1HFB
Crystal structure of the tyrosine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Saccharomyces cerevisiae complexed with phosphoenolpyruvate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| C | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0009423 | biological_process | chorismate biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| D | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0009423 | biological_process | chorismate biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| E | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0009058 | biological_process | biosynthetic process |
| E | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| E | 0009423 | biological_process | chorismate biosynthetic process |
| E | 0016740 | molecular_function | transferase activity |
| F | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009058 | biological_process | biosynthetic process |
| F | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| F | 0009423 | biological_process | chorismate biosynthetic process |
| F | 0016740 | molecular_function | transferase activity |
| G | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| G | 0005634 | cellular_component | nucleus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0009058 | biological_process | biosynthetic process |
| G | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| G | 0009423 | biological_process | chorismate biosynthetic process |
| G | 0016740 | molecular_function | transferase activity |
| H | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| H | 0005634 | cellular_component | nucleus |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0009058 | biological_process | biosynthetic process |
| H | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| H | 0009423 | biological_process | chorismate biosynthetic process |
| H | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PEP A 500 |
| Chain | Residue |
| A | ARG107 |
| A | HOH2039 |
| A | HOH2072 |
| A | HOH2187 |
| A | TYR109 |
| A | LYS112 |
| A | GLY178 |
| A | ALA179 |
| A | ARG180 |
| A | LYS201 |
| A | ARG249 |
| A | HIS282 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PEP B 500 |
| Chain | Residue |
| B | ARG107 |
| B | TYR109 |
| B | LYS112 |
| B | GLY178 |
| B | ALA179 |
| B | ARG180 |
| B | LYS201 |
| B | ARG249 |
| B | HIS282 |
| B | HOH2044 |
| B | HOH2079 |
| B | HOH2202 |
| B | HOH2203 |
| B | HOH2204 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PEP C 500 |
| Chain | Residue |
| C | ARG107 |
| C | TYR109 |
| C | LYS112 |
| C | GLY178 |
| C | ALA179 |
| C | ARG180 |
| C | LYS201 |
| C | ARG249 |
| C | HIS282 |
| C | HOH2040 |
| C | HOH2141 |
| C | HOH2142 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PEP D 500 |
| Chain | Residue |
| D | ARG107 |
| D | TYR109 |
| D | LYS112 |
| D | GLY178 |
| D | ALA179 |
| D | ARG180 |
| D | LYS201 |
| D | ARG249 |
| D | HIS282 |
| D | HOH2057 |
| D | HOH2104 |
| D | HOH2206 |
| D | HOH2207 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PEP E 500 |
| Chain | Residue |
| E | ARG107 |
| E | TYR109 |
| E | LYS112 |
| E | GLY178 |
| E | ALA179 |
| E | ARG180 |
| E | LYS201 |
| E | ARG249 |
| E | HIS282 |
| E | HOH2020 |
| E | HOH2046 |
| E | HOH2100 |
| E | HOH2101 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PEP F 500 |
| Chain | Residue |
| F | ARG107 |
| F | TYR109 |
| F | LYS112 |
| F | GLY178 |
| F | ALA179 |
| F | ARG180 |
| F | LYS201 |
| F | ARG249 |
| F | HIS282 |
| F | HOH2045 |
| F | HOH2094 |
| F | HOH2167 |
| F | HOH2168 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PEP G 500 |
| Chain | Residue |
| G | ARG107 |
| G | TYR109 |
| G | LYS112 |
| G | GLU158 |
| G | GLY178 |
| G | ALA179 |
| G | LYS201 |
| G | ARG249 |
| G | HIS282 |
| G | HOH2034 |
| G | HOH2062 |
| G | HOH2099 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PEP H 500 |
| Chain | Residue |
| H | HOH2074 |
| H | HOH2082 |
| H | HOH2143 |
| H | ARG107 |
| H | TYR109 |
| H | LYS112 |
| H | GLY178 |
| H | ALA179 |
| H | ARG180 |
| H | LYS201 |
| H | ARG249 |
| H | HIS282 |
| H | HOH2041 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 | |
| C | SER2 | |
| D | SER2 | |
| E | SER2 | |
| F | SER2 | |
| G | SER2 | |
| H | SER2 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| A | HIS282 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| B | HIS282 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| C | HIS282 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| D | HIS282 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| E | HIS282 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| F | HIS282 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| G | HIS282 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| H | HIS282 |
