1G9T

CRYSTAL STRUCTURE OF E.COLI HPRT-GMP COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0006178	biological_process	guanine salvage
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0046100	biological_process	hypoxanthine metabolic process
A	0046872	molecular_function	metal ion binding
A	0051289	biological_process	protein homotetramerization
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
A	0097216	molecular_function	guanosine tetraphosphate binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0006178	biological_process	guanine salvage
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0046100	biological_process	hypoxanthine metabolic process
B	0046872	molecular_function	metal ion binding
B	0051289	biological_process	protein homotetramerization
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0097216	molecular_function	guanosine tetraphosphate binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 5GP A 190

Chain	Residue
A	GLU103
A	PHE156
A	VAL157
A	ILE162
A	ASP163
A	HOH1001
A	HOH1011
A	HOH1090
A	ILE105
A	ASP107
A	SER108
A	GLY109
A	ASN110
A	THR111
A	LEU112
A	LYS135

---

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIIDSGnT

Chain	Residue	Details
A	VAL99-THR111

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:12070315

Chain	Residue	Details
A	ASP107
B	ASP407

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P9WHQ9

Chain	Residue	Details
B	GLY348
B	ARG469
A	GLY48
A	ARG169
B	ARG347
A	ARG47

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:12070315, ECO:0007744|PDB:1GRV

Chain	Residue	Details
B	GLU403
B	ASP404
A	GLU103
A	ASP104

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:12070315, ECO:0007744|PDB:1G9S

Chain	Residue	Details
B	ASP407
B	LYS435
A	LYS135
A	ASP107

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:12070315, ECO:0007744|PDB:1G9T

Chain	Residue	Details
A	ASP163
B	ASP463

---