1H4W

Structure of human trypsin IV (brain trypsin)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 260

Chain	Residue
A	GLU70
A	ASN72
A	VAL75
A	GLU77
A	GLU80
A	HOH2035

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BEN A 250

Chain	Residue
A	GLN192
A	SER195
A	GLY216
A	GLY219
A	GLY226
A	ASP189
A	SER190
A	CYS191

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
A	VAL53-CYS58

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27810896","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11827488","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25301953","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27810896","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1H4W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L3T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U30","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11827488","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25301953","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27810896","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1H4W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L3T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U30","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11827488","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25301953","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27810896","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1H4W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L3T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Required for specificity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Sulfotyrosine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	HIS57

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	SER195
A	GLY196

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	SER195
A	ARG193

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	SER195
A	HIS57

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	SER195
A	HIS57
A	GLY196

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP102
A	SER195
A	ARG193
A	HIS57

---