Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1HFB

Crystal structure of the tyrosine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Saccharomyces cerevisiae complexed with phosphoenolpyruvate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003849	molecular_function	3-deoxy-7-phosphoheptulonate synthase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0008652	biological_process	amino acid biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0009423	biological_process	chorismate biosynthetic process
A	0016740	molecular_function	transferase activity
B	0003849	molecular_function	3-deoxy-7-phosphoheptulonate synthase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0008652	biological_process	amino acid biosynthetic process
B	0009058	biological_process	biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0009423	biological_process	chorismate biosynthetic process
B	0016740	molecular_function	transferase activity
C	0003849	molecular_function	3-deoxy-7-phosphoheptulonate synthase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0008652	biological_process	amino acid biosynthetic process
C	0009058	biological_process	biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0009423	biological_process	chorismate biosynthetic process
C	0016740	molecular_function	transferase activity
D	0003849	molecular_function	3-deoxy-7-phosphoheptulonate synthase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0008652	biological_process	amino acid biosynthetic process
D	0009058	biological_process	biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0009423	biological_process	chorismate biosynthetic process
D	0016740	molecular_function	transferase activity
E	0003849	molecular_function	3-deoxy-7-phosphoheptulonate synthase activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0008652	biological_process	amino acid biosynthetic process
E	0009058	biological_process	biosynthetic process
E	0009073	biological_process	aromatic amino acid family biosynthetic process
E	0009423	biological_process	chorismate biosynthetic process
E	0016740	molecular_function	transferase activity
F	0003849	molecular_function	3-deoxy-7-phosphoheptulonate synthase activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0008652	biological_process	amino acid biosynthetic process
F	0009058	biological_process	biosynthetic process
F	0009073	biological_process	aromatic amino acid family biosynthetic process
F	0009423	biological_process	chorismate biosynthetic process
F	0016740	molecular_function	transferase activity
G	0003849	molecular_function	3-deoxy-7-phosphoheptulonate synthase activity
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0008652	biological_process	amino acid biosynthetic process
G	0009058	biological_process	biosynthetic process
G	0009073	biological_process	aromatic amino acid family biosynthetic process
G	0009423	biological_process	chorismate biosynthetic process
G	0016740	molecular_function	transferase activity
H	0003849	molecular_function	3-deoxy-7-phosphoheptulonate synthase activity
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0008652	biological_process	amino acid biosynthetic process
H	0009058	biological_process	biosynthetic process
H	0009073	biological_process	aromatic amino acid family biosynthetic process
H	0009423	biological_process	chorismate biosynthetic process
H	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PEP A 500

Chain	Residue
A	ARG107
A	HOH2039
A	HOH2072
A	HOH2187
A	TYR109
A	LYS112
A	GLY178
A	ALA179
A	ARG180
A	LYS201
A	ARG249
A	HIS282

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PEP B 500

Chain	Residue
B	ARG107
B	TYR109
B	LYS112
B	GLY178
B	ALA179
B	ARG180
B	LYS201
B	ARG249
B	HIS282
B	HOH2044
B	HOH2079
B	HOH2202
B	HOH2203
B	HOH2204

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PEP C 500

Chain	Residue
C	ARG107
C	TYR109
C	LYS112
C	GLY178
C	ALA179
C	ARG180
C	LYS201
C	ARG249
C	HIS282
C	HOH2040
C	HOH2141
C	HOH2142

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PEP D 500

Chain	Residue
D	ARG107
D	TYR109
D	LYS112
D	GLY178
D	ALA179
D	ARG180
D	LYS201
D	ARG249
D	HIS282
D	HOH2057
D	HOH2104
D	HOH2206
D	HOH2207

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PEP E 500

Chain	Residue
E	ARG107
E	TYR109
E	LYS112
E	GLY178
E	ALA179
E	ARG180
E	LYS201
E	ARG249
E	HIS282
E	HOH2020
E	HOH2046
E	HOH2100
E	HOH2101

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PEP F 500

Chain	Residue
F	ARG107
F	TYR109
F	LYS112
F	GLY178
F	ALA179
F	ARG180
F	LYS201
F	ARG249
F	HIS282
F	HOH2045
F	HOH2094
F	HOH2167
F	HOH2168

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PEP G 500

Chain	Residue
G	ARG107
G	TYR109
G	LYS112
G	GLU158
G	GLY178
G	ALA179
G	LYS201
G	ARG249
G	HIS282
G	HOH2034
G	HOH2062
G	HOH2099

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PEP H 500

Chain	Residue
H	HOH2074
H	HOH2082
H	HOH2143
H	ARG107
H	TYR109
H	LYS112
H	GLY178
H	ALA179
H	ARG180
H	LYS201
H	ARG249
H	HIS282
H	HOH2041

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1q3n

Chain	Residue	Details
A	HIS282

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1q3n

Chain	Residue	Details
B	HIS282

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1q3n

Chain	Residue	Details
C	HIS282

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1q3n

Chain	Residue	Details
D	HIS282

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1q3n

Chain	Residue	Details
E	HIS282

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1q3n

Chain	Residue	Details
F	HIS282

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1q3n

Chain	Residue	Details
G	HIS282

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1q3n

Chain	Residue	Details
H	HIS282

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)