1HOZ
CRYSTAL STRUCTURE OF AN INOSINE-ADENOSINE-GUANOSINE-PREFERRING NUCLEOSIDE HYDROLASE FROM TRYPANOSOMA VIVAX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006152 | biological_process | purine nucleoside catabolic process |
| A | 0008477 | molecular_function | purine nucleosidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006152 | biological_process | purine nucleoside catabolic process |
| B | 0008477 | molecular_function | purine nucleosidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 328 |
| Chain | Residue |
| A | ASP10 |
| A | ASP15 |
| A | THR137 |
| A | ASP261 |
| A | GOL1267 |
| A | HOH1376 |
| A | HOH1438 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CA B 328 |
| Chain | Residue |
| B | ASP15 |
| B | THR137 |
| B | ASP261 |
| B | HOH1304 |
| B | HOH1427 |
| B | HOH1428 |
| B | ASP10 |
| B | ASP14 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 1267 |
| Chain | Residue |
| A | ASP14 |
| A | THR137 |
| A | MET164 |
| A | ASN173 |
| A | GLU184 |
| A | ASN186 |
| A | ASP261 |
| A | CA328 |
| A | HOH1376 |
| A | HOH1438 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1268 |
| Chain | Residue |
| A | MET54 |
| A | PHE66 |
| A | PRO67 |
| A | ILE108 |
| A | GLU111 |
| A | ASN112 |
| A | TYR115 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1269 |
| Chain | Residue |
| A | PRO201 |
| A | GLY202 |
| B | LEU203 |
| B | PRO303 |
| B | LEU304 |
| B | HOH1316 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1270 |
| Chain | Residue |
| B | MET54 |
| B | PHE66 |
| B | PRO67 |
| B | GLU111 |
| B | ASN112 |
| B | TYR115 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1271 |
| Chain | Residue |
| A | ARG30 |
| A | LEU31 |
| A | PRO64 |
| A | LEU65 |
| A | HOH1316 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1272 |
| Chain | Residue |
| A | SER24 |
| A | ASN25 |
| A | THR26 |
| A | GLU27 |
| A | HOH1340 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1273 |
| Chain | Residue |
| A | LEU203 |
| A | PRO303 |
| A | LEU304 |
| A | PHE306 |
| A | HOH1331 |
| A | HOH1343 |
| A | HOH1418 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1274 |
| Chain | Residue |
| A | SER141 |
| A | ALA144 |
| A | TRP145 |
| A | ASP148 |
| A | SER193 |
| A | HOH1299 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1r4f |
| Chain | Residue | Details |
| A | ASN186 | |
| A | ASP10 | |
| A | TRP83 | |
| A | TRP260 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1r4f |
| Chain | Residue | Details |
| B | ASN186 | |
| B | ASP10 | |
| B | TRP83 | |
| B | TRP260 |
| site_id | MCSA1 |
| Number of Residues | 8 |
| Details | M-CSA 471 |
| Chain | Residue | Details |
| A | ASP10 | metal ligand, proton shuttle (general acid/base) |
| A | ASP15 | metal ligand |
| A | ASP40 | activator |
| A | TRP83 | activator |
| A | THR137 | metal ligand |
| A | ASN186 | activator, electrostatic stabiliser |
| A | TRP260 | activator, electrostatic stabiliser |
| A | ASP261 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 8 |
| Details | M-CSA 471 |
| Chain | Residue | Details |
| B | ASP10 | metal ligand, proton shuttle (general acid/base) |
| B | ASP15 | metal ligand |
| B | ASP40 | activator |
| B | TRP83 | activator |
| B | THR137 | metal ligand |
| B | ASN186 | activator, electrostatic stabiliser |
| B | TRP260 | activator, electrostatic stabiliser |
| B | ASP261 | metal ligand |
