1H5T
Thymidylyltransferase complexed with Thymidylyldiphosphate-glucose
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000271 | biological_process | polysaccharide biosynthetic process |
| A | 0005829 | cellular_component | cytosol |
| A | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| A | 0009243 | biological_process | O antigen biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051289 | biological_process | protein homotetramerization |
| B | 0000271 | biological_process | polysaccharide biosynthetic process |
| B | 0005829 | cellular_component | cytosol |
| B | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| B | 0009243 | biological_process | O antigen biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051289 | biological_process | protein homotetramerization |
| C | 0000271 | biological_process | polysaccharide biosynthetic process |
| C | 0005829 | cellular_component | cytosol |
| C | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| C | 0009243 | biological_process | O antigen biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016779 | molecular_function | nucleotidyltransferase activity |
| C | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051289 | biological_process | protein homotetramerization |
| D | 0000271 | biological_process | polysaccharide biosynthetic process |
| D | 0005829 | cellular_component | cytosol |
| D | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| D | 0009243 | biological_process | O antigen biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016779 | molecular_function | nucleotidyltransferase activity |
| D | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051289 | biological_process | protein homotetramerization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D1294 |
| Chain | Residue |
| D | LYS81 |
| D | VAL82 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TYD A1292 |
| Chain | Residue |
| A | SER252 |
| A | GLU256 |
| A | ILE257 |
| A | HOH2125 |
| A | HOH2143 |
| D | GLY219 |
| D | ARG220 |
| D | GLY221 |
| A | LEU46 |
| A | TYR115 |
| A | GLY116 |
| A | HIS117 |
| A | ASP118 |
| A | PRO120 |
| A | VAL251 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE DAU A1293 |
| Chain | Residue |
| A | LEU9 |
| A | GLY11 |
| A | GLY12 |
| A | GLN83 |
| A | PRO86 |
| A | ASP87 |
| A | GLY88 |
| A | LEU109 |
| A | ASP111 |
| A | TYR146 |
| A | GLY147 |
| A | GLU162 |
| A | LYS163 |
| A | VAL173 |
| A | ARG195 |
| A | GLU197 |
| A | THR201 |
| A | HOH2090 |
| A | HOH2091 |
| A | HOH2144 |
| A | HOH2145 |
| A | HOH2146 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TYD B1292 |
| Chain | Residue |
| B | LEU46 |
| B | TYR115 |
| B | GLY116 |
| B | HIS117 |
| B | ASP118 |
| B | VAL251 |
| B | SER252 |
| B | GLU256 |
| B | ILE257 |
| B | HOH2096 |
| B | HOH2097 |
| C | GLY219 |
| C | ARG220 |
| C | GLY221 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE DAU B1293 |
| Chain | Residue |
| B | LEU9 |
| B | GLY11 |
| B | GLN83 |
| B | PRO86 |
| B | ASP87 |
| B | GLY88 |
| B | LEU109 |
| B | ASP111 |
| B | TYR146 |
| B | GLY147 |
| B | GLU162 |
| B | LYS163 |
| B | VAL173 |
| B | ARG195 |
| B | GLU197 |
| B | THR201 |
| B | HOH2058 |
| B | HOH2063 |
| B | HOH2098 |
| B | HOH2099 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TYD C1292 |
| Chain | Residue |
| B | GLY219 |
| B | ARG220 |
| B | GLY221 |
| C | LEU46 |
| C | TYR115 |
| C | GLY116 |
| C | HIS117 |
| C | ASP118 |
| C | LYS250 |
| C | VAL251 |
| C | SER252 |
| C | GLU256 |
| C | HOH2118 |
| C | HOH2119 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE DAU C1293 |
| Chain | Residue |
| C | GLY147 |
| C | GLU162 |
| C | LYS163 |
| C | VAL173 |
| C | ARG195 |
| C | GLU197 |
| C | THR201 |
| C | TRP224 |
| C | HOH2069 |
| C | HOH2077 |
| C | LEU9 |
| C | GLY11 |
| C | GLY12 |
| C | GLN27 |
| C | GLN83 |
| C | PRO86 |
| C | ASP87 |
| C | GLY88 |
| C | LEU89 |
| C | LEU109 |
| C | ASP111 |
| C | TYR146 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TYD D1292 |
| Chain | Residue |
| A | GLY219 |
| A | ARG220 |
| A | GLY221 |
| D | LEU46 |
| D | TYR115 |
| D | GLY116 |
| D | HIS117 |
| D | ASP118 |
| D | VAL251 |
| D | SER252 |
| D | GLU256 |
| D | ILE257 |
| D | HOH2134 |
| D | HOH2135 |
| D | HOH2136 |
| site_id | AC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE DAU D1293 |
| Chain | Residue |
| D | LEU9 |
| D | GLY11 |
| D | GLY12 |
| D | GLN27 |
| D | GLN83 |
| D | PRO86 |
| D | ASP87 |
| D | GLY88 |
| D | LEU89 |
| D | LEU109 |
| D | GLY110 |
| D | ASP111 |
| D | ASN112 |
| D | TYR146 |
| D | GLY147 |
| D | GLU162 |
| D | LYS163 |
| D | VAL173 |
| D | GLU197 |
| D | HOH2090 |
| D | HOH2137 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P61887 |
| Chain | Residue | Details |
| B | ASP111 | |
| B | ASP226 | |
| C | ASP111 | |
| C | ASP226 | |
| D | ASP111 | |
| D | ASP226 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| A | ARG16 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| C | ARG16 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| D | ARG16 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| B | ARG16 |
