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1GO4

Crystal structure of Mad1-Mad2 reveals a conserved Mad2 binding motif in Mad1 and Cdc20.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000070biological_processmitotic sister chromatid segregation
A0000132biological_processestablishment of mitotic spindle orientation
A0000775cellular_componentchromosome, centromeric region
A0000776cellular_componentkinetochore
A0000922cellular_componentspindle pole
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0007094biological_processmitotic spindle assembly checkpoint signaling
A0033597cellular_componentmitotic checkpoint complex
A0042177biological_processnegative regulation of protein catabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043066biological_processnegative regulation of apoptotic process
A0044615cellular_componentnuclear pore nuclear basket
A0045930biological_processnegative regulation of mitotic cell cycle
A0048471cellular_componentperinuclear region of cytoplasm
A0051301biological_processcell division
A0051660biological_processestablishment of centrosome localization
A0072686cellular_componentmitotic spindle
A0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
A1904667biological_processnegative regulation of ubiquitin protein ligase activity
A1990728cellular_componentmitotic spindle assembly checkpoint MAD1-MAD2 complex
B0000070biological_processmitotic sister chromatid segregation
B0000132biological_processestablishment of mitotic spindle orientation
B0000775cellular_componentchromosome, centromeric region
B0000776cellular_componentkinetochore
B0000922cellular_componentspindle pole
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0007094biological_processmitotic spindle assembly checkpoint signaling
B0033597cellular_componentmitotic checkpoint complex
B0042177biological_processnegative regulation of protein catabolic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043066biological_processnegative regulation of apoptotic process
B0044615cellular_componentnuclear pore nuclear basket
B0045930biological_processnegative regulation of mitotic cell cycle
B0048471cellular_componentperinuclear region of cytoplasm
B0051301biological_processcell division
B0051660biological_processestablishment of centrosome localization
B0072686cellular_componentmitotic spindle
B0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
B1904667biological_processnegative regulation of ubiquitin protein ligase activity
B1990728cellular_componentmitotic spindle assembly checkpoint MAD1-MAD2 complex
C0000070biological_processmitotic sister chromatid segregation
C0000132biological_processestablishment of mitotic spindle orientation
C0000775cellular_componentchromosome, centromeric region
C0000776cellular_componentkinetochore
C0000922cellular_componentspindle pole
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0007094biological_processmitotic spindle assembly checkpoint signaling
C0033597cellular_componentmitotic checkpoint complex
C0042177biological_processnegative regulation of protein catabolic process
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043066biological_processnegative regulation of apoptotic process
C0044615cellular_componentnuclear pore nuclear basket
C0045930biological_processnegative regulation of mitotic cell cycle
C0048471cellular_componentperinuclear region of cytoplasm
C0051301biological_processcell division
C0051660biological_processestablishment of centrosome localization
C0072686cellular_componentmitotic spindle
C0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
C1904667biological_processnegative regulation of ubiquitin protein ligase activity
C1990728cellular_componentmitotic spindle assembly checkpoint MAD1-MAD2 complex
D0000070biological_processmitotic sister chromatid segregation
D0000132biological_processestablishment of mitotic spindle orientation
D0000775cellular_componentchromosome, centromeric region
D0000776cellular_componentkinetochore
D0000922cellular_componentspindle pole
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0007094biological_processmitotic spindle assembly checkpoint signaling
D0033597cellular_componentmitotic checkpoint complex
D0042177biological_processnegative regulation of protein catabolic process
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043066biological_processnegative regulation of apoptotic process
D0044615cellular_componentnuclear pore nuclear basket
D0045930biological_processnegative regulation of mitotic cell cycle
D0048471cellular_componentperinuclear region of cytoplasm
D0051301biological_processcell division
D0051660biological_processestablishment of centrosome localization
D0072686cellular_componentmitotic spindle
D0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
D1904667biological_processnegative regulation of ubiquitin protein ligase activity
D1990728cellular_componentmitotic spindle assembly checkpoint MAD1-MAD2 complex
E0007094biological_processmitotic spindle assembly checkpoint signaling
F0007094biological_processmitotic spindle assembly checkpoint signaling
G0007094biological_processmitotic spindle assembly checkpoint signaling
H0007094biological_processmitotic spindle assembly checkpoint signaling
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
EARG520
FARG520
GARG520
HARG520

site_idSWS_FT_FI2
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER6
DSER6
DSER130
DSER185
ASER130
ASER185
BSER6
BSER130
BSER185
CSER6
CSER130
CSER185

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:12574116
ChainResidueDetails
ASER170
ASER178
BSER170
BSER178
CSER170
CSER178
DSER170
DSER178

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:12574116, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER195
BSER195
CSER195
DSER195

219140

PDB entries from 2024-05-01

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