1GSE
GLUTATHIONE TRANSFERASE A1-1 COMPLEXED WITH AN ETHACRYNIC ACID GLUTATHIONE CONJUGATE (MUTANT R15K)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0004602 | molecular_function | glutathione peroxidase activity |
| A | 0004769 | molecular_function | steroid Delta-isomerase activity |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006693 | biological_process | prostaglandin metabolic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0030855 | biological_process | epithelial cell differentiation |
| A | 0042167 | biological_process | heme catabolic process |
| A | 0043651 | biological_process | linoleic acid metabolic process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0140104 | molecular_function | molecular carrier activity |
| A | 1901687 | biological_process | glutathione derivative biosynthetic process |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0004602 | molecular_function | glutathione peroxidase activity |
| B | 0004769 | molecular_function | steroid Delta-isomerase activity |
| B | 0005504 | molecular_function | fatty acid binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006693 | biological_process | prostaglandin metabolic process |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0030855 | biological_process | epithelial cell differentiation |
| B | 0042167 | biological_process | heme catabolic process |
| B | 0043651 | biological_process | linoleic acid metabolic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0140104 | molecular_function | molecular carrier activity |
| B | 1901687 | biological_process | glutathione derivative biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GSH A 223 |
| Chain | Residue |
| A | TYR9 |
| A | HOH297 |
| A | HOH406 |
| B | ASP101 |
| B | ARG131 |
| B | HOH285 |
| A | ARG45 |
| A | GLN54 |
| A | VAL55 |
| A | PRO56 |
| A | GLN67 |
| A | THR68 |
| A | EAA224 |
| A | HOH236 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE EAA A 224 |
| Chain | Residue |
| A | TYR9 |
| A | PHE10 |
| A | ARG13 |
| A | GLY14 |
| A | LYS15 |
| A | LEU107 |
| A | LEU108 |
| A | VAL111 |
| A | MET208 |
| A | ALA216 |
| A | PHE220 |
| A | PHE222 |
| A | GSH223 |
| A | HOH312 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME A 225 |
| Chain | Residue |
| A | SER18 |
| A | ILE96 |
| A | BME226 |
| A | HOH378 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BME A 226 |
| Chain | Residue |
| A | ARG69 |
| A | LEU72 |
| A | ILE96 |
| A | GLU97 |
| A | HIS159 |
| A | BME225 |
| A | HOH227 |
| A | HOH289 |
| A | HOH379 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GSH B 223 |
| Chain | Residue |
| A | ASP101 |
| A | ARG131 |
| A | HOH284 |
| B | TYR9 |
| B | ARG45 |
| B | GLN54 |
| B | VAL55 |
| B | PRO56 |
| B | GLN67 |
| B | THR68 |
| B | EAA224 |
| B | HOH242 |
| B | HOH300 |
| B | HOH301 |
| B | HOH320 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE EAA B 224 |
| Chain | Residue |
| B | TYR9 |
| B | PHE10 |
| B | ARG13 |
| B | GLY14 |
| B | LYS15 |
| B | LEU107 |
| B | LEU108 |
| B | PRO110 |
| B | VAL111 |
| B | MET208 |
| B | ALA216 |
| B | PHE220 |
| B | GSH223 |
| B | HOH241 |
| B | HOH316 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME B 225 |
| Chain | Residue |
| B | SER18 |
| B | ILE96 |
| B | BME226 |
| B | HOH344 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BME B 226 |
| Chain | Residue |
| B | ARG69 |
| B | ILE96 |
| B | GLU97 |
| B | HIS159 |
| B | BME225 |
| B | HOH233 |
| B | HOH291 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 244 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16421451","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19618965","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine; in Glutathione S-transferase A1, N-terminally processed","evidences":[{"source":"UniProtKB","id":"P30115","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P30115","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| A | TYR9 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| B | TYR9 |
