue
D	ASP110
D	ASP185
D	ASP186

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site_id	PS3
Number of Residues	3
Details

Chain	Residue
G	ASP110
G	ASP185
G	ASP186

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site_id	PS4
Number of Residues	3
Details

Chain	Residue
J	ASP110
J	ASP185
J	ASP186

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site_id	PSE
Number of Residues	3
Details

Chain	Residue
A	ASP110
A	ASP185
A	ASP186

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
B	VAL111
K	VAL111
K	ASP186
K	LEU187
B	ASP186
B	LEU187
E	VAL111
E	ASP186
E	LEU187
H	VAL111
H	ASP186
H	LEU187

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site_id	SWS_FT_FI2
Number of Residues	8
Details	SITE: Essential for RT p66/p51 heterodimerization

Chain	Residue	Details
B	TRP402
G	LEU479
G	SER499
G	LYS550
J	GLY444
J	LEU479
J	SER499
J	LYS550
B	GLU415
E	TRP402
E	GLU415
H	TRP402
H	GLU415
K	TRP402
K	GLU415
G	GLY444

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Cleavage; by viral protease => ECO:0000269|PubMed:2476069

Chain	Residue	Details
A	PRO1
D	PRO1
G	PRO1
J	PRO1

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site_id	SWS_FT_FI4
Number of Residues	8
Details	SITE: Essential for RT p66/p51 heterodimerization

Chain	Residue	Details
A	TRP402
A	GLU415
D	TRP402
D	GLU415
G	TRP402
G	GLU415
J	TRP402
J	GLU415

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site_id	SWS_FT_FI5
Number of Residues	4
Details	SITE: Cleavage; by viral protease; partial

Chain	Residue	Details
A	TYR441
D	TYR441
G	TYR441
J	TYR441

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