Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAD A 600 |
| Chain | Residue |
| A | SER89 |
| A | PRO194 |
| A | TYR195 |
| A | HIS225 |
| A | CYS226 |
| A | GLY227 |
| A | ASN229 |
| A | ASN232 |
| A | THR253 |
| A | ALA254 |
| A | ARG255 |
| A | THR117 |
| A | ASP279 |
| A | HIS304 |
| A | ALA306 |
| A | TRP307 |
| A | FMT800 |
| A | HOH2076 |
| A | HOH2078 |
| A | HOH2111 |
| A | HOH2112 |
| A | HOH2113 |
| A | ILE169 |
| A | GLY170 |
| A | GLY172 |
| A | ARG173 |
| A | VAL174 |
| A | TYR192 |
| A | ASP193 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 700 |
| Chain | Residue |
| A | ARG152 |
| A | TYR308 |
| A | GLU310 |
| A | SER313 |
| A | ILE314 |
| A | ARG317 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT A 800 |
| Chain | Residue |
| A | ARG86 |
| A | SER89 |
| A | GLY90 |
| A | ARG255 |
| A | HIS304 |
| A | NAD600 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A 801 |
| Chain | Residue |
| A | HIS66 |
| A | ARG86 |
| A | ILE87 |
| A | TRP307 |
| A | MET316 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 28 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGIIGlGRVGqavalrakafgfn.VLfYD |
| Chain | Residue | Details |
| A | LEU166-ASP193 | |
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MRqGaFLVNtARGgLVD |
| Chain | Residue | Details |
| A | MET244-ASP260 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12805226","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16940172","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q13363","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1psd |
| Chain | Residue | Details |
| A | HIS304 | |
| A | GLU284 | |
