1HDO
Human biliverdin IX beta reductase: NADP complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004074 | molecular_function | biliverdin reductase [NAD(P)+] activity |
A | 0005515 | molecular_function | protein binding |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0008752 | molecular_function | FMN reductase (NAD(P)H) activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016740 | molecular_function | transferase activity |
A | 0030219 | biological_process | megakaryocyte differentiation |
A | 0035605 | molecular_function | peptidyl-cysteine S-nitrosylase activity |
A | 0042167 | biological_process | heme catabolic process |
A | 0042602 | molecular_function | riboflavin reductase (NADPH) activity |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0046627 | biological_process | negative regulation of insulin receptor signaling pathway |
A | 0052873 | molecular_function | FMN reductase (NADPH) activity |
A | 0052874 | molecular_function | FMN reductase (NADH) activity |
A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 37 |
Details | BINDING SITE FOR RESIDUE NAP A 500 |
Chain | Residue |
A | GLY10 |
A | LEU74 |
A | LEU75 |
A | GLY76 |
A | ARG78 |
A | MET87 |
A | CYS109 |
A | THR110 |
A | SER111 |
A | HIS132 |
A | PRO151 |
A | THR12 |
A | PRO152 |
A | HIS153 |
A | ILE154 |
A | HOH2076 |
A | HOH2273 |
A | HOH2347 |
A | HOH2348 |
A | HOH2349 |
A | HOH2350 |
A | HOH2351 |
A | GLY13 |
A | HOH2352 |
A | HOH2353 |
A | HOH2354 |
A | HOH2355 |
A | HOH2356 |
A | HOH2357 |
A | HOH2358 |
A | HOH2359 |
A | GLN14 |
A | THR15 |
A | ARG35 |
A | ARG39 |
A | ASP54 |
A | VAL55 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: S-nitroso-cysteine intermediate; for S-nitroso-CoA-dependent nitrosyltransferase activity => ECO:0000269|PubMed:38056462 |
Chain | Residue | Details |
A | THR110 | |
A | LEU189 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11224564, ECO:0000269|PubMed:29487133, ECO:0000269|PubMed:34957824, ECO:0007744|PDB:1HDO, ECO:0007744|PDB:5OOG, ECO:0007744|PDB:5OOH, ECO:0007744|PDB:7ER7 |
Chain | Residue | Details |
A | ALA11 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11224564, ECO:0000269|PubMed:29487133, ECO:0000269|PubMed:32246827, ECO:0000269|PubMed:34957824, ECO:0007744|PDB:1HDO, ECO:0007744|PDB:1HE2, ECO:0007744|PDB:1HE3, ECO:0007744|PDB:1HE4, ECO:0007744|PDB:1HE5, ECO:0007744|PDB:5OOG, ECO:0007744|PDB:5OOH, ECO:0007744|PDB:6OPL, ECO:0007744|PDB:7ER6, ECO:0007744|PDB:7ER7, ECO:0007744|PDB:7ER8, ECO:0007744|PDB:7ER9, ECO:0007744|PDB:7ERA, ECO:0007744|PDB:7ERB, ECO:0007744|PDB:7ERC, ECO:0007744|PDB:7ERD, ECO:0007744|PDB:7ERE |
Chain | Residue | Details |
A | GLY13 | |
A | GLY16 | |
A | ASP36 | |
A | VAL55 | |
A | LEU56 | |
A | THR77 | |
A | ASN79 | |
A | SER88 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11224564, ECO:0000269|PubMed:32246827, ECO:0000269|PubMed:34957824, ECO:0007744|PDB:1HDO, ECO:0007744|PDB:1HE2, ECO:0007744|PDB:1HE3, ECO:0007744|PDB:1HE4, ECO:0007744|PDB:1HE5, ECO:0007744|PDB:5OOG, ECO:0007744|PDB:5OOH, ECO:0007744|PDB:6OPL, ECO:0007744|PDB:7ER6, ECO:0007744|PDB:7ER7, ECO:0007744|PDB:7ER8, ECO:0007744|PDB:7ER9, ECO:0007744|PDB:7ERA, ECO:0007744|PDB:7ERB, ECO:0007744|PDB:7ERC, ECO:0007744|PDB:7ERD, ECO:0007744|PDB:7ERE |
