1H9D
Aml1/cbf-beta/dna complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0003700 | molecular_function | DNA-binding transcription factor activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0003713 | molecular_function | transcription coactivator activity |
B | 0005634 | cellular_component | nucleus |
C | 0003677 | molecular_function | DNA binding |
C | 0003700 | molecular_function | DNA-binding transcription factor activity |
C | 0005524 | molecular_function | ATP binding |
C | 0005634 | cellular_component | nucleus |
C | 0006355 | biological_process | regulation of DNA-templated transcription |
D | 0003713 | molecular_function | transcription coactivator activity |
D | 0005634 | cellular_component | nucleus |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: |
Chain | Residue | Details |
A | ASN112 | |
A | ARG139 | |
A | VAL170 | |
C | ASN112 | |
C | GLU116 | |
C | ARG139 | |
C | VAL170 | |
A | GLU116 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | SITE: Breakpoint for translocation to form AML1-EMV-1 (or AML1-EAP) in CML and T-MDS, to form AML1-MTG8 (ETO) in AML-M2, to form AML1-CBFA2T3 in therapy-related myeloid malignancies, to form AML1-MECOM in CML and to form type I MACROD1-RUNX1 fusion protein |
Chain | Residue | Details |
A | ARG177 | |
C | ARG177 |