1GPL

RP2 LIPASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004806	molecular_function	triacylglycerol lipase activity
A	0006629	biological_process	lipid metabolic process
A	0016298	molecular_function	lipase activity
A	0052689	molecular_function	carboxylic ester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 500

Chain	Residue
A	GLU187
A	ARG190
A	ASP192
A	ASP195
A	HOH519
A	HOH520

---

site_id	CAT
Number of Residues	3
Details	CATALYTIC TRIAD. THE NUCLEOPHILE SER 152 IS LOCATED IN A BETA TURN AND HAS AN EPSILON CONFORMATION, COMMON FEATURE OF SERINE HYDROLASES.

Chain	Residue
A	SER152
A	ASP176
A	HIS263

---

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VHIIGHSLGA

Chain	Residue	Details
A	VAL146-ALA155

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	110
Details	Domain: {"description":"PLAT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00152","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"P54317","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"P54318","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU10037","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8939760","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GPL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	16
Details	Region: {"description":"Required for galactolipase activity","evidences":[{"source":"UniProtKB","id":"P54317","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"UniProtKB","id":"P54317","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---