1H4T
Prolyl-tRNA synthetase from Thermus thermophilus complexed with L-proline
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004827 | molecular_function | proline-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004827 | molecular_function | proline-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004827 | molecular_function | proline-tRNA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006412 | biological_process | translation |
| C | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| C | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004827 | molecular_function | proline-tRNA ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006412 | biological_process | translation |
| D | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| D | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 490 |
| Chain | Residue |
| A | CYS427 |
| A | CYS432 |
| A | CYS458 |
| A | CYS461 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 490 |
| Chain | Residue |
| B | CYS427 |
| B | CYS432 |
| B | CYS458 |
| B | CYS461 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 490 |
| Chain | Residue |
| C | CYS432 |
| C | CYS458 |
| C | CYS461 |
| C | CYS427 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 490 |
| Chain | Residue |
| D | CYS427 |
| D | CYS432 |
| D | CYS458 |
| D | CYS461 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PRO A1478 |
| Chain | Residue |
| A | THR111 |
| A | GLU113 |
| A | ARG142 |
| A | TRP158 |
| A | GLU160 |
| A | PHE205 |
| A | HIS230 |
| A | SER258 |
| A | TRP259 |
| A | GLY260 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PRO B1478 |
| Chain | Residue |
| B | THR111 |
| B | GLU113 |
| B | ARG142 |
| B | TRP158 |
| B | GLU160 |
| B | PHE205 |
| B | THR228 |
| B | HIS230 |
| B | SER258 |
| B | TRP259 |
| B | GLY260 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PRO C1478 |
| Chain | Residue |
| C | THR111 |
| C | GLU113 |
| C | ARG142 |
| C | TRP158 |
| C | GLU160 |
| C | PHE205 |
| C | THR228 |
| C | HIS230 |
| C | SER258 |
| C | TRP259 |
| C | GLY260 |
| C | HOH2112 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PRO D1478 |
| Chain | Residue |
| D | THR111 |
| D | GLU113 |
| D | ARG142 |
| D | TRP158 |
| D | GLU160 |
| D | PHE205 |
| D | THR228 |
| D | HIS230 |
| D | SER258 |
| D | TRP259 |
| D | GLY260 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11399074 |
| Chain | Residue | Details |
| A | THR111 | |
| C | GLU113 | |
| C | ARG142 | |
| C | HIS230 | |
| D | THR111 | |
| D | GLU113 | |
| D | ARG142 | |
| D | HIS230 | |
| A | GLU113 | |
| A | ARG142 | |
| A | HIS230 | |
| B | THR111 | |
| B | GLU113 | |
| B | ARG142 | |
| B | HIS230 | |
| C | THR111 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:11399074 |
| Chain | Residue | Details |
| A | THR153 | |
| B | ARG264 | |
| C | THR153 | |
| C | GLN225 | |
| C | THR228 | |
| C | SER262 | |
| C | ARG264 | |
| D | THR153 | |
| D | GLN225 | |
| D | THR228 | |
| D | SER262 | |
| A | GLN225 | |
| D | ARG264 | |
| A | THR228 | |
| A | SER262 | |
| A | ARG264 | |
| B | THR153 | |
| B | GLN225 | |
| B | THR228 | |
| B | SER262 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10970866, ECO:0000269|PubMed:11399074 |
| Chain | Residue | Details |
| A | CYS427 | |
| C | CYS432 | |
| C | CYS458 | |
| C | CYS461 | |
| D | CYS427 | |
| D | CYS432 | |
| D | CYS458 | |
| D | CYS461 | |
| A | CYS432 | |
| A | CYS458 | |
| A | CYS461 | |
| B | CYS427 | |
| B | CYS432 | |
| B | CYS458 | |
| B | CYS461 | |
| C | CYS427 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qf6 |
| Chain | Residue | Details |
| A | ARG142 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qf6 |
| Chain | Residue | Details |
| B | ARG142 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qf6 |
| Chain | Residue | Details |
| C | ARG142 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1qf6 |
| Chain | Residue | Details |
| D | ARG142 |
