Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1GPH

STRUCTURE OF THE ALLOSTERIC REGULATORY ENZYME OF PURINE BIOSYNTHESIS

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000287	molecular_function	magnesium ion binding
1	0003824	molecular_function	catalytic activity
1	0004044	molecular_function	amidophosphoribosyltransferase activity
1	0006164	biological_process	purine nucleotide biosynthetic process
1	0006189	biological_process	'de novo' IMP biosynthetic process
1	0009113	biological_process	purine nucleobase biosynthetic process
1	0016740	molecular_function	transferase activity
1	0016757	molecular_function	glycosyltransferase activity
1	0046872	molecular_function	metal ion binding
1	0051536	molecular_function	iron-sulfur cluster binding
1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
2	0000287	molecular_function	magnesium ion binding
2	0003824	molecular_function	catalytic activity
2	0004044	molecular_function	amidophosphoribosyltransferase activity
2	0006164	biological_process	purine nucleotide biosynthetic process
2	0006189	biological_process	'de novo' IMP biosynthetic process
2	0009113	biological_process	purine nucleobase biosynthetic process
2	0016740	molecular_function	transferase activity
2	0016757	molecular_function	glycosyltransferase activity
2	0046872	molecular_function	metal ion binding
2	0051536	molecular_function	iron-sulfur cluster binding
2	0051539	molecular_function	4 iron, 4 sulfur cluster binding
3	0000287	molecular_function	magnesium ion binding
3	0003824	molecular_function	catalytic activity
3	0004044	molecular_function	amidophosphoribosyltransferase activity
3	0006164	biological_process	purine nucleotide biosynthetic process
3	0006189	biological_process	'de novo' IMP biosynthetic process
3	0009113	biological_process	purine nucleobase biosynthetic process
3	0016740	molecular_function	transferase activity
3	0016757	molecular_function	glycosyltransferase activity
3	0046872	molecular_function	metal ion binding
3	0051536	molecular_function	iron-sulfur cluster binding
3	0051539	molecular_function	4 iron, 4 sulfur cluster binding
4	0000287	molecular_function	magnesium ion binding
4	0003824	molecular_function	catalytic activity
4	0004044	molecular_function	amidophosphoribosyltransferase activity
4	0006164	biological_process	purine nucleotide biosynthetic process
4	0006189	biological_process	'de novo' IMP biosynthetic process
4	0009113	biological_process	purine nucleobase biosynthetic process
4	0016740	molecular_function	transferase activity
4	0016757	molecular_function	glycosyltransferase activity
4	0046872	molecular_function	metal ion binding
4	0051536	molecular_function	iron-sulfur cluster binding
4	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	A11
Number of Residues	10
Details

Chain	Residue
1	ASP345
1	ASP346
1	SER347
1	ILE348
1	VAL349
1	ARG350
1	GLY351
1	THR352
1	THR353
1	AMP467

site_id	A12
Number of Residues	11
Details

Chain	Residue
1	TYR242
1	PHE243
1	SER244
1	ARG245
1	PRO246
1	ASP247
1	LYS305
1	AMP468
2	LYS305
2	ASN306
2	ARG307

site_id	A21
Number of Residues	10
Details

Chain	Residue
2	ASP345
2	ASP346
2	SER347
2	ILE348
2	VAL349
2	ARG350
2	GLY351
2	THR352
2	THR353
2	AMP467

site_id	A22
Number of Residues	11
Details

Chain	Residue
2	TYR242
2	PHE243
2	SER244
2	ARG245
2	PRO246
2	ASP247
2	LYS305
2	AMP468
1	LYS305
1	ASN306
1	ARG307

site_id	A31
Number of Residues	10
Details

Chain	Residue
3	ASP345
3	ASP346
3	SER347
3	ILE348
3	VAL349
3	ARG350
3	GLY351
3	THR352
3	THR353
3	AMP467

site_id	A32
Number of Residues	11
Details

Chain	Residue
3	TYR242
3	PHE243
3	SER244
3	ARG245
3	PRO246
3	ASP247
3	LYS305
3	AMP468
4	LYS305
4	ASN306
4	ARG307

site_id	A41
Number of Residues	10
Details

Chain	Residue
4	ASP345
4	ASP346
4	SER347
4	ILE348
4	VAL349
4	ARG350
4	GLY351
4	THR352
4	THR353
4	AMP467

site_id	A42
Number of Residues	11
Details

Chain	Residue
4	LYS305
4	AMP468
3	LYS305
3	ASN306
3	ARG307
4	TYR242
4	PHE243
4	SER244
4	ARG245
4	PRO246
4	ASP247

