1H4O
Monoclinic form of human peroxiredoxin 5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008379 | molecular_function | thioredoxin peroxidase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0008379 | molecular_function | thioredoxin peroxidase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| C | 0008379 | molecular_function | thioredoxin peroxidase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0034599 | biological_process | cellular response to oxidative stress |
| D | 0008379 | molecular_function | thioredoxin peroxidase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0034599 | biological_process | cellular response to oxidative stress |
| E | 0008379 | molecular_function | thioredoxin peroxidase activity |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0034599 | biological_process | cellular response to oxidative stress |
| F | 0008379 | molecular_function | thioredoxin peroxidase activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0034599 | biological_process | cellular response to oxidative stress |
| G | 0008379 | molecular_function | thioredoxin peroxidase activity |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0034599 | biological_process | cellular response to oxidative stress |
| H | 0008379 | molecular_function | thioredoxin peroxidase activity |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0034599 | biological_process | cellular response to oxidative stress |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BEZ A 1162 |
| Chain | Residue |
| A | PRO40 |
| A | THR44 |
| A | PRO45 |
| A | GLY46 |
| A | CYS47 |
| A | ARG127 |
| B | ALA64 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BEZ B 1162 |
| Chain | Residue |
| B | PRO45 |
| B | GLY46 |
| B | CYS47 |
| B | ARG127 |
| C | ALA64 |
| C | HOH2092 |
| B | PRO40 |
| B | THR44 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BEZ C 1162 |
| Chain | Residue |
| C | THR44 |
| C | PRO45 |
| C | GLY46 |
| C | CYS47 |
| C | ARG127 |
| C | HOH2188 |
| D | LYS63 |
| D | ALA64 |
| D | GLY66 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BEZ D 1162 |
| Chain | Residue |
| D | PRO40 |
| D | THR44 |
| D | PRO45 |
| D | GLY46 |
| D | CYS47 |
| D | ARG127 |
| D | HOH2184 |
| E | ALA64 |
| E | GLY66 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BEZ E 1162 |
| Chain | Residue |
| E | THR44 |
| E | PRO45 |
| E | GLY46 |
| E | CYS47 |
| E | ARG127 |
| E | HOH2128 |
| F | LYS63 |
| F | ALA64 |
| F | GLY66 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BEZ F 1162 |
| Chain | Residue |
| F | THR44 |
| F | PRO45 |
| F | GLY46 |
| F | CYS47 |
| F | ARG127 |
| F | HOH2160 |
| G | LYS63 |
| G | ALA64 |
| G | GLY66 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BEZ G 1162 |
| Chain | Residue |
| G | THR44 |
| G | PRO45 |
| G | GLY46 |
| G | CYS47 |
| G | PHE120 |
| G | ARG127 |
| G | HOH2139 |
| H | ALA64 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BEZ H 1162 |
| Chain | Residue |
| A | ALA64 |
| A | HOH2090 |
| H | PRO40 |
| H | THR44 |
| H | PRO45 |
| H | GLY46 |
| H | CYS47 |
| H | ARG127 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305|PubMed:10751410, ECO:0000305|PubMed:20643143 |
| Chain | Residue | Details |
| A | CYS47 | |
| B | CYS47 | |
| C | CYS47 | |
| D | CYS47 | |
| E | CYS47 | |
| F | CYS47 | |
| G | CYS47 | |
| H | CYS47 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P99029 |
| Chain | Residue | Details |
| A | LYS22 | |
| B | LYS22 | |
| C | LYS22 | |
| D | LYS22 | |
| E | LYS22 | |
| F | LYS22 | |
| G | LYS22 | |
| H | LYS22 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99029 |
| Chain | Residue | Details |
| A | LYS30 | |
| B | LYS30 | |
| C | LYS30 | |
| D | LYS30 | |
| E | LYS30 | |
| F | LYS30 | |
| G | LYS30 | |
| H | LYS30 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P99029 |
| Chain | Residue | Details |
| A | LYS63 | |
| B | LYS63 | |
| C | LYS63 | |
| D | LYS63 | |
| E | LYS63 | |
| F | LYS63 | |
| G | LYS63 | |
| H | LYS63 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9R063 |
| Chain | Residue | Details |
| A | SER118 | |
| B | SER118 | |
| C | SER118 | |
| D | SER118 | |
| E | SER118 | |
| F | SER118 | |
| G | SER118 | |
| H | SER118 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P99029 |
| Chain | Residue | Details |
| A | SER129 | |
| B | SER129 | |
| C | SER129 | |
| D | SER129 | |
| E | SER129 | |
| F | SER129 | |
| G | SER129 | |
| H | SER129 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:31740833 |
| Chain | Residue | Details |
| A | CYS47 | |
| B | CYS47 | |
| C | CYS47 | |
| D | CYS47 | |
| E | CYS47 | |
| F | CYS47 | |
| G | CYS47 | |
| H | CYS47 |
