1GQT

Activation of Ribokinase by Monovalent Cations

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004747	molecular_function	ribokinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006014	biological_process	D-ribose metabolic process
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0016301	molecular_function	kinase activity
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
A	0019303	biological_process	D-ribose catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0046835	biological_process	carbohydrate phosphorylation
A	0046872	molecular_function	metal ion binding
B	0004747	molecular_function	ribokinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006014	biological_process	D-ribose metabolic process
B	0006796	biological_process	phosphate-containing compound metabolic process
B	0016301	molecular_function	kinase activity
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0019303	biological_process	D-ribose catabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0046835	biological_process	carbohydrate phosphorylation
B	0046872	molecular_function	metal ion binding
C	0004747	molecular_function	ribokinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006014	biological_process	D-ribose metabolic process
C	0006796	biological_process	phosphate-containing compound metabolic process
C	0016301	molecular_function	kinase activity
C	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
C	0019303	biological_process	D-ribose catabolic process
C	0042803	molecular_function	protein homodimerization activity
C	0046835	biological_process	carbohydrate phosphorylation
C	0046872	molecular_function	metal ion binding
D	0004747	molecular_function	ribokinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006014	biological_process	D-ribose metabolic process
D	0006796	biological_process	phosphate-containing compound metabolic process
D	0016301	molecular_function	kinase activity
D	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
D	0019303	biological_process	D-ribose catabolic process
D	0042803	molecular_function	protein homodimerization activity
D	0046835	biological_process	carbohydrate phosphorylation
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00584
Number of Residues	14
Details	PFKB_KINASES_2 pfkB family of carbohydrate kinases signature 2. DTiAAGDtfnGALI

Chain	Residue	Details
A	ASP249-ILE262

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01987, ECO:0000305|PubMed:11786021

Chain	Residue	Details
A	ASP255
B	ASP255
C	ASP255
D	ASP255

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01987, ECO:0000269|PubMed:10438599, ECO:0000269|PubMed:11786021, ECO:0000269|PubMed:9519409

Chain	Residue	Details
A	ASN14
B	GLU143
B	ASN187
B	THR223
B	ASP255
B	HIS279
C	ASN14
C	GLY42
C	GLU143
C	ASN187
C	THR223
A	GLY42
C	ASP255
C	HIS279
D	ASN14
D	GLY42
D	GLU143
D	ASN187
D	THR223
D	ASP255
D	HIS279
A	GLU143
A	ASN187
A	THR223
A	ASP255
A	HIS279
B	ASN14
B	GLY42

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01987, ECO:0000305|PubMed:11786021

Chain	Residue	Details
A	ASP249
B	ARG288
B	GLY290
B	SER294
C	ASP249
C	ILE251
C	ALA285
C	ARG288
C	GLY290
C	SER294
D	ASP249
A	ILE251
D	ILE251
D	ALA285
D	ARG288
D	GLY290
D	SER294
A	ALA285
A	ARG288
A	GLY290
A	SER294
B	ASP249
B	ILE251
B	ALA285

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01987, ECO:0000269|PubMed:10438599, ECO:0000269|PubMed:11786021

Chain	Residue	Details
A	GLY254
B	GLY254
C	GLY254
D	GLY254

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1rk2

Chain	Residue	Details
A	GLY254
A	ASP255
A	ALA253
A	ALA252

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1rk2

Chain	Residue	Details
B	GLY254
B	ASP255
B	ALA253
B	ALA252

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1rk2

Chain	Residue	Details
C	GLY254
C	ASP255
C	ALA253
C	ALA252

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1rk2

Chain	Residue	Details
D	GLY254
D	ASP255
D	ALA253
D	ALA252

---

site_id	MCSA1
Number of Residues	4
Details	M-CSA 663

Chain	Residue	Details
A	ALA252	electrostatic stabiliser, polar interaction
A	ALA253	electrostatic stabiliser, polar interaction
A	GLY254	electrostatic stabiliser, polar interaction
A	ASP255	electrostatic stabiliser, proton acceptor, proton donor

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 663

Chain	Residue	Details
B	ALA252	electrostatic stabiliser, polar interaction
B	ALA253	electrostatic stabiliser, polar interaction
B	GLY254	electrostatic stabiliser, polar interaction
B	ASP255	electrostatic stabiliser, proton acceptor, proton donor

---

site_id	MCSA3
Number of Residues	4
Details	M-CSA 663

Chain	Residue	Details
C	ALA252	electrostatic stabiliser, polar interaction
C	ALA253	electrostatic stabiliser, polar interaction
C	GLY254	electrostatic stabiliser, polar interaction
C	ASP255	electrostatic stabiliser, proton acceptor, proton donor

---

site_id	MCSA4
Number of Residues	4
Details	M-CSA 663

Chain	Residue	Details
D	ALA252	electrostatic stabiliser, polar interaction
D	ALA253	electrostatic stabiliser, polar interaction
D	GLY254	electrostatic stabiliser, polar interaction
D	ASP255	electrostatic stabiliser, proton acceptor, proton donor

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