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 1 466

Chain	Residue
1	CYS236
1	SER237
1	CYS382
1	TYR384
1	THR388
1	CYS437
1	ALA439
1	CYS440

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AMP 1 467

Chain	Residue
1	TYR242
1	SER283
1	ASP345
1	ASP346
1	SER347
1	VAL349
1	ARG350
1	GLY351
1	THR352
1	THR353
1	THR388
1	SER389

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AMP 1 468

Chain	Residue
1	TYR242
1	SER244
1	ARG245
1	PRO246
1	ARG259
1	PRO281
1	ASP282
1	SER283
1	LYS305
2	ILE304
2	LYS305
2	ARG307

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SF4 2 466

Chain	Residue
2	CYS236
2	SER237
2	CYS382
2	TYR384
2	THR388
2	CYS437
2	CYS440

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AMP 2 467

Chain	Residue
2	TYR73
2	TYR242
2	SER283
2	ASP345
2	ASP346
2	SER347
2	VAL349
2	ARG350
2	GLY351
2	THR352
2	THR353
2	ASP387

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AMP 2 468

Chain	Residue
1	ILE304
1	LYS305
1	ARG307
2	TYR242
2	SER244
2	ARG245
2	ARG259
2	PRO281
2	ASP282
2	SER283
2	LYS305

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SF4 3 466

Chain	Residue
3	CYS236
3	SER237
3	MET238
3	CYS382
3	TYR384
3	THR388
3	CYS437
3	ALA439
3	CYS440

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AMP 3 467

Chain	Residue
3	MET238
3	TYR242
3	SER283
3	ASP345
3	ASP346
3	SER347
3	VAL349
3	ARG350
3	GLY351
3	THR352
3	THR353
3	THR388
3	SER389
3	AMP468

site_id	AC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AMP 3 468

Chain	Residue
3	TYR242
3	SER244
3	ARG245
3	PRO246
3	ARG259
3	PRO281
3	ASP282
3	SER283
3	LYS305
3	AMP467
4	LYS305
4	ARG307

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SF4 4 466

Chain	Residue
4	CYS236
4	SER237
4	MET238
4	CYS382
4	TYR384
4	THR388
4	CYS437
4	CYS440

site_id	BC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AMP 4 467

Chain	Residue
4	TYR242
4	SER283
4	ASP345
4	ASP346
4	SER347
4	VAL349
4	ARG350
4	GLY351
4	THR352
4	THR353
4	ASP387
4	THR388
4	SER389

site_id	BC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AMP 4 468

Chain	Residue
3	ILE304
3	LYS305
3	ARG307
4	TYR242
4	SER244
4	ARG245
4	PRO246
4	ARG259
4	PRO281
4	ASP282
4	SER283
4	LYS305

site_id	FS1
Number of Residues	5
Details

Chain	Residue
1	SF4466
1	CYS236
1	CYS382
1	CYS437
1	CYS440

site_id	FS2
Number of Residues	5
Details

Chain	Residue
2	CYS440
2	SF4466
2	CYS236
2	CYS382
2	CYS437

site_id	FS3
Number of Residues	5
Details

Chain	Residue
3	SF4466
3	CYS236
3	CYS382
3	CYS437
3	CYS440

site_id	FS4
Number of Residues	5
Details

Chain	Residue
4	SF4466
4	CYS236
4	CYS382
4	CYS437
4	CYS440

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VVMVDDSIVRGtT

Chain	Residue	Details
1	VAL341-THR353

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	876
Details	Domain: {"description":"Glutamine amidotransferase type-2","evidences":[{"source":"HAMAP-Rule","id":"MF_01931","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01931","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"6411716","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01931","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8197456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9271502","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01931","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9271502","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
1	ASP345
1	LYS372
1	VAL349
1	ASP346

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
2	GLY324

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
3	GLY324

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
4	GLY324

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
2	ASP345
2	LYS372
2	VAL349
2	ASP346

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
3	ASP345
3	LYS372
3	VAL349
3	ASP346

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
4	ASP345
4	LYS372
4	VAL349
4	ASP346

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
1	GLY103
1	ASN102
1	CYS1

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
2	GLY103
2	ASN102
2	CYS1

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
3	GLY103
3	ASN102
3	CYS1

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
4	GLY103
4	ASN102
4	CYS1

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
1	GLY324

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)