1GX1
Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005515 | molecular_function | protein binding |
A | 0006744 | biological_process | ubiquinone biosynthetic process |
A | 0008270 | molecular_function | zinc ion binding |
A | 0008299 | biological_process | isoprenoid biosynthetic process |
A | 0008685 | molecular_function | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity |
A | 0016114 | biological_process | terpenoid biosynthetic process |
A | 0016829 | molecular_function | lyase activity |
A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
A | 0030145 | molecular_function | manganese ion binding |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
B | 0005515 | molecular_function | protein binding |
B | 0006744 | biological_process | ubiquinone biosynthetic process |
B | 0008270 | molecular_function | zinc ion binding |
B | 0008299 | biological_process | isoprenoid biosynthetic process |
B | 0008685 | molecular_function | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity |
B | 0016114 | biological_process | terpenoid biosynthetic process |
B | 0016829 | molecular_function | lyase activity |
B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
B | 0030145 | molecular_function | manganese ion binding |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
C | 0005515 | molecular_function | protein binding |
C | 0006744 | biological_process | ubiquinone biosynthetic process |
C | 0008270 | molecular_function | zinc ion binding |
C | 0008299 | biological_process | isoprenoid biosynthetic process |
C | 0008685 | molecular_function | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity |
C | 0016114 | biological_process | terpenoid biosynthetic process |
C | 0016829 | molecular_function | lyase activity |
C | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
C | 0030145 | molecular_function | manganese ion binding |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A1157 |
Chain | Residue |
A | ASP8 |
A | HIS10 |
A | HIS42 |
B | CDP1157 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN A1159 |
Chain | Residue |
A | GLU135 |
A | CDP1158 |
A | HOH2090 |
A | HOH2091 |
A | HOH2092 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN B1158 |
Chain | Residue |
B | GLU135 |
B | CDP1157 |
B | HOH2100 |
B | HOH2101 |
B | HOH2102 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B1159 |
Chain | Residue |
B | ASP8 |
B | HIS10 |
B | HIS42 |
B | CDP1160 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN B1161 |
Chain | Residue |
B | CDP1160 |
B | HOH2104 |
B | HOH2105 |
C | GLU135 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B1162 |
Chain | Residue |
A | GLY138 |
A | ARG142 |
B | GLY138 |
B | ARG142 |
C | GLY138 |
C | ARG142 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C1157 |
Chain | Residue |
A | CDP1158 |
C | ASP8 |
C | HIS10 |
C | HIS42 |
site_id | AC8 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE CDP A1158 |
Chain | Residue |
A | ALA100 |
A | PRO103 |
A | LYS104 |
A | MSE105 |
A | LEU106 |
A | ALA131 |
A | THR132 |
A | THR133 |
A | GLU135 |
A | MN1159 |
A | HOH2077 |
A | HOH2088 |
A | HOH2089 |
A | HOH2091 |
A | HOH2092 |
C | ASP8 |
C | HIS10 |
C | HIS42 |
C | ASP56 |
C | GLY58 |
C | ZN1157 |
site_id | AC9 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE CDP B1157 |
Chain | Residue |
A | ASP8 |
A | HIS10 |
A | HIS42 |
A | ASP56 |
A | GLY58 |
A | ZN1157 |
A | HOH2031 |
B | ALA100 |
B | PRO103 |
B | LYS104 |
B | MSE105 |
B | LEU106 |
B | ALA131 |
B | THR132 |
B | THR133 |
B | GLU135 |
B | MN1158 |
B | HOH2087 |
B | HOH2098 |
B | HOH2099 |
B | HOH2100 |
B | HOH2102 |
site_id | BC1 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE CDP B1160 |
Chain | Residue |
B | ASP8 |
B | HIS10 |
B | HIS42 |
B | ASP56 |
B | GLY58 |
B | ZN1159 |
B | MN1161 |
B | HOH2037 |
B | HOH2103 |
B | HOH2104 |
C | ALA100 |
C | PRO103 |
C | LYS104 |
C | MSE105 |
