1H16
Pyruvate Formate-Lyase (E.coli) in complex with Pyruvate and CoA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006006 | biological_process | glucose metabolic process |
A | 0008861 | molecular_function | formate C-acetyltransferase activity |
A | 0016020 | cellular_component | membrane |
A | 0016740 | molecular_function | transferase activity |
A | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 9001 |
Chain | Residue |
A | ALA652 |
A | LEU654 |
A | GLU700 |
A | GLY701 |
A | HOH3157 |
A | HOH3160 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA A 9002 |
Chain | Residue |
A | HOH2595 |
A | HOH2920 |
A | GLU214 |
A | GLN215 |
A | ARG218 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA A 9003 |
Chain | Residue |
A | THR80 |
A | ILE81 |
A | SER268 |
A | HOH2138 |
A | HOH2140 |
A | HOH2327 |
A | HOH2330 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA A 9004 |
Chain | Residue |
A | HOH2624 |
A | HOH3136 |
A | PG49013 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA A 9005 |
Chain | Residue |
A | GLN589 |
A | PRO599 |
A | HOH2558 |
A | HOH3027 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA A 9006 |
Chain | Residue |
A | LYS62 |
A | HOH2101 |
A | HOH2258 |
A | HOH3192 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 9007 |
Chain | Residue |
A | PHE112 |
A | HOH2138 |
A | HOH2689 |
A | HOH2933 |
A | HOH3256 |
A | HOH3257 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG A 9008 |
Chain | Residue |
A | COA1000 |
A | HOH2498 |
A | HOH3250 |
site_id | AC9 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE COA A 1000 |
Chain | Residue |
A | LYS116 |
A | MET117 |
A | ASN145 |
A | GLN146 |
A | PHE149 |
A | ASP150 |
A | TYR152 |
A | ARG160 |
A | LYS161 |
A | PHE200 |
A | HIS227 |
A | HOH2498 |
A | HOH2744 |
A | HOH3237 |
A | HOH3238 |
A | HOH3239 |
A | HOH3240 |
A | HOH3241 |
A | HOH3242 |
A | HOH3244 |
A | HOH3245 |
A | HOH3246 |
A | HOH3247 |
A | HOH3248 |
A | HOH3249 |
A | HOH3251 |
A | MG9008 |
site_id | BC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PYR A 1001 |
Chain | Residue |
A | ARG176 |
A | ALA273 |
A | CYS418 |
A | PHE432 |
A | ARG435 |
A | LEU604 |
A | ILE606 |
A | HOH3252 |
site_id | BC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE DTL A 9009 |
Chain | Residue |
A | THR138 |
A | GLU139 |
A | LYS142 |
A | GLU225 |
A | ARG228 |
A | GLN232 |
A | HOH2454 |
A | HOH2455 |
A | HOH3253 |
A | HOH3254 |
A | HOH3255 |
A | HOH3256 |
A | HOH3257 |
site_id | BC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE DTL A 9010 |
Chain | Residue |
A | HIS68 |
A | PRO70 |
A | TYR125 |
A | ASP324 |
A | ASP330 |
A | SER741 |
A | HOH2297 |
A | HOH3259 |
A | HOH3260 |
A | HOH3261 |
A | HOH3262 |
site_id | BC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE PG4 A 9011 |
Chain | Residue |
A | GLU40 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 A 9012 |
Chain | Residue |
A | GLN199 |
A | SER202 |
A | ARG516 |
A | ASP517 |
A | HOH3266 |
A | ALA198 |
site_id | BC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PG4 A 9013 |
Chain | Residue |
A | LEU648 |
A | THR649 |
A | LEU688 |
A | GLY691 |
A | TYR692 |
A | HOH3267 |
A | NA9004 |
Functional Information from PROSITE/UniProt
site_id | PS00850 |
Number of Residues | 9 |
Details | GLY_RADICAL_1 Glycine radical domain signature. TiRVSGYAV |
Chain | Residue | Details |
A | THR729-VAL737 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: S-acetylcysteine intermediate => ECO:0000269|PubMed:1310545 |
Chain | Residue | Details |
A | CYS419 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Cysteine radical intermediate => ECO:0000269|PubMed:1310545 |
Chain | Residue | Details |
A | VAL420 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:21151122 |
Chain | Residue | Details |
A | LEU63 | |
A | MET117 | |
A | ASP195 | |
A | LEU454 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: N6-succinyllysine => ECO:0000269|PubMed:21151122 |
Chain | Residue | Details |
A | ARG107 | |
A | ALA124 | |
A | GLY467 | |
A | LEU654 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
Chain | Residue | Details |
A | TYR541 | |
A | LEU591 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Glycine radical => ECO:0000269|PubMed:1310545 |
Chain | Residue | Details |
A | TYR735 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 30 |
Chain | Residue | Details |
A | ALA334 | hydrogen bond donor, radical stabiliser |
A | CYS419 | covalently attached, hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor, leaving group (radical), radical combinant |
A | VAL420 | hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor, hydrogen radical relay |
A | TYR735 | hydrogen bond acceptor, hydrogen bond donor, hydrogen radical acceptor, hydrogen radical donor |