1FZW
THE STRUCTURAL BASIS OF THE CATALYTIC MECHANISM AND REGULATION OF GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE (RMLA). APO ENZYME.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000271 | biological_process | polysaccharide biosynthetic process |
| A | 0005829 | cellular_component | cytosol |
| A | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| A | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| B | 0000271 | biological_process | polysaccharide biosynthetic process |
| B | 0005829 | cellular_component | cytosol |
| B | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| B | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| C | 0000271 | biological_process | polysaccharide biosynthetic process |
| C | 0005829 | cellular_component | cytosol |
| C | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| C | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| D | 0000271 | biological_process | polysaccharide biosynthetic process |
| D | 0005829 | cellular_component | cytosol |
| D | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| D | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| E | 0000271 | biological_process | polysaccharide biosynthetic process |
| E | 0005829 | cellular_component | cytosol |
| E | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| E | 0009058 | biological_process | biosynthetic process |
| E | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| E | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| F | 0000271 | biological_process | polysaccharide biosynthetic process |
| F | 0005829 | cellular_component | cytosol |
| F | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| F | 0009058 | biological_process | biosynthetic process |
| F | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| F | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| G | 0000271 | biological_process | polysaccharide biosynthetic process |
| G | 0005829 | cellular_component | cytosol |
| G | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| G | 0009058 | biological_process | biosynthetic process |
| G | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| G | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
| H | 0000271 | biological_process | polysaccharide biosynthetic process |
| H | 0005829 | cellular_component | cytosol |
| H | 0008879 | molecular_function | glucose-1-phosphate thymidylyltransferase activity |
| H | 0009058 | biological_process | biosynthetic process |
| H | 0009244 | biological_process | lipopolysaccharide core region biosynthetic process |
| H | 0019305 | biological_process | dTDP-rhamnose biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 C 3600 |
| Chain | Residue |
| A | HIS116 |
| A | ASP117 |
| C | GLY218 |
| C | ARG219 |
| C | GLY220 |
| C | HOH5007 |
| C | HOH5064 |
| C | HOH5229 |
| C | HOH5240 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 D 3601 |
| Chain | Residue |
| B | HIS116 |
| B | ASP117 |
| B | HOH3735 |
| B | HOH3800 |
| D | GLY218 |
| D | ARG219 |
| D | GLY220 |
| D | HOH3923 |
| D | HOH3941 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3602 |
| Chain | Residue |
| A | GLY218 |
| A | ARG219 |
| A | GLY220 |
| A | HOH3723 |
| A | HOH3761 |
| A | HOH3839 |
| C | HIS116 |
| C | ASP117 |
| C | HOH5022 |
| C | HOH5197 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 B 3603 |
| Chain | Residue |
| B | GLY218 |
| B | ARG219 |
| B | GLY220 |
| B | HOH3765 |
| B | HOH3771 |
| B | HOH3792 |
| D | HIS116 |
| D | ASP117 |
| D | HOH3806 |
| D | HOH3895 |
| D | HOH4030 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 H 3604 |
| Chain | Residue |
| E | HIS116 |
| E | ASP117 |
| E | HIS119 |
| E | HOH6110 |
| E | HOH6270 |
| H | GLY218 |
| H | ARG219 |
| H | GLY220 |
| H | HOH6106 |
| H | HOH6174 |
| H | HOH6365 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 G 3605 |
| Chain | Residue |
| F | HIS116 |
| F | ASP117 |
| F | HOH4712 |
| F | HOH4898 |
| F | HOH4928 |
| G | GLY218 |
| G | ARG219 |
| G | GLY220 |
| G | HOH4991 |
| G | HOH5003 |
| G | HOH5027 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 F 3606 |
| Chain | Residue |
| F | GLY218 |
| F | ARG219 |
| F | GLY220 |
| F | HOH4765 |
| F | HOH4867 |
| F | HOH4874 |
| G | HIS116 |
| G | ASP117 |
| G | HOH4913 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 E 3607 |
| Chain | Residue |
| E | GLY218 |
| E | ARG219 |
| E | GLY220 |
| E | HOH6161 |
| E | HOH6177 |
| E | HOH6202 |
| H | HIS116 |
| H | ASP117 |
| H | HOH6142 |
| H | HOH6222 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3700 |
| Chain | Residue |
| A | ARG128 |
| A | GLU215 |
| A | HOH3801 |
| F | ASP151 |
| F | GLN152 |
| F | HOH4877 |
| F | HOH4938 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 3701 |
| Chain | Residue |
| B | ARG128 |
| B | GLU215 |
| B | HOH3986 |
| B | HOH4011 |
| E | ASP151 |
| E | GLN152 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 3702 |
| Chain | Residue |
| C | ARG128 |
| C | GLN129 |
| C | THR130 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 3703 |
| Chain | Residue |
| D | GLN129 |
| D | THR130 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 3800 |
| Chain | Residue |
| D | GLN152 |
| H | ARG128 |
| H | GLU215 |
| H | HOH6192 |
| H | HOH6269 |
| D | ASP151 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 F 4700 |
| Chain | Residue |
| F | ARG128 |
| F | GLN129 |
| F | THR130 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 G 4900 |
| Chain | Residue |
| G | ARG62 |
| G | HOH5186 |
| H | ARG62 |
| H | GLN65 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 G 3704 |
| Chain | Residue |
| C | ASP151 |
| C | GLN152 |
| G | ARG128 |
| G | GLU215 |
| G | HOH5068 |
| G | HOH5204 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 5000 |
| Chain | Residue |
| C | ARG62 |
| D | ARG62 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 5001 |
| Chain | Residue |
| E | ARG62 |
| E | HOH6355 |
| F | ARG62 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 6100 |
| Chain | Residue |
| E | GLN127 |
| E | ARG128 |
| E | GLN129 |
| E | THR130 |
| E | HOH6265 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 H 6101 |
| Chain | Residue |
| H | SER12 |
| H | GLY13 |
| H | THR14 |
| H | ARG15 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| A | ARG15 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| B | ARG15 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| C | ARG15 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| D | ARG15 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| E | ARG15 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| F | ARG15 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| G | ARG15 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hv9 |
| Chain | Residue | Details |
| H | ARG15 |
