1GV4
Murine apoptosis-inducing factor (AIF)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE FAD A1611 |
| Chain | Residue |
| A | GLY137 |
| A | PRO172 |
| A | SER175 |
| A | LYS176 |
| A | LYS231 |
| A | VAL232 |
| A | ALA258 |
| A | THR259 |
| A | GLY260 |
| A | ARG284 |
| A | GLY436 |
| A | GLY138 |
| A | ASP437 |
| A | GLU452 |
| A | HIS453 |
| A | HIS454 |
| A | PHE481 |
| A | TRP482 |
| A | HOH2007 |
| A | HOH2016 |
| A | HOH2027 |
| A | HOH2207 |
| A | GLY139 |
| A | HOH2209 |
| A | HOH2210 |
| A | HOH2211 |
| A | HOH2212 |
| A | HOH2213 |
| A | HOH2214 |
| A | THR140 |
| A | ALA141 |
| A | VAL161 |
| A | GLU163 |
| A | ASP164 |
| A | ARG171 |
| site_id | AC2 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD B1611 |
| Chain | Residue |
| B | GLY137 |
| B | GLY138 |
| B | GLY139 |
| B | THR140 |
| B | ALA141 |
| B | VAL161 |
| B | SER162 |
| B | GLU163 |
| B | ASP164 |
| B | ARG171 |
| B | PRO172 |
| B | SER175 |
| B | LYS176 |
| B | LYS230 |
| B | LYS231 |
| B | VAL232 |
| B | ALA258 |
| B | THR259 |
| B | GLY260 |
| B | ARG284 |
| B | GLY436 |
| B | ASP437 |
| B | GLU452 |
| B | HIS453 |
| B | HIS454 |
| B | ALA457 |
| B | PHE481 |
| B | TRP482 |
| B | HOH2024 |
| B | HOH2025 |
| B | HOH2079 |
| B | HOH2137 |
| B | HOH2223 |
| B | HOH2224 |
| B | HOH2225 |
| B | HOH2226 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 698 |
| Details | Region: {"description":"FAD-dependent oxidoreductase"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 78 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 32 |
| Details | Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11967568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19447115","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GD3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GD4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11967568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19447115","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GD4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11967568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19447115","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GD3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O95831","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19447115","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GD4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19447115","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GD3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GD4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O95831","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23576753","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O95831","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"O95831","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
