1H7N

SCHIFF-BASE COMPLEX OF YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE WITH LAEVULINIC ACID AT 1.6 A RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004655	molecular_function	porphobilinogen synthase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006782	biological_process	protoporphyrinogen IX biosynthetic process
A	0006783	biological_process	heme biosynthetic process
A	0008270	molecular_function	zinc ion binding
A	0016829	molecular_function	lyase activity
A	0033014	biological_process	tetrapyrrole biosynthetic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1342

Chain	Residue
A	CYS133
A	CYS135
A	CYS143
A	HOH2382

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SHF A1341

Chain	Residue
A	TYR287
A	VAL289
A	SER290
A	TYR329
A	PHE89
A	LYS210
A	TYR216
A	PHE219
A	LYS263

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Functional Information from PROSITE/UniProt

site_id	PS00169
Number of Residues	13
Details	D_ALA_DEHYDRATASE Delta-aminolevulinic acid dehydratase active site. GaDgIIVKPStfY

Chain	Residue	Details
A	GLY256-TYR268

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Schiff-base intermediate with substrate

Chain	Residue	Details
A	LYS210
A	LYS263

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site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING:

Chain	Residue	Details
A	CYS133
A	CYS135
A	CYS143
A	ARG220
A	ARG232
A	SER290
A	TYR329

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	SER254

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1h7o

Chain	Residue	Details
A	SER179
A	ASP131
A	LYS263
A	LYS210

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