1H74
CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH ILE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004413 | molecular_function | homoserine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006566 | biological_process | threonine metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004413 | molecular_function | homoserine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006566 | biological_process | threonine metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004413 | molecular_function | homoserine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006566 | biological_process | threonine metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009088 | biological_process | threonine biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016740 | molecular_function | transferase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004413 | molecular_function | homoserine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006566 | biological_process | threonine metabolic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009088 | biological_process | threonine biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 600 |
| Chain | Residue |
| B | SER98 |
| B | GLU130 |
| B | AGS400 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ILE A 500 |
| Chain | Residue |
| A | THR183 |
| A | ARG187 |
| A | ARG235 |
| A | ASN17 |
| A | PHE22 |
| A | ASP23 |
| A | HIS138 |
| A | ASP140 |
| A | ASN141 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ILE B 500 |
| Chain | Residue |
| B | ALA16 |
| B | ASN17 |
| B | ASP23 |
| B | HIS138 |
| B | ASP140 |
| B | ASN141 |
| B | ARG187 |
| B | ARG235 |
| B | SER261 |
| B | AGS400 |
| B | HOH2007 |
| B | HOH2060 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ILE C 500 |
| Chain | Residue |
| C | ALA16 |
| C | ASN17 |
| C | ASP23 |
| C | HIS138 |
| C | ASP140 |
| C | ASN141 |
| C | ARG187 |
| C | ARG235 |
| C | HOH2013 |
| C | HOH2138 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ILE D 500 |
| Chain | Residue |
| D | ASN17 |
| D | PHE22 |
| D | ASP23 |
| D | ASP140 |
| D | THR183 |
| D | ARG187 |
| D | ARG235 |
| D | AGS400 |
| D | HOH2040 |
| D | HOH2057 |
| D | HOH2106 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ADP A 400 |
| Chain | Residue |
| A | ILE55 |
| A | PRO56 |
| A | LYS61 |
| A | ASN62 |
| A | VAL63 |
| A | LYS87 |
| A | ALA91 |
| A | GLY92 |
| A | SER97 |
| A | SER98 |
| A | SER101 |
| A | SER133 |
| A | THR183 |
| A | HOH2102 |
| A | HOH2103 |
| A | HOH2104 |
| A | HOH2105 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE AGS B 400 |
| Chain | Residue |
| B | PRO56 |
| B | ASN62 |
| B | VAL63 |
| B | LYS87 |
| B | ALA91 |
| B | GLY92 |
| B | GLY94 |
| B | GLY96 |
| B | SER97 |
| B | SER98 |
| B | SER101 |
| B | SER133 |
| B | ASN141 |
| B | SER261 |
| B | ILE500 |
| B | MG600 |
| B | HOH2060 |
| B | HOH2073 |
| B | HOH2074 |
| site_id | AC8 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ADP C 400 |
| Chain | Residue |
| C | HOH2157 |
| C | ILE55 |
| C | PRO56 |
| C | LYS61 |
| C | ASN62 |
| C | VAL63 |
| C | LYS87 |
| C | ALA91 |
| C | GLY92 |
| C | SER97 |
| C | SER98 |
| C | SER101 |
| C | SER133 |
| C | THR183 |
| C | HOH2046 |
| C | HOH2153 |
| C | HOH2154 |
| C | HOH2155 |
| C | HOH2156 |
| site_id | AC9 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE AGS D 400 |
| Chain | Residue |
| D | ILE55 |
| D | PRO56 |
| D | LYS61 |
| D | ASN62 |
| D | VAL63 |
| D | LYS87 |
| D | ALA91 |
| D | GLY92 |
| D | GLY94 |
| D | LEU95 |
| D | GLY96 |
| D | SER97 |
| D | SER98 |
| D | SER101 |
| D | SER133 |
| D | ASN141 |
| D | THR183 |
| D | SER261 |
| D | ILE500 |
| D | HOH2035 |
| D | HOH2103 |
| D | HOH2104 |
| D | HOH2105 |
Functional Information from PROSITE/UniProt
| site_id | PS00627 |
| Number of Residues | 12 |
| Details | GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. VKaGsGLGSSAA |
| Chain | Residue | Details |
| A | VAL89-ALA100 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fwk |
| Chain | Residue | Details |
| A | THR183 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fwk |
| Chain | Residue | Details |
| B | THR183 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fwk |
| Chain | Residue | Details |
| C | THR183 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1fwk |
| Chain | Residue | Details |
| D | THR183 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 778 |
| Chain | Residue | Details |
| A | GLU130 | metal ligand |
| A | THR183 | electrostatic stabiliser, polar interaction |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 778 |
| Chain | Residue | Details |
| B | GLU130 | metal ligand |
| B | THR183 | electrostatic stabiliser, polar interaction |
| site_id | MCSA3 |
| Number of Residues | 2 |
| Details | M-CSA 778 |
| Chain | Residue | Details |
| C | GLU130 | metal ligand |
| C | THR183 | electrostatic stabiliser, polar interaction |
| site_id | MCSA4 |
| Number of Residues | 2 |
| Details | M-CSA 778 |
| Chain | Residue | Details |
| D | GLU130 | metal ligand |
| D | THR183 | electrostatic stabiliser, polar interaction |
