Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003690 | molecular_function | double-stranded DNA binding |
| A | 0003697 | molecular_function | single-stranded DNA binding |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0043418 | biological_process | homocysteine catabolic process |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 801 |
| Chain | Residue |
| A | ASN66 |
| A | GLY395 |
| A | LYS396 |
| A | HOH675 |
| A | HOH714 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 802 |
| Chain | Residue |
| A | ARG192 |
| A | LYS196 |
| A | TYR362 |
| A | HOH643 |
| A | HOH644 |
| A | ILE126 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 803 |
| Chain | Residue |
| A | LYS175 |
| A | SER178 |
| A | PRO328 |
| A | LYS329 |
| A | HOH691 |
| A | HOH697 |
| A | HOH698 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG A 901 |
| Chain | Residue |
| A | PHE411 |
| A | CYS415 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG A 902 |
| Chain | Residue |
| A | THR55 |
| A | CYS376 |
| A | VAL378 |
| A | HG903 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG A 903 |
| Chain | Residue |
| A | VAL312 |
| A | CYS376 |
| A | PRO385 |
| A | HG902 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG A 904 |
| Chain | Residue |
| A | GLY71 |
| A | CYS73 |
| A | ALA453 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 851 |
| Chain | Residue |
| A | GLN81 |
| A | LEU82 |
| A | ASN85 |
| A | LYS262 |
| A | ARG314 |
| A | LYS319 |
| A | ASP421 |
| A | HOH684 |
| site_id | CAT |
| Number of Residues | 3 |
| Details | |
| Chain | Residue |
| A | CYS73 |
| A | HIS369 |
| A | ASN392 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QKsSGRCWLfAA |
| Chain | Residue | Details |
| A | GLN67-ALA78 | |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MTHAMLITGCH |
| Chain | Residue | Details |
| A | MET367-HIS377 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | LEU102 | |
| A | SER398 | |
| A | ASP421 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 9546396, 7638617 |
| Chain | Residue | Details |
| A | ASN392 | |
| A | CYS73 | |
| A | CYS73 | |
| A | HIS369 | |
| A | GLN67 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 624 |
| Chain | Residue | Details |
| A | GLU96 | electrostatic stabiliser |
| A | LEU102 | electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | SER398 | proton acceptor, proton donor |
| A | ASP421 | electrostatic stabiliser |
