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1HJX

Ligand-induced signalling and conformational change of the 39 kD glycoprotein from human articular chondrocytes

Functional Information from GO Data
ChainGOidnamespacecontents
A0004568molecular_functionchitinase activity
A0005201molecular_functionextracellular matrix structural constituent
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005975biological_processcarbohydrate metabolic process
A0006032biological_processchitin catabolic process
A0006915biological_processapoptotic process
A0006954biological_processinflammatory response
A0007250biological_processactivation of NF-kappaB-inducing kinase activity
A0008061molecular_functionchitin binding
A0009612biological_processresponse to mechanical stimulus
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0030246molecular_functioncarbohydrate binding
A0030324biological_processlung development
A0031012cellular_componentextracellular matrix
A0032757biological_processpositive regulation of interleukin-8 production
A0034612biological_processresponse to tumor necrosis factor
A0035580cellular_componentspecific granule lumen
A0045766biological_processpositive regulation of angiogenesis
A0048471cellular_componentperinuclear region of cytoplasm
A0051216biological_processcartilage development
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0070062cellular_componentextracellular exosome
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070555biological_processresponse to interleukin-1
A0070741biological_processresponse to interleukin-6
A0071356biological_processcellular response to tumor necrosis factor
B0004568molecular_functionchitinase activity
B0005201molecular_functionextracellular matrix structural constituent
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005975biological_processcarbohydrate metabolic process
B0006032biological_processchitin catabolic process
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0007250biological_processactivation of NF-kappaB-inducing kinase activity
B0008061molecular_functionchitin binding
B0009612biological_processresponse to mechanical stimulus
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0030246molecular_functioncarbohydrate binding
B0030324biological_processlung development
B0031012cellular_componentextracellular matrix
B0032757biological_processpositive regulation of interleukin-8 production
B0034612biological_processresponse to tumor necrosis factor
B0035580cellular_componentspecific granule lumen
B0045766biological_processpositive regulation of angiogenesis
B0048471cellular_componentperinuclear region of cytoplasm
B0051216biological_processcartilage development
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0070062cellular_componentextracellular exosome
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070555biological_processresponse to interleukin-1
B0070741biological_processresponse to interleukin-6
B0071356biological_processcellular response to tumor necrosis factor
C0004568molecular_functionchitinase activity
C0005201molecular_functionextracellular matrix structural constituent
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005975biological_processcarbohydrate metabolic process
C0006032biological_processchitin catabolic process
C0006915biological_processapoptotic process
C0006954biological_processinflammatory response
C0007250biological_processactivation of NF-kappaB-inducing kinase activity
C0008061molecular_functionchitin binding
C0009612biological_processresponse to mechanical stimulus
C0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
C0030246molecular_functioncarbohydrate binding
C0030324biological_processlung development
C0031012cellular_componentextracellular matrix
C0032757biological_processpositive regulation of interleukin-8 production
C0034612biological_processresponse to tumor necrosis factor
C0035580cellular_componentspecific granule lumen
C0045766biological_processpositive regulation of angiogenesis
C0048471cellular_componentperinuclear region of cytoplasm
C0051216biological_processcartilage development
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0070062cellular_componentextracellular exosome
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0070555biological_processresponse to interleukin-1
C0070741biological_processresponse to interleukin-6
C0071356biological_processcellular response to tumor necrosis factor
D0004568molecular_functionchitinase activity
D0005201molecular_functionextracellular matrix structural constituent
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005975biological_processcarbohydrate metabolic process
D0006032biological_processchitin catabolic process
D0006915biological_processapoptotic process
D0006954biological_processinflammatory response
D0007250biological_processactivation of NF-kappaB-inducing kinase activity
D0008061molecular_functionchitin binding
D0009612biological_processresponse to mechanical stimulus
D0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
D0030246molecular_functioncarbohydrate binding
D0030324biological_processlung development
D0031012cellular_componentextracellular matrix
D0032757biological_processpositive regulation of interleukin-8 production
D0034612biological_processresponse to tumor necrosis factor
D0035580cellular_componentspecific granule lumen
D0045766biological_processpositive regulation of angiogenesis
D0048471cellular_componentperinuclear region of cytoplasm
D0051216biological_processcartilage development
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0070062cellular_componentextracellular exosome
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0070555biological_processresponse to interleukin-1
D0070741biological_processresponse to interleukin-6
D0071356biological_processcellular response to tumor necrosis factor
Functional Information from PROSITE/UniProt
site_idPS00217
Number of Residues26
DetailsSUGAR_TRANSPORT_2 Sugar transport proteins signature 2. FhGAWrGTtghhsplFrgQedaspdR
ChainResidueDetails
APHE208-ARG233

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01258
ChainResidueDetails
BMET204
BTRP352
CGLU70
CGLY97
CTYR141
CMET204
CTRP352
DGLU70
DGLY97
DTYR141
DMET204
DTRP352
AGLY97
ATYR141
AMET204
ATRP352
BGLU70
BGLY97
BTYR141
AGLU70

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AARG263
BARG263
CARG263
DARG263

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12775711
ChainResidueDetails
AASN60
BASN60
CASN60
DASN60

218500

PDB entries from 2024-04-17

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