1GR2

STRUCTURE OF A GLUTAMATE RECEPTOR LIGAND BINDING CORE (GLUR2) COMPLEXED WITH KAINATE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE KAI A 999

Chain	Residue
A	GLU25
A	MET212
A	HOH1001
A	HOH1084
A	TYR73
A	PRO101
A	THR103
A	ARG108
A	GLY157
A	SER158
A	THR159
A	GLU209

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	TRANSMEM: Helical

Chain	Residue	Details
A	GLN146-SER166
A	ARG219-ALA239

---

site_id	SWS_FT_FI2
Number of Residues	31
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
A	LYS167-GLY193
A	ASN213-GLN218

---

site_id	SWS_FT_FI3
Number of Residues	15
Details	INTRAMEM: Helical; Pore-forming

Chain	Residue	Details
A	VAL194-GLU209

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	INTRAMEM:

Chain	Residue	Details
A	SER210-MET212

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO101
A	THR103
A	ARG108
A	SER158
A	THR159
A	GLU209

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG76
A	ARG164
A	LYS256

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE137

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER166

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER200

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000250

Chain	Residue	Details
A	MET212

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN8
A	ASN15

---