1G17

CRYSTAL STRUCTURE OF SEC4-GUANOSINE-5'-(BETA,GAMMA)-IMIDOTRIPHOSPHATE

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005935cellular_componentcellular bud neck
A0005783cellular_componentendoplasmic reticulum
A0005768cellular_componentendosome
A0000131cellular_componentincipient cellular bud site
A0043332cellular_componentmating projection tip
A0005741cellular_componentmitochondrial outer membrane
A0005739cellular_componentmitochondrion
A0005886cellular_componentplasma membrane
A0030133cellular_componenttransport vesicle
A0030658cellular_componenttransport vesicle membrane
A0031982cellular_componentvesicle
A0005525molecular_functionGTP binding
A0003924molecular_functionGTPase activity
A0031321biological_processascospore-type prospore assembly
A0006914biological_processautophagy
A0006887biological_processexocytosis
A0006893biological_processGolgi to plasma membrane transport
A0006886biological_processintracellular protein transport
A0007107biological_processmembrane addition at site of cytokinesis
A0072659biological_processprotein localization to plasma membrane
A0009306biological_processprotein secretion
A0032482biological_processRab protein signal transduction
A0017157biological_processregulation of exocytosis
A0006904biological_processvesicle docking involved in exocytosis
A0006906biological_processvesicle fusion
B0005935cellular_componentcellular bud neck
B0005783cellular_componentendoplasmic reticulum
B0005768cellular_componentendosome
B0000131cellular_componentincipient cellular bud site
B0043332cellular_componentmating projection tip
B0005741cellular_componentmitochondrial outer membrane
B0005739cellular_componentmitochondrion
B0005886cellular_componentplasma membrane
B0030133cellular_componenttransport vesicle
B0030658cellular_componenttransport vesicle membrane
B0031982cellular_componentvesicle
B0005525molecular_functionGTP binding
B0003924molecular_functionGTPase activity
B0031321biological_processascospore-type prospore assembly
B0006914biological_processautophagy
B0006887biological_processexocytosis
B0006893biological_processGolgi to plasma membrane transport
B0006886biological_processintracellular protein transport
B0007107biological_processmembrane addition at site of cytokinesis
B0072659biological_processprotein localization to plasma membrane
B0009306biological_processprotein secretion
B0032482biological_processRab protein signal transduction
B0017157biological_processregulation of exocytosis
B0006904biological_processvesicle docking involved in exocytosis
B0006906biological_processvesicle fusion
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC15BINDING SITE FOR RESIDUE MG A 301
ChainResidue
ASER34
ATHR52
AGNP201
AHOH403
AHOH404

AC25BINDING SITE FOR RESIDUE MG B 302
ChainResidue
BSER34
BTHR52
BGNP202
BHOH401
BHOH402

AC327BINDING SITE FOR RESIDUE GNP A 201
ChainResidue
ASER29
AGLY30
AVAL31
AGLY32
ALYS33
ASER34
ACYS35
APHE45
AASN46
APRO47
ASER48
APHE49
ATHR51
ATHR52
AGLY78
AASN133
ALYS134
AASP136
AMET137
ASER162
AALA163
ALYS164
AMG301
AHOH403
AHOH404
AHOH408
AHOH419

AC427BINDING SITE FOR RESIDUE GNP B 202
ChainResidue
BSER29
BGLY30
BVAL31
BGLY32
BLYS33
BSER34
BCYS35
BPHE45
BASN46
BPRO47
BSER48
BPHE49
BTHR51
BTHR52
BGLY78
BASN133
BLYS134
BASP136
BMET137
BSER162
BALA163
BLYS164
BMG302
BHOH401
BHOH402
BHOH406
BHOH421

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
GNP_1g17_A_20130PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER binding site
ChainResidueligand
AGLY27-CYS35GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
APHE45-THR52GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
AASP75-GLN79GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
AASN133-LYS134GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
AASP136-MET137GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
ASER161-LYS164GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER

GNP_1g17_B_20230PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER binding site
ChainResidueligand
BGLY27-CYS35GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
BPHE45-THR52GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
BASP75-GLN79GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
BASN133-LYS134GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
BASP136-MET137GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
BSER161-LYS164GNP: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0067528Sigma-54 interaction domain ATP-binding region A signature. [LIVMFY](3)-x-G-[DEQ]-[STE]-G-[STAV]-G-K-x(2)-[LIVMFY]
ChainResidueDetails
AILE23-LEU36
BILE23-LEU36

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI113GTP.
ChainResidueDetails
AGLY10-SER17
AASP58-GLN62

SWS_FT_FI24GTP (By similarity).
ChainResidueDetails
AASN116-ASP119

SWS_FT_FI313GTP.
ChainResidueDetails
BGLY10-SER17
BASP58-GLN62

SWS_FT_FI44GTP (By similarity).
ChainResidueDetails
BASN116-ASP119

CSA11Annotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN79

CSA21Annotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLN79

CSA31Annotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLY30

CSA41Annotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLY30

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Catalytic Information from CSA

site_idNumber of ResiduesDetails
CSA11Annotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN79

CSA21Annotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLN79

CSA31Annotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLY30

CSA41Annotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLY30