1G50
CRYSTAL STRUCTURE OF A WILD TYPE HER ALPHA LBD AT 2.9 ANGSTROM RESOLUTION
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EST A 600 |
| Chain | Residue |
| A | GLU353 |
| A | LEU387 |
| A | MET388 |
| A | ARG394 |
| A | PHE404 |
| A | MET421 |
| A | HIS524 |
| A | LEU525 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE EST B 1600 |
| Chain | Residue |
| B | LEU1387 |
| B | MET1388 |
| B | LEU1391 |
| B | ARG1394 |
| B | PHE1404 |
| B | MET1421 |
| B | ILE1424 |
| B | GLY1521 |
| B | HIS1524 |
| B | LEU1525 |
| B | GLU1353 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EST C 2600 |
| Chain | Residue |
| C | GLU2353 |
| C | LEU2387 |
| C | MET2388 |
| C | LEU2391 |
| C | ARG2394 |
| C | PHE2404 |
| C | ILE2424 |
| C | GLY2521 |
| C | HIS2524 |
| C | LEU2525 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| A | GLU353 | |
| A | ARG394 | |
| A | HIS524 | |
| B | GLU1353 | |
| B | ARG1394 | |
| B | HIS1524 | |
| C | GLU2353 | |
| C | ARG2394 | |
| C | HIS2524 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| A | TYR537 | |
| B | TYR1537 | |
| C | TYR2537 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS1447 | |
| C | CYS2447 |
