1G73

CRYSTAL STRUCTURE OF SMAC BOUND TO XIAP-BIR3 DOMAIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0006915	biological_process	apoptotic process
A	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process
B	0005739	cellular_component	mitochondrion
B	0006915	biological_process	apoptotic process
B	0006919	biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 501

Chain	Residue
C	CYS300
C	CYS303
C	HIS320
C	CYS327

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 502

Chain	Residue
D	CYS300
D	CYS303
D	HIS320
D	CYS327

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Functional Information from PROSITE/UniProt

site_id	PS01282
Number of Residues	66
Details	BIR_REPEAT_1 BIR repeat. YeaRiftfgt.Wiysvnkeqlar...AGFyAlgegDkvkCfhCgggltdWkpsedpweqHakwyPgCkyL

Chain	Residue	Details
C	TYR265-LEU330

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00029

Chain	Residue	Details
C	CYS300
C	CYS303
C	HIS320
C	CYS327
D	CYS300
D	CYS303
D	HIS320
D	CYS327

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site_id	SWS_FT_FI2
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:12747801

Chain	Residue	Details
C	LYS322
C	LYS328
D	LYS322
D	LYS328

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