1FX7
CRYSTAL STRUCTURE OF THE IRON-DEPENDENT REGULATOR (IDER) FROM MYCOBACTERIUM TUBERCULOSIS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0019540 | biological_process | catechol-containing siderophore biosynthetic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046870 | molecular_function | cadmium ion binding |
| A | 0046914 | molecular_function | transition metal ion binding |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0050897 | molecular_function | cobalt ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0008198 | molecular_function | ferrous iron binding |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0019540 | biological_process | catechol-containing siderophore biosynthetic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046870 | molecular_function | cadmium ion binding |
| B | 0046914 | molecular_function | transition metal ion binding |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0050897 | molecular_function | cobalt ion binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0008198 | molecular_function | ferrous iron binding |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0009274 | cellular_component | peptidoglycan-based cell wall |
| C | 0016151 | molecular_function | nickel cation binding |
| C | 0019540 | biological_process | catechol-containing siderophore biosynthetic process |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| C | 0046870 | molecular_function | cadmium ion binding |
| C | 0046914 | molecular_function | transition metal ion binding |
| C | 0046983 | molecular_function | protein dimerization activity |
| C | 0050897 | molecular_function | cobalt ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0008198 | molecular_function | ferrous iron binding |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0009274 | cellular_component | peptidoglycan-based cell wall |
| D | 0016151 | molecular_function | nickel cation binding |
| D | 0019540 | biological_process | catechol-containing siderophore biosynthetic process |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| D | 0046870 | molecular_function | cadmium ion binding |
| D | 0046914 | molecular_function | transition metal ion binding |
| D | 0046983 | molecular_function | protein dimerization activity |
| D | 0050897 | molecular_function | cobalt ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1001 |
| Chain | Residue |
| A | ARG55 |
| A | ALA57 |
| A | GLY58 |
| A | HIS212 |
| A | GLU213 |
| A | HOH2074 |
| A | HOH2134 |
| A | HOH2171 |
| A | HOH2186 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1002 |
| Chain | Residue |
| B | LEU26 |
| B | ARG27 |
| B | ALA28 |
| B | ARG60 |
| B | HOH2055 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1003 |
| Chain | Residue |
| B | ARG60 |
| C | VAL23 |
| C | THR24 |
| C | ARG29 |
| C | HOH2015 |
| C | HOH2100 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1004 |
| Chain | Residue |
| A | VAL23 |
| A | THR24 |
| A | ARG29 |
| A | HOH2013 |
| A | HOH2016 |
| A | HOH2017 |
| A | HOH2018 |
| D | THR24 |
| D | ARG29 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1005 |
| Chain | Residue |
| B | VAL23 |
| B | THR24 |
| B | HOH2014 |
| B | HOH2016 |
| B | HOH2066 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1006 |
| Chain | Residue |
| A | LEU26 |
| A | ARG27 |
| A | ALA28 |
| A | ARG60 |
| A | HOH2062 |
| A | HOH2069 |
| D | ALA28 |
| D | HOH2117 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1007 |
| Chain | Residue |
| B | ARG27 |
| C | LEU26 |
| C | ARG27 |
| C | ALA28 |
| C | ARG60 |
| C | HOH2066 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1008 |
| Chain | Residue |
| A | PRO123 |
| A | THR124 |
| A | THR125 |
| A | HOH2213 |
| A | HOH2237 |
| A | HOH2252 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1009 |
| Chain | Residue |
| B | ARG84 |
| B | PRO123 |
| B | THR124 |
| B | THR125 |
| B | HOH2160 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1010 |
| Chain | Residue |
| C | PRO123 |
| C | THR124 |
| C | THR125 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1011 |
| Chain | Residue |
| B | ARG55 |
| B | THR65 |
| B | GLU66 |
| B | HOH2076 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1012 |
| Chain | Residue |
| A | ARG115 |
| D | PRO201 |
| D | GLY202 |
| D | HOH2074 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1013 |
| Chain | Residue |
| A | LYS78 |
| A | SER109 |
| A | GLU110 |
| A | HOH2026 |
| A | HOH2050 |
| A | HOH2198 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1014 |
| Chain | Residue |
| B | LYS78 |
| B | SER109 |
| B | GLU110 |
| B | HOH2042 |
| B | HOH2044 |
| B | HOH2104 |
| B | HOH2159 |
| B | HOH2215 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1015 |
| Chain | Residue |
| D | ARG55 |
| D | THR65 |
| D | GLU66 |
| D | HOH2128 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1016 |
| Chain | Residue |
| B | ARG194 |
| C | HOH2138 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1017 |
| Chain | Residue |
| A | ARG183 |
| A | THR216 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO A 2001 |
| Chain | Residue |
| A | HIS79 |
| A | GLU83 |
| A | HIS98 |
| A | GLU172 |
| A | GLN175 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO A 2002 |
| Chain | Residue |
| A | GLU105 |
| A | HIS106 |
| A | HOH2011 |
| A | MET10 |
| A | CYS102 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO B 2003 |
| Chain | Residue |
| B | HIS79 |
| B | GLU83 |
| B | HIS98 |
| B | GLU172 |
| B | GLN175 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO B 2004 |
| Chain | Residue |
| B | MET10 |
| B | CYS102 |
| B | GLU105 |
| B | HIS106 |
| B | HOH2012 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO C 2005 |
| Chain | Residue |
| C | HIS79 |
| C | GLU83 |
| C | HIS98 |
| C | GLU172 |
| C | GLN175 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO C 2006 |
| Chain | Residue |
| C | MET10 |
| C | CYS102 |
| C | GLU105 |
| C | HIS106 |
| C | HOH2013 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO D 2007 |
| Chain | Residue |
| D | HIS79 |
| D | GLU83 |
| D | HIS98 |
| D | GLU172 |
| D | GLN175 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO D 2008 |
| Chain | Residue |
| D | MET10 |
| D | CYS102 |
| D | GLU105 |
| D | HIS106 |
| D | HOH2015 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CO A 2009 |
| Chain | Residue |
| A | HIS219 |
| A | HIS223 |
| A | HOH2013 |
| A | HOH2014 |
| A | HOH2015 |
| A | HOH2016 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO B 2010 |
| Chain | Residue |
| B | HIS219 |
| B | HIS223 |
| B | HOH2014 |
| B | HOH2015 |
| B | HOH2016 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CO C 2011 |
| Chain | Residue |
| C | HIS219 |
| C | HIS223 |
| C | HOH2015 |
| C | HOH2016 |
| C | HOH2017 |
| C | HOH2018 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CO D 2012 |
| Chain | Residue |
| D | HIS219 |
| D | HIS223 |
| D | HOH2017 |
| D | HOH2018 |
| D | HOH2019 |
| D | HOH2020 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO D 2013 |
| Chain | Residue |
| B | HIS212 |
| C | HIS212 |
| D | HIS212 |
| D | HOH2021 |
| D | HOH2022 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLPHEMAHAV |
| Chain | Residue | Details |
| A | THR216-VAL225 |
