1HPL
HORSE PANCREATIC LIPASE. THE CRYSTAL STRUCTURE AT 2.3 ANGSTROMS RESOLUTION
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004806 | molecular_function | triglyceride lipase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0006629 | biological_process | lipid metabolic process |
A | 0016042 | biological_process | lipid catabolic process |
A | 0016298 | molecular_function | lipase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0042572 | biological_process | retinol metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0047376 | molecular_function | all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity |
A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
B | 0004806 | molecular_function | triglyceride lipase activity |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0006629 | biological_process | lipid metabolic process |
B | 0016042 | biological_process | lipid catabolic process |
B | 0016298 | molecular_function | lipase activity |
B | 0016787 | molecular_function | hydrolase activity |
B | 0042572 | biological_process | retinol metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0047376 | molecular_function | all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity |
B | 0052689 | molecular_function | carboxylic ester hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 960 |
Chain | Residue |
A | ASP195 |
A | HOH1074 |
A | HOH1261 |
A | GLU187 |
A | ARG190 |
A | ASP192 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 970 |
Chain | Residue |
B | GLU187 |
B | ARG190 |
B | ASP192 |
B | ASP195 |
B | HOH1079 |
B | HOH1162 |
site_id | ACT |
Number of Residues | 3 |
Details | ACTIVE SITE IN CHAIN A |
Chain | Residue |
A | SER152 |
A | ASP176 |
A | HIS263 |
site_id | BCT |
Number of Residues | 3 |
Details | ACTIVE SITE IN CHAIN B |
Chain | Residue |
B | SER152 |
B | ASP176 |
B | HIS263 |
Functional Information from PROSITE/UniProt
site_id | PS00120 |
Number of Residues | 10 |
Details | LIPASE_SER Lipases, serine active site. VHIIGHSLGS |
Chain | Residue | Details |
A | VAL146-SER155 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile |
Chain | Residue | Details |
A | SER152 | |
B | SER152 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Charge relay system |
Chain | Residue | Details |
A | ASP176 | |
A | HIS263 | |
B | ASP176 | |
B | HIS263 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: |
Chain | Residue | Details |
A | GLU187 | |
A | ARG190 | |
A | ASP192 | |
A | ASP195 | |
B | GLU187 | |
B | ARG190 | |
B | ASP192 | |
B | ASP195 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | a catalytic site defined by CSA, PubMed 8182745, 9109604 |
Chain | Residue | Details |
A | HIS263 | |
A | PHE77 | |
A | ASP176 | |
A | LEU153 |
site_id | CSA2 |
Number of Residues | 4 |
Details | a catalytic site defined by CSA, PubMed 8182745, 9109604 |
Chain | Residue | Details |
B | HIS263 | |
B | PHE77 | |
B | ASP176 | |
B | LEU153 |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 218 |
Chain | Residue | Details |
A | PHE77 | electrostatic stabiliser, hydrogen bond donor |
A | SER152 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
A | LEU153 | electrostatic stabiliser, hydrogen bond donor |
A | ASP176 | activator, hydrogen bond acceptor |
A | HIS263 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 218 |
Chain | Residue | Details |
B | PHE77 | electrostatic stabiliser, hydrogen bond donor |
B | SER152 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
B | LEU153 | electrostatic stabiliser, hydrogen bond donor |
B | ASP176 | activator, hydrogen bond acceptor |
B | HIS263 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |