Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1HG3

Crystal structure of tetrameric TIM from Pyrococcus woesei.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0019563	biological_process	glycerol catabolic process
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0019563	biological_process	glycerol catabolic process
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
C	0004807	molecular_function	triose-phosphate isomerase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0016853	molecular_function	isomerase activity
C	0019563	biological_process	glycerol catabolic process
C	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
D	0004807	molecular_function	triose-phosphate isomerase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0016853	molecular_function	isomerase activity
D	0019563	biological_process	glycerol catabolic process
D	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
E	0004807	molecular_function	triose-phosphate isomerase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006094	biological_process	gluconeogenesis
E	0006096	biological_process	glycolytic process
E	0016853	molecular_function	isomerase activity
E	0019563	biological_process	glycerol catabolic process
E	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
F	0004807	molecular_function	triose-phosphate isomerase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006094	biological_process	gluconeogenesis
F	0006096	biological_process	glycolytic process
F	0016853	molecular_function	isomerase activity
F	0019563	biological_process	glycerol catabolic process
F	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
G	0004807	molecular_function	triose-phosphate isomerase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006094	biological_process	gluconeogenesis
G	0006096	biological_process	glycolytic process
G	0016853	molecular_function	isomerase activity
G	0019563	biological_process	glycerol catabolic process
G	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
H	0004807	molecular_function	triose-phosphate isomerase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006094	biological_process	gluconeogenesis
H	0006096	biological_process	glycolytic process
H	0016853	molecular_function	isomerase activity
H	0019563	biological_process	glycerol catabolic process
H	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3PP A1226

Chain	Residue
A	ASN12
A	SER206
A	HOH2036
A	HOH2037
A	LYS14
A	HIS96
A	GLU144
A	ILE149
A	ALA183
A	GLY184
A	LEU204
A	ALA205

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3PP B1226

Chain	Residue
B	ASN12
B	LYS14
B	HIS96
B	GLU144
B	ILE149
B	ALA183
B	GLY184
B	LEU203
B	LEU204
B	ALA205
B	SER206
B	HOH2036

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 3PP C1226

Chain	Residue
C	ASN12
C	LYS14
C	HIS96
C	GLU144
C	ILE149
C	ALA183
C	GLY184
C	LEU204
C	ALA205
C	SER206
C	HOH2004
C	HOH2048
C	HOH2052

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3PP D1226

Chain	Residue
D	ASN12
D	LYS14
D	HIS96
D	GLU144
D	ILE149
D	GLY184
D	LEU203
D	LEU204
D	ALA205
D	SER206
D	GLY207
D	HOH2044

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3PP E1226

Chain	Residue
E	ASN12
E	LYS14
E	HIS96
E	GLU144
E	ILE149
E	ALA183
E	GLY184
E	LEU203
E	LEU204
E	ALA205
E	SER206
E	HOH2043

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 3PP F1226

Chain	Residue
F	ASN12
F	LYS14
F	HIS96
F	GLU144
F	ILE149
F	ALA183
F	GLY184
F	LEU203
F	LEU204
F	ALA205
F	SER206

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 3PP G1226

Chain	Residue
G	ASN12
G	LYS14
G	HIS96
G	GLU144
G	ILE149
G	ALA183
G	GLY184
G	LEU204
G	ALA205
G	SER206
G	HOH2045
G	HOH2046

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 3PP H1226

Chain	Residue
H	ASN12
H	LYS14
H	HIS96
H	GLU144
H	ILE149
H	ALA183
H	GLY184
H	LEU203
H	LEU204
H	ALA205
H	SER206
H	HOH2003
H	HOH2044

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. AVEPPELIGTG

Chain	Residue	Details
A	ALA142-GLY152

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Electrophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11243785","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00147","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
A	LYS14
A	HIS96
A	GLU144
A	GLY150
A	ASN12

site_id	CSA2
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
B	LYS14
B	HIS96
B	GLU144
B	GLY150
B	ASN12

site_id	CSA3
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
C	LYS14
C	HIS96
C	GLU144
C	GLY150
C	ASN12

site_id	CSA4
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
D	LYS14
D	HIS96
D	GLU144
D	GLY150
D	ASN12

site_id	CSA5
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
E	LYS14
E	HIS96
E	GLU144
E	GLY150
E	ASN12

site_id	CSA6
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
F	LYS14
F	HIS96
F	GLU144
F	GLY150
F	ASN12

site_id	CSA7
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
G	LYS14
G	HIS96
G	GLU144
G	GLY150
G	ASN12

site_id	CSA8
Number of Residues	5
Details	Annotated By Reference To The Literature 1hti

Chain	Residue	Details
H	LYS14
H	HIS96
H	GLU144
H	GLY150
H	ASN12

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)