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1HAK

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLACENTAL ANNEXIN V COMPLEXED WITH K-201 AS A CALCIUM CHANNEL ACTIVITY INHIBITOR

Functional Information from GO Data
ChainGOidnamespacecontents
A0001786molecular_functionphosphatidylserine binding
A0004859molecular_functionphospholipase inhibitor activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005544molecular_functioncalcium-dependent phospholipid binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0007165biological_processsignal transduction
A0007596biological_processblood coagulation
A0009897cellular_componentexternal side of plasma membrane
A0012506cellular_componentvesicle membrane
A0016020cellular_componentmembrane
A0042383cellular_componentsarcolemma
A0043066biological_processnegative regulation of apoptotic process
A0050819biological_processnegative regulation of coagulation
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0072563cellular_componentendothelial microparticle
B0001786molecular_functionphosphatidylserine binding
B0004859molecular_functionphospholipase inhibitor activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005544molecular_functioncalcium-dependent phospholipid binding
B0005576cellular_componentextracellular region
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005925cellular_componentfocal adhesion
B0007165biological_processsignal transduction
B0007596biological_processblood coagulation
B0009897cellular_componentexternal side of plasma membrane
B0012506cellular_componentvesicle membrane
B0016020cellular_componentmembrane
B0042383cellular_componentsarcolemma
B0043066biological_processnegative regulation of apoptotic process
B0050819biological_processnegative regulation of coagulation
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0072563cellular_componentendothelial microparticle
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE K21 B 901
ChainResidue
BLEU5
BILE247
BARG276
BILE279
BTHR118
BPRO119
BGLU121
BARG161
BVAL203
BARG207
BSER243
BILE244

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE K21 A 901
ChainResidue
ALEU5
ATHR118
APRO119
AARG161
AVAL203
AARG207
ASER243
AILE244

Functional Information from PROSITE/UniProt
site_idPS00223
Number of Residues53
DetailsANNEXIN_1 Annexin repeat signature. GTdeesiltlLtsRsnaQrqEisaaFktlfgrdLlddLkseltGkfeklIvaL
ChainResidueDetails
BGLY32-LEU84
BGLY104-LEU156
BGLY188-VAL240
BGLY263-LEU315

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330
ChainResidueDetails
BGLN3
AGLN3

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P48036
ChainResidueDetails
BILE38
AILE38

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BSER71
BPHE77
BLEU80
BHIS98
ASER71
APHE77
ALEU80
AHIS98

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:16916647
ChainResidueDetails
BGLY102
AGLY102

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P48036
ChainResidueDetails
BASN291
AASN291

site_idSWS_FT_FI6
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
ChainResidueDetails
BGLY30
AGLY30

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PDB entries from 2024-10-30

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