Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1G3N

STRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000082	biological_process	G1/S transition of mitotic cell cycle
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000166	molecular_function	nucleotide binding
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0001726	cellular_component	ruffle
A	0001954	biological_process	positive regulation of cell-matrix adhesion
A	0002244	biological_process	hematopoietic progenitor cell differentiation
A	0003323	biological_process	type B pancreatic cell development
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0006468	biological_process	protein phosphorylation
A	0006974	biological_process	DNA damage response
A	0007165	biological_process	signal transduction
A	0007219	biological_process	Notch signaling pathway
A	0008285	biological_process	negative regulation of cell population proliferation
A	0009615	biological_process	response to virus
A	0010389	biological_process	regulation of G2/M transition of mitotic cell cycle
A	0010468	biological_process	regulation of gene expression
A	0010628	biological_process	positive regulation of gene expression
A	0014002	biological_process	astrocyte development
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0021542	biological_process	dentate gyrus development
A	0021670	biological_process	lateral ventricle development
A	0030097	biological_process	hemopoiesis
A	0030154	biological_process	cell differentiation
A	0030332	molecular_function	cyclin binding
A	0033077	biological_process	T cell differentiation in thymus
A	0042063	biological_process	gliogenesis
A	0042127	biological_process	regulation of cell population proliferation
A	0042995	cellular_component	cell projection
A	0043697	biological_process	cell dedifferentiation
A	0045596	biological_process	negative regulation of cell differentiation
A	0045638	biological_process	negative regulation of myeloid cell differentiation
A	0045646	biological_process	regulation of erythrocyte differentiation
A	0045656	biological_process	negative regulation of monocyte differentiation
A	0045668	biological_process	negative regulation of osteoblast differentiation
A	0045786	biological_process	negative regulation of cell cycle
A	0048146	biological_process	positive regulation of fibroblast proliferation
A	0048699	biological_process	generation of neurons
A	0050680	biological_process	negative regulation of epithelial cell proliferation
A	0051301	biological_process	cell division
A	0051726	biological_process	regulation of cell cycle
A	0060218	biological_process	hematopoietic stem cell differentiation
A	0097131	cellular_component	cyclin D1-CDK6 complex
A	0097132	cellular_component	cyclin D2-CDK6 complex
A	0097133	cellular_component	cyclin D3-CDK6 complex
A	0098770	molecular_function	FBXO family protein binding
A	0106310	molecular_function	protein serine kinase activity
A	1902036	biological_process	regulation of hematopoietic stem cell differentiation
A	2000145	biological_process	regulation of cell motility
A	2000773	biological_process	negative regulation of cellular senescence
B	0004861	molecular_function	cyclin-dependent protein serine/threonine kinase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008283	biological_process	cell population proliferation
B	0008285	biological_process	negative regulation of cell population proliferation
B	0019901	molecular_function	protein kinase binding
B	0030308	biological_process	negative regulation of cell growth
B	0048709	biological_process	oligodendrocyte differentiation
B	0072089	biological_process	stem cell proliferation
B	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
B	2000647	biological_process	negative regulation of stem cell proliferation
C	0005515	molecular_function	protein binding
E	0000082	biological_process	G1/S transition of mitotic cell cycle
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000166	molecular_function	nucleotide binding
E	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
E	0001726	cellular_component	ruffle
E	0001954	biological_process	positive regulation of cell-matrix adhesion
E	0002244	biological_process	hematopoietic progenitor cell differentiation
E	0003323	biological_process	type B pancreatic cell development
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0006468	biological_process	protein phosphorylation
E	0006974	biological_process	DNA damage response
E	0007165	biological_process	signal transduction
E	0007219	biological_process	Notch signaling pathway
E	0008285	biological_process	negative regulation of cell population proliferation
E	0009615	biological_process	response to virus
E	0010389	biological_process	regulation of G2/M transition of mitotic cell cycle
E	0010468	biological_process	regulation of gene expression
E	0010628	biological_process	positive regulation of gene expression
E	0014002	biological_process	astrocyte development
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0021542	biological_process	dentate gyrus development
E	0021670	biological_process	lateral ventricle development
E	0030097	biological_process	hemopoiesis
E	0030154	biological_process	cell differentiation
E	0030332	molecular_function	cyclin binding
E	0033077	biological_process	T cell differentiation in thymus
E	0042063	biological_process	gliogenesis
E	0042127	biological_process	regulation of cell population proliferation
E	0042995	cellular_component	cell projection
E	0043697	biological_process	cell dedifferentiation
E	0045596	biological_process	negative regulation of cell differentiation
E	0045638	biological_process	negative regulation of myeloid cell differentiation
E	0045646	biological_process	regulation of erythrocyte differentiation
E	0045656	biological_process	negative regulation of monocyte differentiation
E	0045668	biological_process	negative regulation of osteoblast differentiation
E	0045786	biological_process	negative regulation of cell cycle
E	0048146	biological_process	positive regulation of fibroblast proliferation
E	0048699	biological_process	generation of neurons
E	0050680	biological_process	negative regulation of epithelial cell proliferation
E	0051301	biological_process	cell division
E	0051726	biological_process	regulation of cell cycle
E	0060218	biological_process	hematopoietic stem cell differentiation
E	0097131	cellular_component	cyclin D1-CDK6 complex
E	0097132	cellular_component	cyclin D2-CDK6 complex
E	0097133	cellular_component	cyclin D3-CDK6 complex
E	0098770	molecular_function	FBXO family protein binding
E	0106310	molecular_function	protein serine kinase activity
E	1902036	biological_process	regulation of hematopoietic stem cell differentiation
E	2000145	biological_process	regulation of cell motility
E	2000773	biological_process	negative regulation of cellular senescence
F	0004861	molecular_function	cyclin-dependent protein serine/threonine kinase inhibitor activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0008283	biological_process	cell population proliferation
F	0008285	biological_process	negative regulation of cell population proliferation
F	0019901	molecular_function	protein kinase binding
F	0030308	biological_process	negative regulation of cell growth
F	0048709	biological_process	oligodendrocyte differentiation
F	0072089	biological_process	stem cell proliferation
F	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
F	2000647	biological_process	negative regulation of stem cell proliferation
G	0005515	molecular_function	protein binding

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGAYGKVFkArdlknggrf.........VALK

Chain	Residue	Details
A	ILE19-LYS43

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpqNILV

Chain	Residue	Details
A	VAL141-VAL153

site_id	PS00292
Number of Residues	32
Details	CYCLINS Cyclins signature. RklLgtWMfsvcqeynLepnvValALnLLDRL

Chain	Residue	Details
C	ARG51-LEU82

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	ASP145
E	ASP145

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE19
A	LYS43
E	ILE19
E	LYS43

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:22814378

Chain	Residue	Details
A	MET1
E	MET1

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:15592455

Chain	Residue	Details
A	TYR13
E	TYR13

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:15592455, ECO:0007744\|PubMed:19369195

Chain	Residue	Details
A	TYR24
E	TYR24

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:19369195

Chain	Residue	Details
A	THR49
A	THR70
A	THR325
E	THR49
E	THR70
E	THR325

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:11828325

Chain	Residue	Details
A	THR177
E	THR177

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS264
E	LYS264

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP145
A	GLN149

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP145
E	GLN149

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP145
A	LYS147

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP145
E	LYS147

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP145
A	THR182
A	LYS147

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP145
E	THR182
E	LYS147

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP145
A	LYS147
A	ASN150

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP145
E	LYS147
E	ASN150

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)