1HLZ

CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0043565	molecular_function	sequence-specific DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 450

Chain	Residue
A	CYS1
A	CYS4
A	CYS18
A	CYS21

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 451

Chain	Residue
A	CYS56
A	CYS37
A	GLU41
A	ASN42
A	CYS43
A	CYS53

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 550

Chain	Residue
B	CYS1
B	CYS4
B	CYS18
B	CYS21

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 551

Chain	Residue
B	CYS37
B	CYS43
B	CYS53
B	CYS56

---

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CkvCg.Dvasgf.HYgvlaCegCkgFFrR

Chain	Residue	Details
A	CYS1-ARG27

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	152
Details	DNA binding: {"description":"Nuclear receptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	88
Details	Zinc finger: {"description":"NR C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; by KAT5","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---