1FXX
THE STRUCTURE OF EXONUCLEASE I SUGGESTS HOW PROCESSIVITY IS ACHIEVED
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003697 | molecular_function | single-stranded DNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0004529 | molecular_function | DNA exonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006274 | biological_process | DNA replication termination |
| A | 0006281 | biological_process | DNA repair |
| A | 0006308 | biological_process | DNA catabolic process |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008310 | molecular_function | single-stranded DNA 3'-5' DNA exonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051575 | molecular_function | 5'-deoxyribose-5-phosphate lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 501 |
| Chain | Residue |
| A | ASP15 |
| A | TYR102 |
| A | ASP108 |
| A | HOH627 |
| A | HOH640 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 601 |
| Chain | Residue |
| A | ASN255 |
| A | HIS302 |
| A | ASN304 |
| A | LYS305 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 602 |
| Chain | Residue |
| A | SER233 |
| A | LYS299 |
| A | HOH687 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11101894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18219121","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18591666","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20018747","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23609540","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18219121","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Site: {"description":"Interaction with single-stranded DNA","evidences":[{"source":"PubMed","id":"23609540","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Site: {"description":"Important for interaction with ssb","evidences":[{"source":"PubMed","id":"18591666","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Site: {"description":"Interaction with single-stranded DNA","evidences":[{"source":"PubMed","id":"23609540","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HCC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for activity","evidences":[{"source":"PubMed","id":"23609540","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for interaction with ssb","evidences":[{"source":"PubMed","id":"20018747","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
