1G0D
CRYSTAL STRUCTURE OF RED SEA BREAM TRANSGLUTAMINASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000785 | cellular_component | chromatin |
| A | 0003810 | molecular_function | protein-glutamine gamma-glutamyltransferase activity |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005694 | cellular_component | chromosome |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| A | 0007399 | biological_process | nervous system development |
| A | 0018149 | biological_process | peptide cross-linking |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0050568 | molecular_function | protein-glutamine glutaminase activity |
| A | 0051057 | biological_process | positive regulation of small GTPase mediated signal transduction |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0060348 | biological_process | bone development |
| A | 0120294 | molecular_function | peptide serotonyltransferase activity |
| A | 0120295 | molecular_function | histone serotonyltransferase activity |
| A | 0120296 | molecular_function | peptide dopaminyltransferase activity |
| A | 0120297 | molecular_function | histone dopaminyltransferase activity |
| A | 0120298 | molecular_function | peptide noradrenalinyltransferase activity |
| A | 0120299 | molecular_function | peptide histaminyltransferase activity |
| A | 1903351 | biological_process | cellular response to dopamine |
| A | 1904015 | biological_process | cellular response to serotonin |
| A | 2000425 | biological_process | regulation of apoptotic cell clearance |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 696 |
| Chain | Residue |
| A | LYS150 |
| A | ARG291 |
| A | TRP351 |
| A | GLU434 |
| A | HIS439 |
| A | HOH845 |
| A | HOH931 |
Functional Information from PROSITE/UniProt
| site_id | PS00547 |
| Number of Residues | 18 |
| Details | TRANSGLUTAMINASES Transglutaminases active site. GQCWVfAAVacTvLRCLG |
| Chain | Residue | Details |
| A | GLY270-GLY287 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10024","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11080504","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1G0D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00488","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P21980","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"PubMed","id":"11080504","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1G0D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 11080504 |
| Chain | Residue | Details |
| A | CYS272 | |
| A | CYS272 | |
| A | ASP355 | |
| A | HIS332 | |
| A | TYR515 |
