1GZ5
Trehalose-6-phosphate synthase. OtsA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003825 | molecular_function | alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity |
| A | 0005992 | biological_process | trehalose biosynthetic process |
| A | 0006950 | biological_process | response to stress |
| A | 0006970 | biological_process | response to osmotic stress |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016758 | molecular_function | hexosyltransferase activity |
| A | 0070415 | biological_process | trehalose metabolism in response to cold stress |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003825 | molecular_function | alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity |
| B | 0005992 | biological_process | trehalose biosynthetic process |
| B | 0006950 | biological_process | response to stress |
| B | 0006970 | biological_process | response to osmotic stress |
| B | 0006974 | biological_process | DNA damage response |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016758 | molecular_function | hexosyltransferase activity |
| B | 0070415 | biological_process | trehalose metabolism in response to cold stress |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003825 | molecular_function | alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity |
| C | 0005992 | biological_process | trehalose biosynthetic process |
| C | 0006950 | biological_process | response to stress |
| C | 0006970 | biological_process | response to osmotic stress |
| C | 0006974 | biological_process | DNA damage response |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0016758 | molecular_function | hexosyltransferase activity |
| C | 0070415 | biological_process | trehalose metabolism in response to cold stress |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003825 | molecular_function | alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity |
| D | 0005992 | biological_process | trehalose biosynthetic process |
| D | 0006950 | biological_process | response to stress |
| D | 0006970 | biological_process | response to osmotic stress |
| D | 0006974 | biological_process | DNA damage response |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0016758 | molecular_function | hexosyltransferase activity |
| D | 0070415 | biological_process | trehalose metabolism in response to cold stress |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12498887, ECO:0000269|PubMed:20077550, ECO:0007744|PDB:1GZ5, ECO:0007744|PDB:2WTX |
| Chain | Residue | Details |
| A | ILE10 | |
| C | ASN77 | |
| C | TYR131 | |
| C | GLY301 | |
| D | ILE10 | |
| D | ASN77 | |
| D | TYR131 | |
| D | GLY301 | |
| A | ASN77 | |
| A | TYR131 | |
| A | GLY301 | |
| B | ILE10 | |
| B | ASN77 | |
| B | TYR131 | |
| B | GLY301 | |
| C | ILE10 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:12498887, ECO:0000305|PubMed:14570926, ECO:0000305|PubMed:20077550, ECO:0007744|PDB:1GZ5, ECO:0007744|PDB:2WTX |
| Chain | Residue | Details |
| A | GLY22 | |
| B | GLY22 | |
| C | GLY22 | |
| D | GLY22 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:12498887, ECO:0000305|PubMed:14570926, ECO:0000305|PubMed:20077550, ECO:0007744|PDB:1GZ5, ECO:0007744|PDB:1UQT, ECO:0007744|PDB:1UQU, ECO:0007744|PDB:2WTX |
| Chain | Residue | Details |
| A | LEU263 | |
| C | GLY268 | |
| C | ASP340 | |
| C | VAL366 | |
| D | LEU263 | |
| D | GLY268 | |
| D | ASP340 | |
| D | VAL366 | |
| A | GLY268 | |
| A | ASP340 | |
| A | VAL366 | |
| B | LEU263 | |
| B | GLY268 | |
| B | ASP340 | |
| B | VAL366 | |
| C | LEU263 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | SITE: Involved in alpha anomer selectivity => ECO:0000305|PubMed:12498887 |
| Chain | Residue | Details |
| A | PRO86 | |
| A | PRO156 | |
| B | PRO86 | |
| B | PRO156 | |
| C | PRO86 | |
| C | PRO156 | |
| D | PRO86 | |
| D | PRO156 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1uqt |
| Chain | Residue | Details |
| A | ASP361 | |
| A | HIS154 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1uqt |
| Chain | Residue | Details |
| B | ASP361 | |
| B | HIS154 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1uqt |
| Chain | Residue | Details |
| C | ASP361 | |
| C | HIS154 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1uqt |
| Chain | Residue | Details |
| D | ASP361 | |
| D | HIS154 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 622 |
| Chain | Residue | Details |
| A | ILE155 | electrostatic stabiliser |
| A | GLY362 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 622 |
| Chain | Residue | Details |
| B | ILE155 | electrostatic stabiliser |
| B | GLY362 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 2 |
| Details | M-CSA 622 |
| Chain | Residue | Details |
| C | ILE155 | electrostatic stabiliser |
| C | GLY362 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 2 |
| Details | M-CSA 622 |
| Chain | Residue | Details |
| D | ILE155 | electrostatic stabiliser |
| D | GLY362 | electrostatic stabiliser |
