1HFC
1.56 ANGSTROM STRUCTURE OF MATURE TRUNCATED HUMAN FIBROBLAST COLLAGENASE
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 275 |
Chain | Residue |
A | HIS218 |
A | HIS222 |
A | HIS228 |
A | PLH280 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 276 |
Chain | Residue |
A | HIS168 |
A | ASP170 |
A | HIS183 |
A | HIS196 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 277 |
Chain | Residue |
A | GLY176 |
A | GLY178 |
A | ASN180 |
A | ASP198 |
A | GLU201 |
A | ASP175 |
site_id | AC4 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE PLH A 280 |
Chain | Residue |
A | ASN171 |
A | GLY179 |
A | ASN180 |
A | LEU181 |
A | ALA182 |
A | PHE207 |
A | TYR210 |
A | HIS218 |
A | GLU219 |
A | HIS222 |
A | HIS228 |
A | TYR237 |
A | PRO238 |
A | SER239 |
A | TYR240 |
A | PHE242 |
A | ZN275 |
A | HOH295 |
A | HOH312 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL |
Chain | Residue | Details |
A | VAL215-LEU224 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | GLU219 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP124 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP194 | |
A | ASP158 | |
A | GLY190 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | HIS218 | |
A | HIS222 | |
A | HIS228 | |
A | HIS168 | |
A | HIS196 | |
A | HIS183 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP170 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP175 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLY176 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLY178 | |
A | ASN180 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLY192 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:4AYK, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | ASP198 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:8031754, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLU199 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219, ECO:0007744|PDB:1AYK, ECO:0007744|PDB:1CGE, ECO:0007744|PDB:1CGF, ECO:0007744|PDB:1CGL, ECO:0007744|PDB:1HFC, ECO:0007744|PDB:1SU3, ECO:0007744|PDB:2AYK, ECO:0007744|PDB:2CLT, ECO:0007744|PDB:2J0T, ECO:0007744|PDB:2TCL, ECO:0007744|PDB:3AYK, ECO:0007744|PDB:3SHI, ECO:0007744|PDB:4AUO, ECO:0007744|PDB:966C |
Chain | Residue | Details |
A | GLU201 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | SITE: Not glycosylated => ECO:0000269|PubMed:10092871 |
Chain | Residue | Details |
A | ASN143 |
site_id | SWS_FT_FI14 |
Number of Residues | 1 |
Details | SITE: Cleavage; by autolysis => ECO:0000269|PubMed:2557822 |
Chain | Residue | Details |
A | PRO269 |
site_id | SWS_FT_FI15 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10092871 |
Chain | Residue | Details |
A | ASN120 |