1G4I

Crystal structure of the bovine pancreatic phospholipase A2 at 0.97A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002227	biological_process	innate immune response in mucosa
A	0004623	molecular_function	phospholipase A2 activity
A	0005102	molecular_function	signaling receptor binding
A	0005509	molecular_function	calcium ion binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006629	biological_process	lipid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006644	biological_process	phospholipid metabolic process
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009986	cellular_component	cell surface
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0019731	biological_process	antibacterial humoral response
A	0032052	molecular_function	bile acid binding
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046872	molecular_function	metal ion binding
A	0047498	molecular_function	calcium-dependent phospholipase A2 activity
A	0048146	biological_process	positive regulation of fibroblast proliferation
A	0050482	biological_process	arachidonic acid secretion
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	1904635	biological_process	positive regulation of podocyte apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 124

Chain	Residue
A	TYR28
A	GLY30
A	GLY32
A	ASP49
A	HOH136
A	HOH143

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 125

Chain	Residue
A	HOH356
A	LYS12
A	ILE82
A	ARG100

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MRD A 127

Chain	Residue
A	ASN6
A	PHE22
A	ASN23
A	GLY30
A	MPD126
A	MRD128
A	HOH136

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MRD A 128

Chain	Residue
A	LEU2
A	PHE5
A	ASN6
A	PRO18
A	LEU19
A	PHE22
A	ASN23
A	CYS29
A	GLY30
A	PHE106
A	MPD126
A	MRD127

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD A 129

Chain	Residue
A	SER15
A	SER16
A	ASP21
A	GLN54
A	HOH162

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 126

Chain	Residue
A	GLY30
A	LEU31
A	MRD127
A	MRD128
A	HOH136
A	HOH169
A	HOH240

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MPD A 130

Chain	Residue
A	LYS10
A	GLU17
A	LEU19
A	LEU20
A	CYS105
A	VAL109
A	HOH141
A	HOH149
A	HOH189
A	HOH315
A	HOH357
A	HOH358

---

Functional Information from PROSITE/UniProt

site_id	PS00118
Number of Residues	8
Details	PA2_HIS Phospholipase A2 histidine active site. CCQtHDnC

Chain	Residue	Details
A	CYS44-CYS51

---

site_id	PS00119
Number of Residues	11
Details	PA2_ASP Phospholipase A2 aspartic acid active site. ICNCDRNAaIC

Chain	Residue	Details
A	ILE95-CYS105

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:7464926

Chain	Residue	Details
A	HIS48
A	ASP99

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:10089353, ECO:0000269|PubMed:7265241, ECO:0000269|PubMed:9115986, ECO:0007744|PDB:1BP2, ECO:0007744|PDB:1KVW, ECO:0007744|PDB:1MKS

Chain	Residue	Details
A	TYR28
A	GLY30
A	GLY32
A	ASP49

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29

Chain	Residue	Details
A	HIS48
A	GLY30
A	ASP99

---