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1HIG

THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001774biological_processmicroglial cell activation
A0001819biological_processpositive regulation of cytokine production
A0002250biological_processadaptive immune response
A0002281biological_processmacrophage activation involved in immune response
A0005125molecular_functioncytokine activity
A0005133molecular_functiontype II interferon receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006915biological_processapoptotic process
A0006955biological_processimmune response
A0006959biological_processhumoral immune response
A0007166biological_processcell surface receptor signaling pathway
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0008284biological_processpositive regulation of cell population proliferation
A0009615biological_processresponse to virus
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010634biological_processpositive regulation of epithelial cell migration
A0030225biological_processmacrophage differentiation
A0030857biological_processnegative regulation of epithelial cell differentiation
A0032700biological_processnegative regulation of interleukin-17 production
A0032722biological_processpositive regulation of chemokine production
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032735biological_processpositive regulation of interleukin-12 production
A0032747biological_processpositive regulation of interleukin-23 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032834biological_processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
A0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
A0034393biological_processpositive regulation of smooth muscle cell apoptotic process
A0038096biological_processFc-gamma receptor signaling pathway involved in phagocytosis
A0038196biological_processtype III interferon-mediated signaling pathway
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0045348biological_processpositive regulation of MHC class II biosynthetic process
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045672biological_processpositive regulation of osteoclast differentiation
A0045785biological_processpositive regulation of cell adhesion
A0045821biological_processpositive regulation of glycolytic process
A0045892biological_processnegative regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048143biological_processastrocyte activation
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0050729biological_processpositive regulation of inflammatory response
A0050766biological_processpositive regulation of phagocytosis
A0050769biological_processpositive regulation of neurogenesis
A0050796biological_processregulation of insulin secretion
A0051044biological_processpositive regulation of membrane protein ectodomain proteolysis
A0051607biological_processdefense response to virus
A0060333biological_processtype II interferon-mediated signaling pathway
A0060552biological_processpositive regulation of fructose 1,6-bisphosphate metabolic process
A0060557biological_processpositive regulation of vitamin D biosynthetic process
A0097191biological_processextrinsic apoptotic signaling pathway
A0097696biological_processcell surface receptor signaling pathway via STAT
A0098586biological_processcellular response to virus
A0150076biological_processneuroinflammatory response
A1900222biological_processnegative regulation of amyloid-beta clearance
A1900451biological_processpositive regulation of glutamate receptor signaling pathway
A1901857biological_processpositive regulation of cellular respiration
A1902004biological_processpositive regulation of amyloid-beta formation
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1903543biological_processpositive regulation of exosomal secretion
A1904440biological_processpositive regulation of iron ion import across plasma membrane
A2000309biological_processpositive regulation of tumor necrosis factor (ligand) superfamily member 11 production
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001774biological_processmicroglial cell activation
B0001819biological_processpositive regulation of cytokine production
B0002250biological_processadaptive immune response
B0002281biological_processmacrophage activation involved in immune response
B0005125molecular_functioncytokine activity
B0005133molecular_functiontype II interferon receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006915biological_processapoptotic process
B0006955biological_processimmune response
B0006959biological_processhumoral immune response
B0007166biological_processcell surface receptor signaling pathway
B0007259biological_processcell surface receptor signaling pathway via JAK-STAT
B0008284biological_processpositive regulation of cell population proliferation
B0009615biological_processresponse to virus
B0010508biological_processpositive regulation of autophagy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010634biological_processpositive regulation of epithelial cell migration
B0030225biological_processmacrophage differentiation
B0030857biological_processnegative regulation of epithelial cell differentiation
B0032700biological_processnegative regulation of interleukin-17 production
B0032722biological_processpositive regulation of chemokine production
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032735biological_processpositive regulation of interleukin-12 production
B0032747biological_processpositive regulation of interleukin-23 production
B0032755biological_processpositive regulation of interleukin-6 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0032834biological_processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
