Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1GSY

GLUTATHIONE S-TRANSFERASE YFYF, CLASS PI, COMPLEXED WITH GLUTATHIONE

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0002674biological_processnegative regulation of acute inflammatory response
A0004364molecular_functionglutathione transferase activity
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006693biological_processprostaglandin metabolic process
A0006749biological_processglutathione metabolic process
A0006805biological_processxenobiotic metabolic process
A0008432molecular_functionJUN kinase binding
A0009636biological_processresponse to toxic substance
A0014003biological_processoligodendrocyte development
A0015643molecular_functiontoxic substance binding
A0016740molecular_functiontransferase activity
A0019207molecular_functionkinase regulator activity
A0019901molecular_functionprotein kinase binding
A0031100biological_processanimal organ regeneration
A0031667biological_processresponse to nutrient levels
A0032355biological_processresponse to estradiol
A0032691biological_processnegative regulation of interleukin-1 beta production
A0032720biological_processnegative regulation of tumor necrosis factor production
A0032869biological_processcellular response to insulin stimulus
A0032872biological_processregulation of stress-activated MAPK cascade
A0032873biological_processnegative regulation of stress-activated MAPK cascade
A0032930biological_processpositive regulation of superoxide anion generation
A0032991cellular_componentprotein-containing complex
A0033591biological_processresponse to L-ascorbic acid
A0035726biological_processcommon myeloid progenitor cell proliferation
A0043066biological_processnegative regulation of apoptotic process
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0043200biological_processresponse to amino acid
A0043407biological_processnegative regulation of MAP kinase activity
A0043508biological_processnegative regulation of JUN kinase activity
A0045471biological_processresponse to ethanol
A0048147biological_processnegative regulation of fibroblast proliferation
A0051122biological_processhepoxilin biosynthetic process
A0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0070664biological_processnegative regulation of leukocyte proliferation
A0071222biological_processcellular response to lipopolysaccharide
A0071364biological_processcellular response to epidermal growth factor stimulus
A0071385biological_processcellular response to glucocorticoid stimulus
A0071460biological_processcellular response to cell-matrix adhesion
A0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
A0071672biological_processnegative regulation of smooth muscle cell chemotaxis
A0097159molecular_functionorganic cyclic compound binding
A1901687biological_processglutathione derivative biosynthetic process
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
A2000429biological_processnegative regulation of neutrophil aggregation
A2000469biological_processnegative regulation of peroxidase activity
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
B0000302biological_processresponse to reactive oxygen species
B0002674biological_processnegative regulation of acute inflammatory response
B0004364molecular_functionglutathione transferase activity
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006693biological_processprostaglandin metabolic process
B0006749biological_processglutathione metabolic process
B0006805biological_processxenobiotic metabolic process
B0008432molecular_functionJUN kinase binding
B0009636biological_processresponse to toxic substance
B0014003biological_processoligodendrocyte development
B0015643molecular_functiontoxic substance binding
B0016740molecular_functiontransferase activity
B0019207molecular_functionkinase regulator activity
B0019901molecular_functionprotein kinase binding
B0031100biological_processanimal organ regeneration
B0031667biological_processresponse to nutrient levels
B0032355biological_processresponse to estradiol
B0032691biological_processnegative regulation of interleukin-1 beta production
B0032720biological_processnegative regulation of tumor necrosis factor production
B0032869biological_processcellular response to insulin stimulus
B0032872biological_processregulation of stress-activated MAPK cascade
B0032873biological_processnegative regulation of stress-activated MAPK cascade
B0032930biological_processpositive regulation of superoxide anion generation
B0032991cellular_componentprotein-containing complex
B0033591biological_processresponse to L-ascorbic acid
B0035726biological_processcommon myeloid progenitor cell proliferation
B0043066biological_processnegative regulation of apoptotic process
B0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
B0043200biological_processresponse to amino acid
B0043407biological_processnegative regulation of MAP kinase activity
B0043508biological_processnegative regulation of JUN kinase activity
B0045471biological_processresponse to ethanol
B0048147biological_processnegative regulation of fibroblast proliferation
B0051122biological_processhepoxilin biosynthetic process
B0051771biological_processnegative regulation of nitric-oxide synthase biosynthetic process
B0070372biological_processregulation of ERK1 and ERK2 cascade
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0070664biological_processnegative regulation of leukocyte proliferation
B0071222biological_processcellular response to lipopolysaccharide
B0071364biological_processcellular response to epidermal growth factor stimulus
B0071385biological_processcellular response to glucocorticoid stimulus
B0071460biological_processcellular response to cell-matrix adhesion
B0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
B0071672biological_processnegative regulation of smooth muscle cell chemotaxis
B0097159molecular_functionorganic cyclic compound binding
B1901687biological_processglutathione derivative biosynthetic process
B1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
B2000429biological_processnegative regulation of neutrophil aggregation
B2000469biological_processnegative regulation of peroxidase activity
B2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE GSH A 210
ChainResidue
AARG13
ATRP38
ALYS44
AGLN51
ALEU52
AGLN64
ASER65
AHOH228
AHOH231
AHOH274
AHOH276
BASP98

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GSH B 210
ChainResidue
AASP98
BTYR7
BPHE8
BARG13
BTRP38
BLYS44
BGLN51
BLEU52
BGLN64
BSER65
BHOH212
BHOH219
BHOH242

site_idGAS
Number of Residues8
DetailsASP 98 BELONGS TO MONOMER B.
ChainResidue
ATYR7
ATRP38
ALYS44
AGLN51
ALEU52
AGLN64
ASER65
BASP98

site_idGBS
Number of Residues8
DetailsASP 98 BELONGS TO MONOMER A.
ChainResidue
BTRP38
BLYS44
BGLN51
BLEU52
BGLN64
BSER65
AASP98
BTYR7

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:8145243
ChainResidueDetails
APHE8
BPRO45
BLEU52
BSER65
ACYS14
AMET39
APRO45
ALEU52
ASER65
BPHE8
BCYS14
BMET39

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by EGFR => ECO:0000250|UniProtKB:P09211
ChainResidueDetails
ATHR4
BTHR4

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P09211
ChainResidueDetails
ALEU62
BLEU62

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337
ChainResidueDetails
ATYR103
AASN116
BTYR103
BASN116

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P09211
ChainResidueDetails
APRO128
BPRO128

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon