Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1H5T

Thymidylyltransferase complexed with Thymidylyldiphosphate-glucose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000271	biological_process	polysaccharide biosynthetic process
A	0005829	cellular_component	cytosol
A	0008879	molecular_function	glucose-1-phosphate thymidylyltransferase activity
A	0009058	biological_process	biosynthetic process
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0009243	biological_process	O antigen biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0019305	biological_process	dTDP-rhamnose biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051289	biological_process	protein homotetramerization
B	0000271	biological_process	polysaccharide biosynthetic process
B	0005829	cellular_component	cytosol
B	0008879	molecular_function	glucose-1-phosphate thymidylyltransferase activity
B	0009058	biological_process	biosynthetic process
B	0009103	biological_process	lipopolysaccharide biosynthetic process
B	0009243	biological_process	O antigen biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0019305	biological_process	dTDP-rhamnose biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051289	biological_process	protein homotetramerization
C	0000271	biological_process	polysaccharide biosynthetic process
C	0005829	cellular_component	cytosol
C	0008879	molecular_function	glucose-1-phosphate thymidylyltransferase activity
C	0009058	biological_process	biosynthetic process
C	0009103	biological_process	lipopolysaccharide biosynthetic process
C	0009243	biological_process	O antigen biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0019305	biological_process	dTDP-rhamnose biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051289	biological_process	protein homotetramerization
D	0000271	biological_process	polysaccharide biosynthetic process
D	0005829	cellular_component	cytosol
D	0008879	molecular_function	glucose-1-phosphate thymidylyltransferase activity
D	0009058	biological_process	biosynthetic process
D	0009103	biological_process	lipopolysaccharide biosynthetic process
D	0009243	biological_process	O antigen biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0019305	biological_process	dTDP-rhamnose biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051289	biological_process	protein homotetramerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D1294

Chain	Residue
D	LYS81
D	VAL82

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TYD A1292

Chain	Residue
A	SER252
A	GLU256
A	ILE257
A	HOH2125
A	HOH2143
D	GLY219
D	ARG220
D	GLY221
A	LEU46
A	TYR115
A	GLY116
A	HIS117
A	ASP118
A	PRO120
A	VAL251

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE DAU A1293

Chain	Residue
A	LEU9
A	GLY11
A	GLY12
A	GLN83
A	PRO86
A	ASP87
A	GLY88
A	LEU109
A	ASP111
A	TYR146
A	GLY147
A	GLU162
A	LYS163
A	VAL173
A	ARG195
A	GLU197
A	THR201
A	HOH2090
A	HOH2091
A	HOH2144
A	HOH2145
A	HOH2146

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TYD B1292

Chain	Residue
B	LEU46
B	TYR115
B	GLY116
B	HIS117
B	ASP118
B	VAL251
B	SER252
B	GLU256
B	ILE257
B	HOH2096
B	HOH2097
C	GLY219
C	ARG220
C	GLY221

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE DAU B1293

Chain	Residue
B	LEU9
B	GLY11
B	GLN83
B	PRO86
B	ASP87
B	GLY88
B	LEU109
B	ASP111
B	TYR146
B	GLY147
B	GLU162
B	LYS163
B	VAL173
B	ARG195
B	GLU197
B	THR201
B	HOH2058
B	HOH2063
B	HOH2098
B	HOH2099

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TYD C1292

Chain	Residue
B	GLY219
B	ARG220
B	GLY221
C	LEU46
C	TYR115
C	GLY116
C	HIS117
C	ASP118
C	LYS250
C	VAL251
C	SER252
C	GLU256
C	HOH2118
C	HOH2119

site_id	AC7
Number of Residues	22
Details	BINDING SITE FOR RESIDUE DAU C1293

Chain	Residue
C	GLY147
C	GLU162
C	LYS163
C	VAL173
C	ARG195
C	GLU197
C	THR201
C	TRP224
C	HOH2069
C	HOH2077
C	LEU9
C	GLY11
C	GLY12
C	GLN27
C	GLN83
C	PRO86
C	ASP87
C	GLY88
C	LEU89
C	LEU109
C	ASP111
C	TYR146

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TYD D1292

Chain	Residue
A	GLY219
A	ARG220
A	GLY221
D	LEU46
D	TYR115
D	GLY116
D	HIS117
D	ASP118
D	VAL251
D	SER252
D	GLU256
D	ILE257
D	HOH2134
D	HOH2135
D	HOH2136

site_id	AC9
Number of Residues	21
Details	BINDING SITE FOR RESIDUE DAU D1293

Chain	Residue
D	LEU9
D	GLY11
D	GLY12
D	GLN27
D	GLN83
D	PRO86
D	ASP87
D	GLY88
D	LEU89
D	LEU109
D	GLY110
D	ASP111
D	ASN112
D	TYR146
D	GLY147
D	GLU162
D	LYS163
D	VAL173
D	GLU197
D	HOH2090
D	HOH2137

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P61887","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1hv9

Chain	Residue	Details
A	ARG16

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1hv9

Chain	Residue	Details
C	ARG16

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1hv9

Chain	Residue	Details
D	ARG16

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1hv9

Chain	Residue	Details
B	ARG16

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)