Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1GWH

Atomic resolution structure of Micrococcus Lysodeikticus catalase complexed with NADPH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004096	molecular_function	catalase activity
A	0004601	molecular_function	peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0006979	biological_process	response to oxidative stress
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0046872	molecular_function	metal ion binding
A	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ACT A 507

Chain	Residue
A	PRO60
A	HIS61
A	VAL101
A	ASN133
A	PHE138
A	PHE146
A	HEM504
A	HOH2565
A	HOH2566

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT A 508

Chain	Residue
A	VAL101
A	ASP113
A	VAL114
A	PHE139
A	PHE149
A	GLN153
A	HOH2567
A	HOH2568

site_id	AC3
Number of Residues	26
Details	BINDING SITE FOR RESIDUE HEM A 504

Chain	Residue
A	HIS47
A	ASN51
A	ARG58
A	ARG59
A	HIS61
A	ARG97
A	GLY116
A	VAL131
A	GLY132
A	ASN133
A	PRO143
A	PHE146
A	GLY201
A	SER202
A	LEU284
A	PHE319
A	MET335
A	ARG339
A	TYR343
A	GLN347
A	ARG350
A	ACT507
A	HOH2107
A	HOH2553
A	HOH2554
A	HOH2566

site_id	AC4
Number of Residues	19
Details	Binding site for residues NDP A 505 and SO4 A 506

Chain	Residue
A	TYR183
A	PRO187
A	ARG188
A	ASN198
A	TYR200
A	SER289
A	GLN290
A	ARG295
A	VAL437
A	HOH2198
A	HOH2293
A	HOH2295
A	HOH2484
A	HOH2555
A	HOH2556
A	HOH2557
A	HOH2559
A	HOH2560
A	HOH2564

site_id	AC5
Number of Residues	19
Details	Binding site for residues NDP A 505 and SO4 A 506

Chain	Residue
A	TYR183
A	PRO187
A	ARG188
A	ASN198
A	TYR200
A	SER289
A	GLN290
A	ARG295
A	VAL437
A	HOH2198
A	HOH2293
A	HOH2295
A	HOH2484
A	HOH2555
A	HOH2556
A	HOH2557
A	HOH2559
A	HOH2560
A	HOH2564

site_id	AC6
Number of Residues	19
Details	Binding site for residues NDP A 505 and SO4 A 506

Chain	Residue
A	HOH2564
A	TYR183
A	PRO187
A	ARG188
A	ASN198
A	TYR200
A	SER289
A	GLN290
A	ARG295
A	VAL437
A	HOH2198
A	HOH2293
A	HOH2295
A	HOH2484
A	HOH2555
A	HOH2556
A	HOH2557
A	HOH2559
A	HOH2560

site_id	AC7
Number of Residues	19
Details	Binding site for residues NDP A 505 and SO4 A 506

Chain	Residue
A	TYR183
A	PRO187
A	ARG188
A	ASN198
A	TYR200
A	SER289
A	GLN290
A	ARG295
A	VAL437
A	HOH2198
A	HOH2293
A	HOH2295
A	HOH2484
A	HOH2555
A	HOH2556
A	HOH2557
A	HOH2559
A	HOH2560
A	HOH2564

site_id	AC8
Number of Residues	19
Details	Binding site for residues NDP A 505 and SO4 A 506

Chain	Residue
A	TYR183
A	PRO187
A	ARG188
A	ASN198
A	TYR200
A	SER289
A	GLN290
A	ARG295
A	VAL437
A	HOH2198
A	HOH2293
A	HOH2295
A	HOH2484
A	HOH2555
A	HOH2556
A	HOH2557
A	HOH2559
A	HOH2560
A	HOH2564

site_id	AC9
Number of Residues	19
Details	Binding site for residues NDP A 505 and SO4 A 506

Chain	Residue
A	TYR183
A	PRO187
A	ARG188
A	ASN198
A	TYR200
A	SER289
A	GLN290
A	ARG295
A	VAL437
A	HOH2198
A	HOH2293
A	HOH2295
A	HOH2484
A	HOH2555
A	HOH2556
A	HOH2557
A	HOH2559
A	HOH2560
A	HOH2564

site_id	BC1
Number of Residues	19
Details	Binding site for residues NDP A 505 and SO4 A 506

Chain	Residue
A	TYR183
A	PRO187
A	ARG188
A	ASN198
A	TYR200
A	SER289
A	GLN290
A	ARG295
A	VAL437
A	HOH2198
A	HOH2293
A	HOH2295
A	HOH2484
A	HOH2555
A	HOH2556
A	HOH2557
A	HOH2559
A	HOH2560
A	HOH2564

site_id	BC2
Number of Residues	19
Details	Binding site for residues NDP A 505 and SO4 A 506

Chain	Residue
A	TYR183
A	PRO187
A	ARG188
A	ASN198
A	TYR200
A	SER289
A	GLN290
A	ARG295
A	VAL437
A	HOH2198
A	HOH2293
A	HOH2295
A	HOH2484
A	HOH2555
A	HOH2556
A	HOH2557
A	HOH2559
A	HOH2560
A	HOH2564

site_id	BC3
Number of Residues	19
Details	Binding site for residues NDP A 505 and SO4 A 506

Chain	Residue
A	TYR183
A	PRO187
A	ARG188
A	ASN198
A	TYR200
A	SER289
A	GLN290
A	ARG295
A	VAL437
A	HOH2198
A	HOH2293
A	HOH2295
A	HOH2484
A	HOH2555
A	HOH2556
A	HOH2557
A	HOH2559
A	HOH2560
A	HOH2564

site_id	BC4
Number of Residues	19
Details	Binding site for residues NDP A 505 and SO4 A 506

Chain	Residue
A	TYR183
A	PRO187
A	ARG188
A	ASN198
A	TYR200
A	SER289
A	GLN290
A	ARG295
A	VAL437
A	HOH2198
A	HOH2293
A	HOH2295
A	HOH2484
A	HOH2555
A	HOH2556
A	HOH2557
A	HOH2559
A	HOH2560
A	HOH2564

Functional Information from PROSITE/UniProt

site_id	PS00019
Number of Residues	10
Details	ACTININ_1 Actinin-type actin-binding domain signature 1. QArAFEYWKN

Chain	Residue	Details
A	GLN462-ASN471

site_id	PS00437
Number of Residues	9
Details	CATALASE_1 Catalase proximal heme-ligand signature. RAFAYhDAQ

Chain	Residue	Details
A	ARG339-GLN347

site_id	PS00438
Number of Residues	17
Details	CATALASE_2 Catalase proximal active site signature. FnRmnipERrpHakGSG

Chain	Residue	Details
A	PHE50-GLY66

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1iph

Chain	Residue	Details
A	HIS61
A	ASN133
A	SER99

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)