1GO4

Crystal structure of Mad1-Mad2 reveals a conserved Mad2 binding motif in Mad1 and Cdc20.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000070	biological_process	mitotic sister chromatid segregation
A	0000775	cellular_component	chromosome, centromeric region
A	0000776	cellular_component	kinetochore
A	0000922	cellular_component	spindle pole
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007094	biological_process	mitotic spindle assembly checkpoint signaling
A	0033597	cellular_component	mitotic checkpoint complex
A	0042177	biological_process	negative regulation of protein catabolic process
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044615	cellular_component	nuclear pore nuclear basket
A	0045930	biological_process	negative regulation of mitotic cell cycle
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051301	biological_process	cell division
A	0051783	biological_process	regulation of nuclear division
A	0072686	cellular_component	mitotic spindle
A	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
A	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
A	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
A	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
B	0000070	biological_process	mitotic sister chromatid segregation
B	0000775	cellular_component	chromosome, centromeric region
B	0000776	cellular_component	kinetochore
B	0000922	cellular_component	spindle pole
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007094	biological_process	mitotic spindle assembly checkpoint signaling
B	0033597	cellular_component	mitotic checkpoint complex
B	0042177	biological_process	negative regulation of protein catabolic process
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0044615	cellular_component	nuclear pore nuclear basket
B	0045930	biological_process	negative regulation of mitotic cell cycle
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051301	biological_process	cell division
B	0051783	biological_process	regulation of nuclear division
B	0072686	cellular_component	mitotic spindle
B	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
B	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
B	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
B	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
C	0000070	biological_process	mitotic sister chromatid segregation
C	0000775	cellular_component	chromosome, centromeric region
C	0000776	cellular_component	kinetochore
C	0000922	cellular_component	spindle pole
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007094	biological_process	mitotic spindle assembly checkpoint signaling
C	0033597	cellular_component	mitotic checkpoint complex
C	0042177	biological_process	negative regulation of protein catabolic process
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0044615	cellular_component	nuclear pore nuclear basket
C	0045930	biological_process	negative regulation of mitotic cell cycle
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051301	biological_process	cell division
C	0051783	biological_process	regulation of nuclear division
C	0072686	cellular_component	mitotic spindle
C	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
C	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
C	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
C	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
D	0000070	biological_process	mitotic sister chromatid segregation
D	0000775	cellular_component	chromosome, centromeric region
D	0000776	cellular_component	kinetochore
D	0000922	cellular_component	spindle pole
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007094	biological_process	mitotic spindle assembly checkpoint signaling
D	0033597	cellular_component	mitotic checkpoint complex
D	0042177	biological_process	negative regulation of protein catabolic process
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0044615	cellular_component	nuclear pore nuclear basket
D	0045930	biological_process	negative regulation of mitotic cell cycle
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051301	biological_process	cell division
D	0051783	biological_process	regulation of nuclear division
D	0072686	cellular_component	mitotic spindle
D	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
D	1901991	biological_process	negative regulation of mitotic cell cycle phase transition
D	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
D	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
E	0007094	biological_process	mitotic spindle assembly checkpoint signaling
F	0007094	biological_process	mitotic spindle assembly checkpoint signaling
G	0007094	biological_process	mitotic spindle assembly checkpoint signaling
H	0007094	biological_process	mitotic spindle assembly checkpoint signaling

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	732
Details	Domain: {"description":"HORMA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00109","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"12574116","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"12574116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	44
Details	Region: {"description":"Necessary for interaction with MAD2L1","evidences":[{"source":"PubMed","id":"19010891","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---