1G0D

CRYSTAL STRUCTURE OF RED SEA BREAM TRANSGLUTAMINASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000785	cellular_component	chromatin
A	0003810	molecular_function	protein-glutamine gamma-glutamyltransferase activity
A	0005509	molecular_function	calcium ion binding
A	0005525	molecular_function	GTP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006338	biological_process	chromatin remodeling
A	0006508	biological_process	proteolysis
A	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
A	0007399	biological_process	nervous system development
A	0008233	molecular_function	peptidase activity
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0018149	biological_process	peptide cross-linking
A	0018277	biological_process	protein deamination
A	0042981	biological_process	regulation of apoptotic process
A	0043065	biological_process	positive regulation of apoptotic process
A	0043547	biological_process	positive regulation of GTPase activity
A	0046872	molecular_function	metal ion binding
A	0050568	molecular_function	protein-glutamine glutaminase activity
A	0051057	biological_process	positive regulation of small GTPase mediated signal transduction
A	0051260	biological_process	protein homooligomerization
A	0060348	biological_process	bone development
A	0120294	molecular_function	peptide serotonyltransferase activity
A	0120295	molecular_function	histone serotonyltransferase activity
A	0120296	molecular_function	peptide dopaminyltransferase activity
A	0120297	molecular_function	histone dopaminyltransferase activity
A	0120298	molecular_function	peptide noradrenalinyltransferase activity
A	0120299	molecular_function	peptide histaminyltransferase activity
A	1903351	biological_process	cellular response to dopamine
A	1904015	biological_process	cellular response to serotonin
A	2000425	biological_process	regulation of apoptotic cell clearance

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 696

Chain	Residue
A	LYS150
A	ARG291
A	TRP351
A	GLU434
A	HIS439
A	HOH845
A	HOH931

---

Functional Information from PROSITE/UniProt

site_id	PS00547
Number of Residues	18
Details	TRANSGLUTAMINASES Transglutaminases active site. GQCWVfAAVacTvLRCLG

Chain	Residue	Details
A	GLY270-GLY287

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10024, ECO:0000305|PubMed:11080504, ECO:0007744|PDB:1G0D

Chain	Residue	Details
A	CYS272
A	HIS332
A	ASP355

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00488

Chain	Residue	Details
A	ASN395
A	ASP397
A	GLU444
A	GLU449

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P21980

Chain	Residue	Details
A	GLU434
A	SER476
A	ALA578

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Important for catalytic activity => ECO:0000305|PubMed:11080504, ECO:0007744|PDB:1G0D

Chain	Residue	Details
A	TYR515

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	a catalytic site defined by CSA, PubMed 11080504

Chain	Residue	Details
A	CYS272
A	CYS272
A	ASP355
A	HIS332
A	TYR515

---