1GX5

Hepatitis C Virus RNA Polymerase in Complex with GTP and Manganese

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 1533

Chain	Residue
A	ASP220
A	THR221
A	ASP318
A	GTP1531
A	HOH2373
A	HOH2649

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 1534

Chain	Residue
A	HOH2650
A	HOH2651
A	HOH2652
A	ASP318
A	ASP319
A	GTP1531

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MN A 1535

Chain	Residue
A	GTP1532

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site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GTP A 1531

Chain	Residue
A	ARG48
A	THR221
A	ARG222
A	CYS223
A	PHE224
A	ASP318
A	MN1533
A	MN1534
A	HOH2097
A	HOH2373
A	HOH2641
A	HOH2642
A	HOH2651
A	HOH2652

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GTP A 1532

Chain	Residue
A	ARG32
A	PRO495
A	PRO496
A	VAL499
A	HIS502
A	ARG503
A	ARG505
A	MN1535
A	HOH2644
A	HOH2645
A	HOH2646

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10557268","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11884572","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"UniProtKB","id":"P26662","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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