B0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
B0034393biological_processpositive regulation of smooth muscle cell apoptotic process
B0038096biological_processFc-gamma receptor signaling pathway involved in phagocytosis
B0038196biological_processtype III interferon-mediated signaling pathway
B0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
B0045348biological_processpositive regulation of MHC class II biosynthetic process
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0045672biological_processpositive regulation of osteoclast differentiation
B0045785biological_processpositive regulation of cell adhesion
B0045821biological_processpositive regulation of glycolytic process
B0045892biological_processnegative regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048143biological_processastrocyte activation
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0050729biological_processpositive regulation of inflammatory response
B0050766biological_processpositive regulation of phagocytosis
B0050769biological_processpositive regulation of neurogenesis
B0050796biological_processregulation of insulin secretion
B0051044biological_processpositive regulation of membrane protein ectodomain proteolysis
B0051607biological_processdefense response to virus
B0060333biological_processtype II interferon-mediated signaling pathway
B0060552biological_processpositive regulation of fructose 1,6-bisphosphate metabolic process
B0060557biological_processpositive regulation of vitamin D biosynthetic process
B0097191biological_processextrinsic apoptotic signaling pathway
B0097696biological_processcell surface receptor signaling pathway via STAT
B0098586biological_processcellular response to virus
B0150076biological_processneuroinflammatory response
B1900222biological_processnegative regulation of amyloid-beta clearance
B1900451biological_processpositive regulation of glutamate receptor signaling pathway
B1901857biological_processpositive regulation of cellular respiration
B1902004biological_processpositive regulation of amyloid-beta formation
B1903078biological_processpositive regulation of protein localization to plasma membrane
B1903543biological_processpositive regulation of exosomal secretion
B1904440biological_processpositive regulation of iron ion import across plasma membrane
B2000309biological_processpositive regulation of tumor necrosis factor (ligand) superfamily member 11 production
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001774biological_processmicroglial cell activation
C0001819biological_processpositive regulation of cytokine production
C0002250biological_processadaptive immune response
C0002281biological_processmacrophage activation involved in immune response
C0005125molecular_functioncytokine activity
C0005133molecular_functiontype II interferon receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006915biological_processapoptotic process
C0006955biological_processimmune response
C0006959biological_processhumoral immune response
C0007166biological_processcell surface receptor signaling pathway
C0007259biological_processcell surface receptor signaling pathway via JAK-STAT
C0008284biological_processpositive regulation of cell population proliferation
C0009615biological_processresponse to virus
C0010508biological_processpositive regulation of autophagy
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010634biological_processpositive regulation of epithelial cell migration
C0030225biological_processmacrophage differentiation
C0030857biological_processnegative regulation of epithelial cell differentiation
C0032700biological_processnegative regulation of interleukin-17 production
C0032722biological_processpositive regulation of chemokine production
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032735biological_processpositive regulation of interleukin-12 production
C0032747biological_processpositive regulation of interleukin-23 production
C0032755biological_processpositive regulation of interleukin-6 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0032834biological_processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
C0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
C0034393biological_processpositive regulation of smooth muscle cell apoptotic process
C0038096biological_processFc-gamma receptor signaling pathway involved in phagocytosis
C0038196biological_processtype III interferon-mediated signaling pathway
C0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
C0045348biological_processpositive regulation of MHC class II biosynthetic process
C0045429biological_processpositive regulation of nitric oxide biosynthetic process
C0045672biological_processpositive regulation of osteoclast differentiation
C0045785biological_processpositive regulation of cell adhesion
C0045821biological_processpositive regulation of glycolytic process
C0045892biological_processnegative regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048143biological_processastrocyte activation
C0048662biological_processnegative regulation of smooth muscle cell proliferation
C0050729biological_processpositive regulation of inflammatory response
C0050766biological_processpositive regulation of phagocytosis
C0050769biological_processpositive regulation of neurogenesis
C0050796biological_processregulation of insulin secretion
C0051044biological_processpositive regulation of membrane protein ectodomain proteolysis
C0051607biological_processdefense response to virus
C0060333biological_processtype II interferon-mediated signaling pathway
C0060552biological_processpositive regulation of fructose 1,6-bisphosphate metabolic process