C | LEU106 |
C | ALA131 |
C | THR132 |
C | THR133 |
C | GLU135 |
C | HOH2093 |
Functional Information from PROSITE/UniProt
site_id | PS01350 |
Number of Residues | 16 |
Details | ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDGDVAlHAltDAllG |
Chain | Residue | Details |
A | SER35-GLY50 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 9 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11786530, ECO:0000269|PubMed:11829504, ECO:0000269|PubMed:11997478, ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0000269|PubMed:16511114, ECO:0000269|PubMed:19320487, ECO:0007744|PDB:1GX1, ECO:0007744|PDB:1H47, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1JY8, ECO:0007744|PDB:1U3L, ECO:0007744|PDB:1U3P, ECO:0007744|PDB:1U40, ECO:0007744|PDB:1YQN, ECO:0007744|PDB:2AMT, ECO:0007744|PDB:2GZL, ECO:0007744|PDB:3ELC, ECO:0007744|PDB:3EOR, ECO:0007744|PDB:3ERN, ECO:0007744|PDB:3ESJ, ECO:0007744|PDB:3FBA |
Chain | Residue | Details |
A | ASP8 | |
A | HIS10 | |
A | HIS42 | |
B | ASP8 | |
B | HIS10 | |
B | HIS42 | |
C | ASP8 | |
C | HIS10 | |
C | HIS42 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11786530, ECO:0000269|PubMed:11829504, ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1KNJ, ECO:0007744|PDB:1U43, ECO:0007744|PDB:2AMT |
Chain | Residue | Details |
A | HIS34 | |
B | HIS34 | |
C | HIS34 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11829504, ECO:0000269|PubMed:11997478, ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0000269|PubMed:16511114, ECO:0000269|PubMed:19320487, ECO:0000312|PDB:1U43, ECO:0007744|PDB:1GX1, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1U3L, ECO:0007744|PDB:1U3P, ECO:0007744|PDB:1YQN, ECO:0007744|PDB:2AMT, ECO:0007744|PDB:2GZL, ECO:0007744|PDB:3ERN |
Chain | Residue | Details |
A | ASP56 | |
B | ASP56 | |
C | ASP56 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11829504, ECO:0000269|PubMed:15608374, ECO:0000312|PDB:1JY8, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1U3P, ECO:0007744|PDB:1U40 |
Chain | Residue | Details |
A | PHE61 | |
B | PHE61 | |
C | PHE61 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11786530, ECO:0000269|PubMed:11997478, ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0000269|PubMed:19320487, ECO:0007744|PDB:1GX1, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1KNJ, ECO:0007744|PDB:1U3L, ECO:0007744|PDB:1YQN, ECO:0007744|PDB:2AMT, ECO:0007744|PDB:3ELC, ECO:0007744|PDB:3EOR, ECO:0007744|PDB:3ERN, ECO:0007744|PDB:3ESJ, ECO:0007744|PDB:3FBA |
Chain | Residue | Details |
A | ALA100 | |
B | ALA100 | |
C | ALA100 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11997478, ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0000269|PubMed:19320487, ECO:0007744|PDB:1GX1, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1U3L, ECO:0007744|PDB:1YQN, ECO:0007744|PDB:2AMT, ECO:0007744|PDB:3ERN |
Chain | Residue | Details |
A | THR132 | |
B | THR132 | |
C | THR132 |
site_id | SWS_FT_FI7 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0000269|PubMed:16511114, ECO:0000269|PubMed:19320487, ECO:0007744|PDB:1H48, ECO:0007744|PDB:1YQN, ECO:0007744|PDB:2AMT, ECO:0007744|PDB:3ELC, ECO:0007744|PDB:3ERN |
Chain | Residue | Details |
A | PHE139 | |
B | PHE139 | |
C | PHE139 |
site_id | SWS_FT_FI8 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15608374, ECO:0000269|PubMed:16392111, ECO:0000269|PubMed:19320487, ECO:0000312|PDB:3ELC, ECO:0007744|PDB:1H48, ECO:0007744|PDB:2AMT, ECO:0007744|PDB:2GZL, ECO:0007744|PDB:3EOR, ECO:0007744|PDB:3ERN, ECO:0007744|PDB:3ESJ, ECO:0007744|PDB:3FBA |
Chain | Residue | Details |
A | ARG142 | |
B | ARG142 | |
C | ARG142 |
site_id | SWS_FT_FI9 |
Number of Residues | 6 |
Details | SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00107, ECO:0000305|PubMed:11786530 |
Chain | Residue | Details |
A | HIS34 | |
A | THR133 | |
B | HIS34 | |
B | THR133 | |
C | HIS34 | |
C | THR133 |