Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1GLA

STRUCTURE OF THE REGULATORY COMPLEX OF ESCHERICHIA COLI IIIGLC WITH GLYCEROL KINASE

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009401	biological_process	phosphoenolpyruvate-dependent sugar phosphotransferase system
F	0009898	cellular_component	cytoplasmic side of plasma membrane
F	0016020	cellular_component	membrane
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0034763	biological_process	negative regulation of transmembrane transport
F	0043610	biological_process	regulation of carbohydrate utilization
F	0045912	biological_process	negative regulation of carbohydrate metabolic process
F	0046872	molecular_function	metal ion binding
F	1902344	biological_process	negative regulation of maltose transport
F	1902495	cellular_component	transmembrane transporter complex
F	1990154	cellular_component	enzyme IIA-maltose transporter complex
G	0000166	molecular_function	nucleotide binding
G	0003824	molecular_function	catalytic activity
G	0004370	molecular_function	glycerol kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005829	cellular_component	cytosol
G	0005975	biological_process	carbohydrate metabolic process
G	0006071	biological_process	glycerol metabolic process
G	0006072	biological_process	glycerol-3-phosphate metabolic process
G	0006974	biological_process	DNA damage response
G	0008270	molecular_function	zinc ion binding
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
G	0019563	biological_process	glycerol catabolic process
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL G 600

Chain	Residue
G	GLN82
G	ARG83
G	GLU84
G	TRP103
G	TYR135
G	ASP245
G	PHE270

Functional Information from PROSITE/UniProt

site_id	PS00371
Number of Residues	13
Details	PTS_EIIA_TYPE_1_HIS PTS EIIA domains phosphorylation site signature 1. GveLFVHFGIdTV

Chain	Residue	Details
F	GLY84-VAL96

site_id	PS00445
Number of Residues	21
Details	FGGY_KINASES_2 FGGY family of carbohydrate kinases signature 2. GaIFGLtrgvnan.HIIRATLE

Chain	Residue	Details
G	GLY362-GLU382

site_id	PS00933
Number of Residues	13
Details	FGGY_KINASES_1 FGGY family of carbohydrate kinases signature 1. YfSgtKVKWILDH

Chain	Residue	Details
G	TYR135-HIS147

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	104
Details	Domain: {"description":"PTS EIIA type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00416","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Tele-phosphohistidine intermediate; for EIIA activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00416","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"2657735","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6383826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1961703","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9405042","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"2657735","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8170944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9405042","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1961703","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Important for phospho-donor activity","evidences":[{"source":"PubMed","id":"2657735","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphohistidine; by HPr","evidences":[{"source":"PubMed","id":"2657735","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8170944","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GLC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GLE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10090737","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1BWF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GLJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GLL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10090737","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1GLJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8170944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8430315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9817843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GLB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GLE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GLF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8430315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9843423","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BO5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BOT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10090737","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1BWF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GLL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8170944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8430315","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GLB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GLC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GLE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1gpr

Chain	Residue	Details
F	HIS90
F	HIS75
F	GLY92
F	THR73

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)