Chain | Residue | Details |
A | GLN14 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11224564, ECO:0000269|PubMed:29487133, ECO:0000269|PubMed:34957824, ECO:0007744|PDB:1HDO, ECO:0007744|PDB:1HE2, ECO:0007744|PDB:1HE3, ECO:0007744|PDB:1HE4, ECO:0007744|PDB:1HE5, ECO:0007744|PDB:5OOG, ECO:0007744|PDB:5OOH, ECO:0007744|PDB:7ER6, ECO:0007744|PDB:7ER7, ECO:0007744|PDB:7ER8, ECO:0007744|PDB:7ER9, ECO:0007744|PDB:7ERA, ECO:0007744|PDB:7ERB, ECO:0007744|PDB:7ERC, ECO:0007744|PDB:7ERD, ECO:0007744|PDB:7ERE |
Chain | Residue | Details |
A | THR15 | |
A | GLY155 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:34957824, ECO:0007744|PDB:7ER6, ECO:0007744|PDB:7ER9, ECO:0007744|PDB:7ERA, ECO:0007744|PDB:7ERB, ECO:0007744|PDB:7ERD, ECO:0007744|PDB:7ERE |
Chain | Residue | Details |
A | ARG39 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:29487133, ECO:0000269|PubMed:32246827, ECO:0000269|PubMed:34957824, ECO:0007744|PDB:5OOH, ECO:0007744|PDB:6OPL, ECO:0007744|PDB:7ER6, ECO:0007744|PDB:7ER7, ECO:0007744|PDB:7ER8, ECO:0007744|PDB:7ER9, ECO:0007744|PDB:7ERA, ECO:0007744|PDB:7ERB, ECO:0007744|PDB:7ERC, ECO:0007744|PDB:7ERE |
Chain | Residue | Details |
A | LEU40 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11224564, ECO:0000269|PubMed:32246827, ECO:0000269|PubMed:34957824, ECO:0007744|PDB:1HDO, ECO:0007744|PDB:1HE2, ECO:0007744|PDB:1HE3, ECO:0007744|PDB:1HE4, ECO:0007744|PDB:1HE5, ECO:0007744|PDB:6OPL, ECO:0007744|PDB:7ER6, ECO:0007744|PDB:7ER7, ECO:0007744|PDB:7ER8, ECO:0007744|PDB:7ER9, ECO:0007744|PDB:7ERA, ECO:0007744|PDB:7ERB, ECO:0007744|PDB:7ERC, ECO:0007744|PDB:7ERD, ECO:0007744|PDB:7ERE |
Chain | Residue | Details |
A | GLY76 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11224564, ECO:0000269|PubMed:29487133, ECO:0000269|PubMed:32246827, ECO:0000269|PubMed:34957824, ECO:0007744|PDB:1HDO, ECO:0007744|PDB:1HE2, ECO:0007744|PDB:1HE3, ECO:0007744|PDB:1HE4, ECO:0007744|PDB:1HE5, ECO:0007744|PDB:5OOH, ECO:0007744|PDB:6OPL, ECO:0007744|PDB:7ER6, ECO:0007744|PDB:7ER7, ECO:0007744|PDB:7ER8, ECO:0007744|PDB:7ER9, ECO:0007744|PDB:7ERA, ECO:0007744|PDB:7ERB, ECO:0007744|PDB:7ERC, ECO:0007744|PDB:7ERD, ECO:0007744|PDB:7ERE |
Chain | Residue | Details |
A | THR110 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11224564, ECO:0000269|PubMed:29487133, ECO:0000269|PubMed:32246827, ECO:0000269|PubMed:34957824, ECO:0007744|PDB:1HE3, ECO:0007744|PDB:5OOG, ECO:0007744|PDB:5OOH, ECO:0007744|PDB:6OPL, ECO:0007744|PDB:7ER8, ECO:0007744|PDB:7ER9, ECO:0007744|PDB:7ERB, ECO:0007744|PDB:7ERC |
Chain | Residue | Details |
A | ILE133 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:32246827, ECO:0000269|PubMed:34957824, ECO:0007744|PDB:6OPL, ECO:0007744|PDB:7ERB, ECO:0007744|PDB:7ERD |
Chain | Residue | Details |
A | ILE154 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | GLU43 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | PRO83 |