C0060557biological_processpositive regulation of vitamin D biosynthetic process
C0097191biological_processextrinsic apoptotic signaling pathway
C0097696biological_processcell surface receptor signaling pathway via STAT
C0098586biological_processcellular response to virus
C0150076biological_processneuroinflammatory response
C1900222biological_processnegative regulation of amyloid-beta clearance
C1900451biological_processpositive regulation of glutamate receptor signaling pathway
C1901857biological_processpositive regulation of cellular respiration
C1902004biological_processpositive regulation of amyloid-beta formation
C1903078biological_processpositive regulation of protein localization to plasma membrane
C1903543biological_processpositive regulation of exosomal secretion
C1904440biological_processpositive regulation of iron ion import across plasma membrane
C2000309biological_processpositive regulation of tumor necrosis factor (ligand) superfamily member 11 production
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001774biological_processmicroglial cell activation
D0001819biological_processpositive regulation of cytokine production
D0002250biological_processadaptive immune response
D0002281biological_processmacrophage activation involved in immune response
D0005125molecular_functioncytokine activity
D0005133molecular_functiontype II interferon receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006915biological_processapoptotic process
D0006955biological_processimmune response
D0006959biological_processhumoral immune response
D0007166biological_processcell surface receptor signaling pathway
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0008284biological_processpositive regulation of cell population proliferation
D0009615biological_processresponse to virus
D0010508biological_processpositive regulation of autophagy
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010634biological_processpositive regulation of epithelial cell migration
D0030225biological_processmacrophage differentiation
D0030857biological_processnegative regulation of epithelial cell differentiation
D0032700biological_processnegative regulation of interleukin-17 production
D0032722biological_processpositive regulation of chemokine production
D0032731biological_processpositive regulation of interleukin-1 beta production
D0032735biological_processpositive regulation of interleukin-12 production
D0032747biological_processpositive regulation of interleukin-23 production
D0032755biological_processpositive regulation of interleukin-6 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0032834biological_processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
D0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
D0034393biological_processpositive regulation of smooth muscle cell apoptotic process
D0038096biological_processFc-gamma receptor signaling pathway involved in phagocytosis
D0038196biological_processtype III interferon-mediated signaling pathway
D0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
D0045348biological_processpositive regulation of MHC class II biosynthetic process
D0045429biological_processpositive regulation of nitric oxide biosynthetic process
D0045672biological_processpositive regulation of osteoclast differentiation
D0045785biological_processpositive regulation of cell adhesion
D0045821biological_processpositive regulation of glycolytic process
D0045892biological_processnegative regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048143biological_processastrocyte activation
D0048662biological_processnegative regulation of smooth muscle cell proliferation
D0050729biological_processpositive regulation of inflammatory response
D0050766biological_processpositive regulation of phagocytosis
D0050769biological_processpositive regulation of neurogenesis
D0050796biological_processregulation of insulin secretion
D0051044biological_processpositive regulation of membrane protein ectodomain proteolysis
D0051607biological_processdefense response to virus
D0060333biological_processtype II interferon-mediated signaling pathway
D0060552biological_processpositive regulation of fructose 1,6-bisphosphate metabolic process
D0060557biological_processpositive regulation of vitamin D biosynthetic process
D0097191biological_processextrinsic apoptotic signaling pathway
D0097696biological_processcell surface receptor signaling pathway via STAT
D0098586biological_processcellular response to virus
D0150076biological_processneuroinflammatory response
D1900222biological_processnegative regulation of amyloid-beta clearance
D1900451biological_processpositive regulation of glutamate receptor signaling pathway
D1901857biological_processpositive regulation of cellular respiration
D1902004biological_processpositive regulation of amyloid-beta formation
D1903078biological_processpositive regulation of protein localization to plasma membrane
D1903543biological_processpositive regulation of exosomal secretion
D1904440biological_processpositive regulation of iron ion import across plasma membrane
D2000309biological_processpositive regulation of tumor necrosis factor (ligand) superfamily member 11 production
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsModified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"3109913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6427223","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"6427223","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine; in dimeric form","evidences":[{"source":"PubMed","id":"6427223","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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