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1HFC

1.56 ANGSTROM STRUCTURE OF MATURE TRUNCATED HUMAN FIBROBLAST COLLAGENASE

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0031012cellular_componentextracellular matrix
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 275
ChainResidue
AHIS218
AHIS222
AHIS228
APLH280

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 276
ChainResidue
AHIS168
AASP170
AHIS183
AHIS196

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 277
ChainResidue
AGLY176
AGLY178
AASN180
AASP198
AGLU201
AASP175

site_idAC4
Number of Residues19
DetailsBINDING SITE FOR RESIDUE PLH A 280
ChainResidue
AASN171
AGLY179
AASN180
ALEU181
AALA182
APHE207
ATYR210
AHIS218
AGLU219
AHIS222
AHIS228
ATYR237
APRO238
ASER239
ATYR240
APHE242
AZN275
AHOH295
AHOH312

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL
ChainResidueDetails
AVAL215-LEU224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15611040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7656013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8090713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8278810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9484219","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CGL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HFC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2J0T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2TCL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AYK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AUO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"966C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues1
DetailsSite: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"10092871","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000105","evidences":[{"source":"PubMed","id":"10092871","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
AMET236
AGLU219

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
AGLU219

243083

PDB entries from 2025-10-15

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